Arthropathy of genetic hemochromatosis : A major and distinctive manifestation of the disease

Genetic hemochromatosis is not a rare disease and represents a frequently underestimated cause of arthropathy. Joint involvement is one of the most frequent manifestations of the disease and presents typical clinical and radiological features that strongly suggest the diagnosis. Joint complaints are...

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Bibliographic Details
Published in:	Clinical and experimental rheumatology Vol. 19; no. 1; pp. 98 - 102
Main Authors:	INES, L. S, DA SILVA, J. A. P, MALCATA, A. B, PORTO, A. L
Format:	Journal Article
Language:	English
Published:	Pisa Clinical and Experimental Rheumatology 2001
Subjects:	Arthropathy, Neurogenic - etiology Arthropathy, Neurogenic - genetics Biological and medical sciences Hemochromatosis - complications Hemochromatosis - epidemiology Hemochromatosis - genetics Humans Medical sciences Metabolic diseases Metals (hemochromatosis...) Other metabolic disorders Human Hemochromatosis Radiodiagnosis Pathogenesis Diseases of the osteoarticular system Clinical form Metabolic diseases Iron Enzymopathy Epidemiology Genetic disease Radiography Symptomatology Treatment Arthropathy Complication Genetics Diagnosis Public health
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Summary:	Genetic hemochromatosis is not a rare disease and represents a frequently underestimated cause of arthropathy. Joint involvement is one of the most frequent manifestations of the disease and presents typical clinical and radiological features that strongly suggest the diagnosis. Joint complaints are often the first clinical manifestation of GH. Their identification may be crucial to establish the diagnosis in the pre-cirrhotic phase and to institute appropriate therapy to prevent organ damage and associated mortality. Recent identification of the genetic defect responsible for the disease is leading to new insights into the pathogenesis of GH and the associated arthropathy.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0392-856X 1593-098X