Search Results - "MALBERG, Jessica E"

Cell Proliferation in Adult Hippocampus is Decreased by Inescapable Stress: Reversal by Fluoxetine Treatment by MALBERG, Jessica E, DUMAN, Ronald S

“…Adult hippocampal neurogenesis has been demonstrated in several species and is regulated by both environmental and pharmacological stimuli. The present study…”
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Central administration of IGF-I and BDNF leads to long-lasting antidepressant-like effects by Hoshaw, Brian A., Malberg, Jessica E., Lucki, Irwin

“…Drug development research has identified neurotrophic factors as a downstream target of chronic antidepressant treatments. In order to study their…”
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Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments by Balu, Darrick T, Hoshaw, Brian A, Malberg, Jessica E, Rosenzweig-Lipson, Sharon, Schechter, Lee E, Lucki, Irwin

“…Abstract Antidepressant treatments have been proposed to produce their therapeutic effects, in part, through increasing neurotrophin levels in the brain. The…”
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Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus by Malberg, Jessica E, Eisch, Amelia J, Nestler, Eric J, Duman, Ronald S

“…Recent studies suggest that stress-induced atrophy and loss of hippocampal neurons may contribute to the pathophysiology of depression. The aim of this study…”
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Antidepressant action: to the nucleus and beyond by Malberg, Jessica E., Blendy, Julie A.

“…After decades of effort, the field of depression research is far from understanding how antidepressant drugs mediate their clinical effects. The time lag of…”
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Anxiolytic-like activity of oxytocin in male mice : behavioral and autonomic evidence, therapeutic implications by RING, Robert H, MALBERG, Jessica E, POTESTIO, Lisa, JULIA PING, BOIKESS, Steve, BIN LUO, SCHECHTER, Lee E, RIZZO, Stacey, RAHMAN, Zia, ROSENZWEIG-LIPSON, Sharon

“…Oxytocin (OT) acts as a neuromodulator/neurotransmitter within the central nervous system (CNS) and regulates a diverse range of CNS functions. Notably,…”
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Increasing the Levels of Insulin-Like Growth Factor-I by an IGF Binding Protein Inhibitor Produces Anxiolytic and Antidepressant-Like Effects by Malberg, Jessica E, Platt, Brian, Rizzo, Stacey J Sukoff, Ring, Robert H, Lucki, Irwin, Schechter, Lee E, Rosenzweig-Lipson, Sharon

“…The present studies were conducted to determine if increasing central levels of the neurotrophic factor insulin-like growth factor-1 (IGF-I) either directly or…”
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cAMP Response Element-Binding Protein Deficiency Allows for Increased Neurogenesis and a Rapid Onset of Antidepressant Response by Gur, Tamar L, Conti, Alana C, Holden, Jessica, Bechtholt, Anita J, Hill, Tiffany E, Lucki, Irwin, Malberg, Jessica E, Blendy, Julie A

“…cAMP response element-binding protein (CREB) has been implicated in the molecular and cellular mechanisms of chronic antidepressant (AD) treatment, although…”
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Small Changes in Ambient Temperature Cause Large Changes in 3,4-Methylenedioxymethamphetamine (MDMA)-Induced Serotonin Neurotoxicity and Core Body Temperature in the Rat by Malberg, Jessica E, Seiden, Lewis S

“…The amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA) is a drug of abuse and has been shown to be neurotoxic to 5-HT terminals in many species…”
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Adult Neurogenesis and Antidepressant Treatment: The Surprise Finding by Ron Duman and the Field 20 Years Later by Malberg, Jessica E., Hen, René, Madsen, Torsten M.

“…Of Duman’s many influential findings, the finding that long-term treatment with antidepressant drugs produces an increase in neurogenesis in the subgranular…”
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Implications of adult hippocampal neurogenesis in antidepressant action by MALBERG, Jessica E

“…In the dentate gyrus of the hippocampus, cell birth and maturation into neurons, or neurogenesis, occur throughout the lifetime of animals and humans. Multiple…”
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Pharmacology of neuropeptide S in mice: therapeutic relevance to anxiety disorders by Leonard, Sarah K., Dwyer, Jason M., Sukoff Rizzo, Stacey J., Platt, Brian, Logue, Sheree F., Neal, Sarah J., Malberg, Jessica E., Beyer, Chad E., Schechter, Lee E., Rosenzweig-Lipson, Sharon, Ring, Robert H.

“…Rationale Neuropeptide S (NPS) and its receptor (NPSR) comprise a recently deorphaned G protein-coupled receptor system. Recent reports implicate NPS in the…”
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Differentiating antidepressants of the future: efficacy and safety by Rosenzweig-Lipson, Sharon, Beyer, Chad E, Hughes, Zoë A, Khawaja, Xavier, Rajarao, Somana J, Malberg, Jessica E, Rahman, Zia, Ring, Robert H, Schechter, Lee E

“…There have been significant advances in the treatment of depression since the serendipitous discovery that modulating monoaminergic neurotransmission may be a…”
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Regulation of Neurogenesis in Adult Mouse Hippocampus by cAMP and the cAMP Response Element-Binding Protein by Nakagawa, Shin, Kim, Ji-Eun, Lee, Rena, Malberg, Jessica E, Chen, Jingshan, Steffen, Cathy, Zhang, Ya-Jun, Nestler, Eric J, Duman, Ronald S

“…The cAMP cascade, including the cAMP response element-binding protein (CREB), is known to play an important role in neuronal survival and plasticity. Here the…”
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Innovative Approaches for the Development of Antidepressant Drugs: Current and Future Strategies by Schechter, Lee E., Ring, Robert H., Beyer, Chad E., Hughes, Zoë A., Khawaja, Xavier, Malberg, Jessica E., Rosenzweig-Lipson, Sharon

“…Depression is a highly debilitating disorder that has been estimated to affect up to 21% of the world population. Despite the advances in the treatment of…”
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Increasing hippocampal neurogenesis: a novel mechanism for antidepressant drugs by Malberg, Jessica E, Schechter, Lee E

“…The birth of new neurons, or neurogenesis, in the hippocampal formation has been demonstrated throughout the lifetime of multiple species including humans. A…”
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Antidepressant-like effects of the novel, selective, 5-HT2C receptor agonist WAY-163909 in rodents by ROSENZWEIG-LIPSON, Sharon, SABB, Annmarie, DUNLOP, John, BARRETT, James E, MARQUIS, Karen L, STACK, Gary, MITCHELL, Paul, LUCKI, Irwin, MALBERG, Jessica E, GRAUER, Steve, BRENNAN, Julie, CRYAN, John F, SUKOFF RIZZO, Stacey J

“…Activation of one or more of the serotonin (5-HT) receptors may play a role in mediating the antidepressant effects of SSRIs. The present studies were…”
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VGF, a new player in antidepressant action? by Malberg, Jessica E, Monteggia, Lisa M

“…Recent studies have identified adaptations of intracellular signaling pathways and target genes that could contribute or modulate the action of antidepressant…”
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Selective 5-Hydroxytryptamine 2C Receptor Agonists Derived from the Lead Compound Tranylcypromine: Identification of Drugs with Antidepressant-Like Action by Cho, Sung Jin, Jensen, Niels H, Kurome, Toru, Kadari, Sudhakar, Manzano, Michael L, Malberg, Jessica E, Caldarone, Barbara, Roth, Bryan L, Kozikowski, Alan P

“…We report here the design, synthesis, and pharmacological properties of a series of compounds related to tranylcypromine (9), which itself was discovered as a…”
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5-HT1A receptor antagonism reverses and prevents fluoxetine-induced sexual dysfunction in rats by Sukoff Rizzo, Stacey J., Pulicicchio, Claudine, Malberg, Jessica E., Andree, Terrance H., Stack, Gary P., Hughes, Zoë A., Schechter, Lee E., Rosenzweig-Lipson, Sharon

“…Sexual dysfunction associated with antidepressant treatment continues to be a major compliance issue for antidepressant therapies. 5-HT1A antagonists have been…”
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