Search Results - "MALAFA, Mokenge P"

Stereotactic Body Radiation Therapy for Locally Advanced and Borderline Resectable Pancreatic Cancer Is Effective and Well Tolerated by Chuong, Michael D., MD, Springett, Gregory M., MD, PhD, Freilich, Jessica M., MD, Park, Catherine K., MD, MPH, Weber, Jill M., MPH, Mellon, Eric A., MD, PhD, Hodul, Pamela J., MD, Malafa, Mokenge P., MD, Meredith, Kenneth L., MD, Hoffe, Sarah E., MD, Shridhar, Ravi, MD, PhD

“…Purpose Stereotactic body radiation therapy (SBRT) provides high rates of local control (LC) and margin-negative (R0) resections for locally advanced…”
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Long-term outcomes of induction chemotherapy and neoadjuvant stereotactic body radiotherapy for borderline resectable and locally advanced pancreatic adenocarcinoma by Mellon, Eric A, Hoffe, Sarah E, Springett, Gregory M, Frakes, Jessica M, Strom, Tobin J, Hodul, Pamela J, Malafa, Mokenge P, Chuong, Michael D, Shridhar, Ravi

“…Limited data are available to guide neoadjuvant treatment of borderline resectable (BRPC) and locally advanced (LAPC) pancreatic cancer. We updated our…”
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Elevating pancreatic cystic lesion stratification: Current and future pancreatic cancer biomarker(s) by Carmicheal, Joseph, Patel, Asish, Dalal, Vipin, Atri, Pranita, Dhaliwal, Amaninder S., Wittel, Uwe A., Malafa, Mokenge P., Talmon, Geoffrey, Swanson, Benjamin J., Singh, Shailender, Jain, Maneesh, Kaur, Sukhwinder, Batra, Surinder K.

“…Pancreatic ductal adenocarcinoma (PDAC) is an incredibly deadly disease with a 5-year survival rate of 9%. The presence of pancreatic cystic lesions (PCLs)…”
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Farnesyl dimethyl chromanol targets colon cancer stem cells and prevents colorectal cancer metastasis by Husain, Kazim, Coppola, Domenico, Yang, Chung S., Malafa, Mokenge P.

“…The activation and growth of tumour-initiating cells with stem-like properties in distant organs characterize colorectal cancer (CRC) growth and metastasis…”
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Neutrophil to lymphocyte ratio, not platelet to lymphocyte or lymphocyte to monocyte ratio, is predictive of patient survival after resection of early-stage pancreatic ductal adenocarcinoma by Pointer, Jr, David T, Roife, David, Powers, Benjamin D, Murimwa, Gilbert, Elessawy, Sameh, Thompson, Zachary J, Schell, Michael J, Hodul, Pamela J, Pimiento, Jose M, Fleming, Jason B, Malafa, Mokenge P

“…NLR, PLR, and LMR have been associated with pancreatic ductal adenocarcinoma (PDAC) survival. Prognostic value and optimal cutpoints were evaluated to identify…”
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Effect of Metformin Use on Survival in Resectable Pancreatic Cancer: A Single-Institution Experience and Review of the Literature by Ambe, Chenwi M, Mahipal, Amit, Fulp, Jimmy, Chen, Lu, Malafa, Mokenge P

“…Observational studies have demonstrated that metformin use in diabetic patients is associated with reduced cancer incidence and mortality. Here, we aimed to…”
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Case Report of Isolated Gastric Metastasis of Pancreatic Cancer From a Diagnostic Biopsy: Management of a Rare Oncologic Entity by Rothermel, Luke D., Strosberg, Carolina, Centeno, Barbara A., Malafa, Mokenge P.

“…Pancreatic ductal adenocarcinoma behaves aggressively, with surgically resectable disease having the best chance of long-term survival. Recurrence after…”
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Linc-ing Circulating Long Non-coding RNAs to the Diagnosis and Malignant Prediction of Intraductal Papillary Mucinous Neoplasms of the Pancreas by Permuth, Jennifer B., Chen, Dung-Tsa, Yoder, Sean J., Li, Jiannong, Smith, Andrew T., Choi, Jung W., Kim, Jongphil, Balagurunathan, Yoganand, Jiang, Kun, Coppola, Domenico, Centeno, Barbara A., Klapman, Jason, Hodul, Pam, Karreth, Florian A., Trevino, Jose G., Merchant, Nipun, Magliocco, Anthony, Malafa, Mokenge P., Gillies, Robert

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease that lacks effective biomarkers for early detection. We hypothesized that circulating long…”
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Increased neutrophil-to-lymphocyte ratio after neoadjuvant therapy is associated with worse survival after resection of borderline resectable pancreatic ductal adenocarcinoma by Glazer, Evan S., MD, PhD, Rashid, Omar M., MD, JD, Pimiento, Jose M., MD, Hodul, Pamela J., MD, FACS, Malafa, Mokenge P., MD, FACS

“…Background The neutrophil-to-lymphocyte ratio (neutrophil count divided by lymphocyte count) is a marker of inflammation associated with poor cancer outcomes…”
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Early detection of pancreatic cancer: why, who, and how to screen by Klapman, Jason, Malafa, Mokenge P

“…Pancreatic cancer represents the fourth-leading cause of cancer death in the United States, with a dismal 5-year survival rate of less than 5%. Despite…”
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Vitamins in Pancreatic Cancer: A Review of Underlying Mechanisms and Future Applications by Davis-Yadley, Ashley H, Malafa, Mokenge P

“…Although there is increasing evidence that vitamins influence pancreatic adenocarcinoma biology and carcinogenesis, a comprehensive review is lacking. In this…”
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Systematic Review and Case Series Report of Acinar Cell Carcinoma of the Pancreas by Glazer, Evan S, Neill, Kevin G, Frakes, Jessica M, Coppola, Domenico, Hodul, Pamela J, Hoffe, Sara E, Pimiento, Jose M, Springett, Gregory M, Malafa, Mokenge P

“…Acinar cell carcinoma of the pancreas is a rare malignancy representing less than 1% of all pancreatic malignancies. We report on a case series of 21 patients…”
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A Phase I Safety, Pharmacokinetic, and Pharmacodynamic Presurgical Trial of Vitamin E δ-tocotrienol in Patients with Pancreatic Ductal Neoplasia by Springett, Gregory M., Husain, Kazim, Neuger, Anthony, Centeno, Barbara, Chen, Dung-Tsa, Hutchinson, Tai Z., Lush, Richard M., Sebti, Saïd, Malafa, Mokenge P.

“…Vitamin E δ-tocotrienol (VEDT), a natural vitamin E from plants, has shown anti-neoplastic and chemoprevention activity in preclinical models of pancreatic…”
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Outcomes of a Clinical Pathway for Borderline Resectable Pancreatic Cancer by Rashid, Omar M., Pimiento, Jose M., Gamenthaler, Andrew W., Nguyen, Phuong, Ha, Tin T., Hutchinson, Tai, Springett, Gregory, Hoffe, Sarah, Shridhar, Ravi, Hodul, Pamela J., Johnson, Brad L., Illig, Karl, Armstrong, Paul A., Centeno, Barbara A., Fulp, William J., Chen, Dung-Tsa, Malafa, Mokenge P.

“…Background Without prospective data establishing a consensus multimodality approach to borderline resectable pancreatic adenocarcinoma, institutional treatment…”
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Effects of a Brief Multimedia Psychoeducational Intervention on the Attitudes and Interest of Patients With Cancer Regarding Clinical Trial Participation: A Multicenter Randomized Controlled Trial by JACOBSEN, Paul B, WELLS, Kristen J, MARKHAM, Merry-Jennifer, SCHREIBER, Fred J, CARTWRIGHT, Thomas H, BURKE, James M, SIEGEL, Robert D, MALAFA, Mokenge P, SULLIVAN, Daniel, MEADE, Cathy D, QUINN, Gwendolyn P, LEE, Ji-Hyun, FULP, William J, GRAY, Jhanelle E, BAZ, Rachid C, SPRINGETT, Gregory M, LEVINE, Richard M

“…The negative attitudes of patients with cancer regarding clinical trials are an important contributor to low participation rates. This study evaluated whether…”
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Vitamin E δ-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIPs by Francois, Rony A., Zhang, Anying, Husain, Kazim, Wang, Chen, Hutchinson, Sean, Kongnyuy, Michael, Batra, Surinder K., Coppola, Domenico, Sebti, Said M., Malafa, Mokenge P.

“…BACKGROUNDVitamin E δ-tocotrienol (VEDT), a vitamin E compound isolated from sources such as palm fruit and annatto beans, has been reported to have cancer…”
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Vitamin E δ-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism by Hodul, Pamela J, Dong, Yanbin, Husain, Kazim, Pimiento, Jose M, Chen, Jiandong, Zhang, Anying, Francois, Rony, Pledger, Warren J, Coppola, Domenico, Sebti, Said M, Chen, Dung-Tsa, Malafa, Mokenge P

“…Vitamin E δ-tocotrienol has been shown to have antitumor activity, but the precise molecular mechanism by which it inhibits the proliferation of cancer cells…”
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Identification of nonalcoholic fatty liver disease following pancreatectomy for noninvasive intraductal papillary mucinous neoplasm by Luu, Carrie, Thapa, Ram, Rose, Trevor, Woo, Katherine, Jeong, Daniel, Thomas, Kerry, Chen, Dung-Tsa, Friedman, Mark, Malafa, Mokenge P., Hodul, Pamela J.

“…Nonalcoholic fatty liver disease (NAFLD) following pancreatectomy is a potential cause of long term morbidity in patients undergoing pancreatic resection with…”
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Metabolic Activity by 18F-FDG-PET/CT Is Prognostic for Stage I and II Pancreatic Cancer by Pimiento, Jose M, Davis-Yadley, Ashley H, Kim, Richard D, Chen, Dung-Tsa, Eikman, Edward A, Berman, Claudia G, Malafa, Mokenge P

“…PURPOSEMetabolic activity, as defined by F-FDG uptake on PET, is a prognostic marker for multiple malignancies; however, no study has examined the prognostic…”
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Targeting the IκB Kinase Enhancer and Its Feedback Circuit in Pancreatic Cancer by Challa, Sridevi, Husain, Kazim, Kim, Richard, Coppola, Domenico, Batra, Surinder K., Cheng, Jin Q., Malafa, Mokenge P.

“…Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with an overall median 5-year survival rate of 8%. This poor prognosis is because of the…”
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