Search Results - "MAKAROVA, Alena V"

Multifaceted Nature of DNA Polymerase θ by Kruchinin, Alexander A, Makarova, Alena V

“…DNA polymerase θ belongs to the A family of DNA polymerases and plays a key role in DNA repair and damage tolerance, including double-strand break repair and…”
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Regulation of Human DNA Primase-Polymerase PrimPol by Boldinova, Elizaveta O., Makarova, Alena V.

“…Transmission of genetic information depends on successful completion of DNA replication. Genomic DNA is subjected to damage on a daily basis. DNA lesions…”
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DNA synthesis across DNA hairpins by human PrimPol by Boldinova, Elizaveta O., Baranovskiy, Andrey G., Esyunina, Daria, Tahirov, Tahir H., Makarova, Alena V.

“…PrimPol is a human DNA primase involved in DNA damage tolerance pathways by restarting DNA replication downstream of DNA lesions and non-canonical DNA…”
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The role of catalytic and regulatory domains of human PrimPol in DNA binding and synthesis by Boldinova, Elizaveta O, Baranovskiy, Andrey G, Gagarinskaya, Diana I, Manukyan, Anna A, Makarova, Alena V, Tahirov, Tahir H

“…Abstract Human PrimPol possesses DNA primase and DNA polymerase activities and restarts stalled replication forks protecting cells against DNA damage in nuclei…”
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Methylation and hydroxymethylation of cytosine alter activity and fidelity of translesion DNA polymerases by Shilkin, Evgeniy S., Petrova, Daria V., Novikova, Anna A., Boldinova, Elizaveta O., Zharkov, Dmitry O., Makarova, Alena V.

“…Epigenetic cytosine methylation covers most of genomic CpG dinucleotides in human cells. In addition to common deamination-mediated mutagenesis at CpG sites,…”
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The Catalytic Activity of Human REV1 on Undamaged and Damaged DNA by Stolyarenko, Anastasia D, Novikova, Anna A, Shilkin, Evgeniy S, Poltorachenko, Valentin A, Makarova, Alena V

“…Eukaryotic REV1 serves as a scaffold protein for the coordination of DNA polymerases during DNA translesion synthesis. Besides this structural role, REV1 is a…”
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Translesion activity of PrimPol on DNA with cisplatin and DNA–protein cross-links by Boldinova, Elizaveta O., Yudkina, Anna V., Shilkin, Evgeniy S., Gagarinskaya, Diana I., Baranovskiy, Andrey G., Tahirov, Tahir H., Zharkov, Dmitry O., Makarova, Alena V.

“…Human PrimPol belongs to the archaeo-eukaryotic primase superfamily of primases and is involved in de novo DNA synthesis downstream of blocking DNA lesions and…”
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8-Oxoadenine: A «New» Player of the Oxidative Stress in Mammals? by Kruchinin, Alexander A, Kamzeeva, Polina N, Zharkov, Dmitry O, Aralov, Andrey V, Makarova, Alena V

“…Numerous studies have shown that oxidative modifications of guanine (7,8-dihydro-8-oxoguanine, 8-oxoG) can affect cellular functions. 7,8-Dihydro-8-oxoadenine…”
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Bypass of Abasic Site-Peptide Cross-Links by Human Repair and Translesion DNA Polymerases by Yudkina, Anna V, Barmatov, Alexander E, Bulgakov, Nikita A, Boldinova, Elizaveta O, Shilkin, Evgeniy S, Makarova, Alena V, Zharkov, Dmitry O

“…DNA-protein cross-links remain the least-studied type of DNA damage. Recently, their repair was shown to involve proteolysis; however, the fate of the peptide…”
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Isoforms of Base Excision Repair Enzymes Produced by Alternative Splicing by Boldinova, Elizaveta O, Khairullin, Rafil F, Makarova, Alena V, Zharkov, Dmitry O

“…Transcripts of many enzymes involved in base excision repair (BER) undergo extensive alternative splicing, but functions of the corresponding alternative…”
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Optimization of the expression, purification and polymerase activity reaction conditions of recombinant human PrimPol by Boldinova, Elizaveta O, Stojkovič, Gorazd, Khairullin, Rafil, Wanrooij, Sjoerd, Makarova, Alena V

“…Human PrimPol is a DNA primase/polymerase involved in DNA damage tolerance and prevents nuclear genome instability. PrimPol is also localized to the…”
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Base Excision DNA Repair Deficient Cells: From Disease Models to Genotoxicity Sensors by Kim, Daria V, Makarova, Alena V, Miftakhova, Regina R, Zharkov, Dmitry O

“…Base excision DNA repair (BER) is a vitally important pathway that protects the cell genome from many kinds of DNA damage, including oxidation, deamination,…”
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Strand Displacement Activity of PrimPol by Boldinova, Elizaveta O, Belousova, Ekaterina A, Gagarinskaya, Diana I, Maltseva, Ekaterina A, Khodyreva, Svetlana N, Lavrik, Olga I, Makarova, Alena V

“…Human PrimPol is a unique enzyme possessing DNA/RNA primase and DNA polymerase activities. In this work, we demonstrated that PrimPol efficiently fills a 5-nt…”
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DNA Damage Tolerance by Eukaryotic DNA Polymerase and Primase PrimPol by Boldinova, Elizaveta O, Wanrooij, Paulina H, Shilkin, Evgeniy S, Wanrooij, Sjoerd, Makarova, Alena V

“…PrimPol is a human deoxyribonucleic acid (DNA) polymerase that also possesses primase activity and is involved in DNA damage tolerance, the prevention of…”
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Reading and Misreading 8-oxoguanine, a Paradigmatic Ambiguous Nucleobase by Yudkina, Anna, Shilkin, Evgeniy, Endutkin, Anton, Makarova, Alena, Zharkov, Dmitry

“…7,8-Dihydro-8-oxoguanine (oxoG) is the most abundant oxidative DNA lesion with dual coding properties. It forms both Watson–Crick (anti)oxoG:(anti)C and…”
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In a search of a protective titer: Do we or do we not need to know? by Baranova, Ancha, Chandhoke, Vikas, Makarova, Alena V., Veytsman, Boris

“…The level of postvaccine protection depends on two factors: antibodies and T‐cell responses. While the first one is relatively easily measured, the measuring…”
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Eukaryotic DNA polymerase ζ by Makarova, Alena V., Burgers, Peter M.

“…This review focuses on eukaryotic DNA polymerase ζ (Pol ζ), the enzyme responsible for the bulk of mutagenesis in eukaryotic cells in response to DNA damage…”
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Inaccurate DNA synthesis in cell extracts of yeast producing active human DNA polymerase iota by Makarova, Alena V, Grabow, Corinn, Gening, Leonid V, Tarantul, Vyacheslav Z, Tahirov, Tahir H, Bessho, Tadayoshi, Pavlov, Youri I

“…Mammalian Pol ι has an unusual combination of properties: it is stimulated by Mn(2+) ions, can bypass some DNA lesions and misincorporates "G" opposite…”
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A four-subunit DNA polymerase ζ complex containing Pol δ accessory subunits is essential for PCNA-mediated mutagenesis by Makarova, Alena V, Stodola, Joseph L, Burgers, Peter M

“…DNA polymerase ζ (Pol ζ) plays a key role in DNA translesion synthesis (TLS) and mutagenesis in eukaryotes. Previously, a two-subunit Rev3-Rev7 complex had…”
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Oxidative DNA damage stalls the human mitochondrial replisome by Stojkovič, Gorazd, Makarova, Alena V., Wanrooij, Paulina H., Forslund, Josefin, Burgers, Peter M., Wanrooij, Sjoerd

“…Oxidative stress is capable of causing damage to various cellular constituents, including DNA. There is however limited knowledge on how oxidative stress…”
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