Search Results - "MAK, I. T"

Role of free radicals and substance P in magnesium deficiency by WEGLICKI, W. B, MAK, I. T, KRAMER, J. H, DICKENS, B. F, CASSIDY, M. M, STAFFORD, R. E, PHILLIPS, T. M

Get full text

Magnesium deficiency in vitro enhances free radical-induced intracellular oxidation and cytotoxicity in endothelial cells by Dickens, B.F., Weglicki, W.B., Li, Y.-S., Mak, I.T.

“…The effect of magnesium (Mg)-deficient culture on endothelial cell susceptibility to oxidative stress was examined. Bovine endothelial cells were cultured in…”
Get full text

Comparative Antioxidant Activities of Propranolol, Nifedipine, Verapamil, and Diltiazem Against Sarcolemmal Membrane Lipid Peroxidation by Mak, I Tong, Weglicki, William B

“…The antiperoxidative activities of nifedipine, verapamil, and diltiazem were compared with that of propranolol by using an in vitro model of sarcolemmal…”
Get full text

Enhanced NO production during Mg deficiency and its role in mediating red blood cell glutathione loss by Mak, I T, Komarov, A M, Wagner, T L, Stafford, R E, Dickens, B F, Weglicki, W B

“…The effect of dietary Mg deficiency on nitric oxide (NO) production and its role in mediating oxidative depletion of red blood cell (RBC) glutathione in rats…”
Get full text

Antioxidant Effects of Calcium Channel Blockers Against Free Radical Injury in Endothelial Cells: Correlation of Protection With Preservation of Glutathione Levels by Mak, I Tong, Boehme, Patricia, Weglicki, William B

“…The effects of four calcium channel blockers (nicardipine, nifedipine, verapamil, and diltiazem) on free radical injury in cultured endothelial cells were…”
Get full text

Protection by β-Blocking Agents Against Free Radical-Mediated Sarcolemmal Lipid Peroxidation by Mak, Tong I, Weglicki, William B

“…The effects of β-blocking and class I antiarrhythmic agents on free radical-mediated sarcolemmal lipid peroxidation were examined. Highly purified canine…”
Get full text

Erythrocytes from magnesium-deficient hamsters display an enhanced susceptibility to oxidative stress by Freedman, A M, Mak, I T, Stafford, R E, Dickens, B F, Cassidy, M M, Muesing, R A, Weglicki, W B

“…Previous studies in our laboratory have indicated a role for free radical participation in magnesium deficiency cardiomyopathy. We have demonstrated the…”
Get full text

Loss of red blood cell glutathione during Mg deficiency: prevention by vitamin E, D-propranolol, and chloroquine by Mak, I.T. (George Washington University Medical Center, DC.), Stafford, R, Weglicki, W.B

“…Mg-deficiency results in loss of red blood cell glutathione and was thought to be due to decreased Mg-dependent synthesis. The effects of vitamin E,…”
Get full text

Mechanisms of cardiovascular drugs as antioxidants by Weglicki, W B, Mak, I T, Simìc, M G

Get more information

Protective mechanisms of Mg-gluconate against oxidative endothelial cytotoxicity by Mak, I T, Komarov, A M, Kramer, J H, Weglicki, W B

“…The potential anti-radical properties and cytoprotective effects of Mg-gluconate were studied. When microsomal membranes were peroxidized by a *O2- driven,…”
Get more information

A widely tunable dual-wavelength CW Ti:sapphire laser with collinear output by Luo, C W, Yang, Y Q, Mak, I T, Chang, Y H, Wu, K H, Kobayashi, T

“…We report a collinear output and tunable dual-wavelength CW Ti:sapphire laser with a simple cavity configuration. The wavelength splitting range is easily…”
Get full text

Protective effects of calcium channel blockers against free radical-impaired endothelial cell proliferation by Mak, I.Tong, Boehme, Patricia, Weglicki, William B.

“…We have shown previously that the lipophilic calcium channel blockers exhibit membrane antioxidant activity. In the present study, when attached bovine aortic…”
Get full text

Neurogenic peptides and the cardiomyopathy of magnesium-deficiency: effects of substance P-receptor inhibition by Weglicki, W.B, Mak, I.T, Stafford, R.E, Dickens, B.F, Cassidy, M.M, Phillips, T.M

“…Dietary deficiency of magnesium (Mg) in rodents results in cardiomyopathic lesion formation. In our rat model, these lesions develop after 3 weeks on the…”
Get full text

Differential Sensitivity of Canine Cardiac Sarcolemmal and Microsomal Enzymes to Inhibition by Free Radical-Induced Lipid Peroxidation by Kramer, Jay H, Mak, I Tong, Weglicki, William B

“…Sarcolemmal and microsomal membranes prepared from adult canine cardiac my-ocytes (sarcolemmal Na,K-ATPase = 71.8 /imol/mg per hr and microsomal…”
Get full text

Inhibition of sarcolemmal carbon-centered free radical formation by propranolol by TONG MAK, I, ARROYO, C. M, WEGLICKI, W. B

“…The mechanism of propranolol-inhibited sarcolemmal membrane lipid peroxidation was investigated by electron spin resonance spin-trapping technique using…”
Get full text

Characterization of iron-mediated peroxidative injury in isolated hepatic lysosomes by MAK, I. T, WEGLICKI, W. B

“…Peroxidative degradation of the lysosomal membrane and the resultant release of hydrolytic enzymes may be responsible for hepatocellular injury in iron…”
Get full text

Inhibition of neutral endopeptidase potentiates neutrophil activation during Mg-deficiency in the rat by Mak, I. T., Kramer, J. H., Chmielinska, J. J., Khalid, M. H., Landgraf, K. M., Weglicki, W. B.

“… Neutral endopeptidase (NEP), which degrades substance P (SP), may regulate neutrophil activation during Mg-deficiency (MgD). Male Sprague-Dawley rats (180g)…”
Get full text

Reactions of captopril and epicaptopril with transition metal ions and hydroxyl radicals: an EPR spectroscopy study by Misík, V, Mak, I T, Stafford, R E, Weglicki, W B

“…In the present study, using the technique of EPR spin trapping with DMPO a spin trap, we demonstrated formation of thiyl radicals from thiol-containing…”
Get more information

Temporal relationship of free radical-induced lipid peroxidation and loss of latent enzyme activity in highly enriched hepatic lysosomes by Mak, I T, Misra, H P, Weglicki, W B

“…Loss of latency due to membrane lipid peroxidation induced in vitro was studied in highly purified rat liver lysosomes. Enriched fractions of lysosomes were…”
Get full text

Antioxidant properties of calcium antagonists related to membrane biophysical interactions by Mason, R.Preston, Mak, I.Tong, Trumbore, Mark W., Mason, Pamela E.

“…The antioxidant activities of representative calcium antagonists, including amlodipine, verapamil, and diltiazem, were measured in hepatic microsomal membranes…”
Get full text