Search Results - "MAJUMDER, Pradip K"

Intercellular nanotubes mediate mitochondrial trafficking between cancer and immune cells by Saha, Tanmoy, Dash, Chinmayee, Jayabalan, Ruparoshni, Khiste, Sachin, Kulkarni, Arpita, Kurmi, Kiran, Mondal, Jayanta, Majumder, Pradip K., Bardia, Aditya, Jang, Hae Lin, Sengupta, Shiladitya

“…Cancer progresses by evading the immune system. Elucidating diverse immune evasion strategies is a critical step in the search for next-generation…”
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Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition by Goldman, Aaron, Majumder, Biswanath, Dhawan, Andrew, Ravi, Sudharshan, Goldman, David, Kohandel, Mohammad, Majumder, Pradip K., Sengupta, Shiladitya

“…Understanding the emerging models of adaptive resistance is key to overcoming cancer chemotherapy failure. Using human breast cancer explants, in vitro cell…”
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Kruppel-Like Factor 2 (KLF2) Regulates Proinflammatory Activation of Monocytes by Das, Hiranmoy, Kumar, Ajay, Lin, Zhiyong, Patino, Willmar D., Hwang, Paul M., Feinberg, Mark W., Majumder, Pradip K., Jain, Mukesh K.

“…The mechanisms regulating activation of monocytes remain incompletely understood. Herein we provide evidence that Kruppel-like factor 2 (KLF2) inhibits…”
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Prostate Intraepithelial Neoplasia Induced by Prostate Restricted Akt Activation: The MPAKT Model by Majumder, Pradip K., Yeh, George, Daniel J., Febbo, Phillip G., Kum, Jennifer, Xue, Qi, Bikoff, Rachel, Ma, Hongfeng, Kantoff, Philip W., Golub, Todd R., Loda, Massimo, Sellers, William R.

“…To determine whether Akt activation was sufficient for the transformation of normal prostate epithelial cells, murine prostate restricted Akt kinase activity…”
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AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity by Chandarlapaty, Sarat, Sawai, Ayana, Scaltriti, Maurizio, Rodrik-Outmezguine, Vanessa, Grbovic-Huezo, Olivera, Serra, Violeta, Majumder, Pradip K., Baselga, Jose, Rosen, Neal

“…Activation of the PI3K-AKT pathway in tumors is modulated by negative feedback, including mTORC1-mediated inhibition of upstream signaling. We now show that…”
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Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells by BERGER, Raanan, FEBBO, Phillip G, GOLUB, Todd R, HAHN, William C, MAJUMDER, Pradip K, ZHAO, Jean J, MUKHERJEE, Shayan, SIGNORETTI, Sabina, CAMPBELL, K. Thirza, SELLERS, William R, ROBERTS, Thomas M, LODA, Massimo

“…Androgen ablation is the primary treatment modality for patients with metastatic prostate cancer; however, the role of androgen receptor signaling in prostate…”
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MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo by Hirai, Hiroshi, Sootome, Hiroshi, Nakatsuru, Yoko, Miyama, Katsuyoshi, Taguchi, Shunsuke, Tsujioka, Kyoko, Ueno, Yoko, Hatch, Harold, Majumder, Pradip K, Pan, Bo-Sheng, Kotani, Hidehito

“…The serine/threonine kinase Akt lies at a critical signaling node downstream of phosphatidylinositol-3-kinase and is important in promoting cell survival and…”
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Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity by Majumder, Biswanath, Baraneedharan, Ulaganathan, Thiyagarajan, Saravanan, Radhakrishnan, Padhma, Narasimhan, Harikrishna, Dhandapani, Muthu, Brijwani, Nilesh, Pinto, Dency D., Prasath, Arun, Shanthappa, Basavaraja U., Thayakumar, Allen, Surendran, Rajagopalan, Babu, Govind K., Shenoy, Ashok M., Kuriakose, Moni A., Bergthold, Guillaume, Horowitz, Peleg, Loda, Massimo, Beroukhim, Rameen, Agarwal, Shivani, Sengupta, Shiladitya, Sundaram, Mallikarjun, Majumder, Pradip K.

“…Predicting clinical response to anticancer drugs remains a major challenge in cancer treatment. Emerging reports indicate that the tumour microenvironment and…”
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Editor's Note: Androgen-Induced Differentiation and Tumorigenicity of Human Prostate Epithelial Cells by Berger, Raanan, Febbo, Phillip G, Majumder, Pradip K, Zhao, Jean J, Mukherjee, Shayan, Signoretti, Sabina, Thirza Campbell, K, Sellers, William R, Roberts, Thomas M, Loda, Massimo, Golub, Todd R, Hahn, William C

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A Prostatic Intraepithelial Neoplasia-Dependent p27Kip1 Checkpoint Induces Senescence and Inhibits Cell Proliferation and Cancer Progression by Majumder, Pradip K, Grisanzio, Chiara, O'Connell, Fionnuala, Barry, Marc, Brito, Joseph M, Xu, Qing, Guney, Isil, Berger, Raanan, Herman, Paula, Bikoff, Rachel, Fedele, Giuseppe, Baek, Won-Ki, Wang, Shunyou, Ellwood-Yen, Katharine, Wu, Hong, Sawyers, Charles L, Signoretti, Sabina, Hahn, William C, Loda, Massimo, Sellers, William R

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Akt-regulated pathways in prostate cancer by Majumder, Pradip K, Sellers, William R

“…Prostate cancer remains a major cause of cancer-related mortality. Genetic clues to the molecular pathways driving the most aggressive forms of prostate cancer…”
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Lupeol and Paclitaxel cooperate in hindering hypoxia induced vasculogenic mimicry via suppression of HIF-1α-EphA2-Laminin-5γ2 network in human oral cancer by Saha, Depanwita, Mitra, Debarpan, Alam, Neyaz, Sen, Sagar, Mustafi, Saunak Mitra, Majumder, Pradip K., Majumder, Biswanath, Murmu, Nabendu

“…Vasculogenic mimicry (VM), defined as an endothelial cell independent alternative mechanism of blood and nutrient supply by dysregulated tumor cells, is…”
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Identification of prostate cancer modifier pathways using parental strain expression mapping by Xu, Qing, Majumder, Pradip K, Ross, Kenneth, Shim, Yeonju, Golub, Todd R, Loda, Massimo, Sellers, William R

“…Inherited genetic risk factors play an important role in cancer. However, other than the Mendelian fashion cancer susceptibility genes found in familial cancer…”
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Activation of p38 Mitogen-activated Protein Kinase by PYK2/Related Adhesion Focal Tyrosine Kinase-dependent Mechanism by Pandey, P, Avraham, S, Kumar, S, Nakazawa, A, Place, A, Ghanem, L, Rana, A, Kumar, V, Majumder, P K, Avraham, H, Davis, R J, Kharbanda, S

“…The stress-activated p38 mitogen-activated protein kinase (p38 MAPK), a member of the subgroup of mammalian kinases, appears to play an important role in…”
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Targeting the Notch1 and mTOR pathways in a mouse T-ALL model by Cullion, Kathleen, Draheim, Kyle M., Hermance, Nicole, Tammam, Jennifer, Sharma, Vishva M., Ware, Christopher, Nikov, George, Krishnamoorthy, Veena, Majumder, Pradip K., Kelliher, Michelle A.

“…Mutations in NOTCH1 are frequently detected in patients with T-cell acute lymphoblastic leukemia (T-ALL) and in mouse T-ALL models. Treatment of mouse or human…”
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JAK-STAT inhibitor as a potential therapeutic opportunity in AML patients resistant to cytarabine and epigenetic therapy by Babu, Govind, Chaudhuri, Padmaparna, Rajappa, Manoj, Biswas, Manjusha, Sansar, Bipinesh, Rajegowda, Chethan, Radhakrishnan, Aneesha, Advani, Jayshree, Tewary, Biplab, Radhakrishnan, Padhma, Thiyagarajan, Saravanan, Chatterjee, Aditi, Upadhayaya, Ram Shankar, Majumder, Pradip K

“…The prognosis of AML is generally poor, with 5-year survival rate of 25%. There has been substantial progress in identification of new therapeutic targets,…”
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Inhibition of γ-Secretase Activity Inhibits Tumor Progression in a Mouse Model of Pancreatic Ductal Adenocarcinoma by Plentz, Ruben, Park, Ji–Sun, Rhim, Andrew D, Abravanel, Daniel, Hezel, Aram F, Sharma, Sreenath V, Gurumurthy, Sushma, Deshpande, Vikram, Kenific, Candia, Settleman, Jeffrey, Majumder, Pradip K, Stanger, Ben Z, Bardeesy, Nabeel

“…Background & Aims The Notch signaling pathway is required for the expansion of undifferentiated pancreatic progenitor cells during embryonic development and…”
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Differential Expression of SRY-Related HMG-Box Transcription Factor 2, Oligodendrocyte Lineage Transcription Factor 2, and Zinc Finger E‑Box Binding Homeobox 1 in Serum-Derived Extracellular Vesicles: Implications for Mithramycin Sensitivity and Targeted Therapy in High-Grade Glioma by Patnam, Sreekanth, Majumder, Biswanath, Joshi, Parth, Singh, Anula Divyash, Nagalla, Balakrishna, Kumar, Dilli, Biswas, Manjusha, Ranjan, Alok, Majumder, Pradip K., Rengan, Aravind Kumar, Kamath, Ajith V., Ray, Amitava, Manda, Sasidhar Venkata

“…Glioblastoma multiforme (GBM) is the most aggressive type of glioma and is often resistant to traditional therapies. Evidence suggests that glioma stem cells…”
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CDKN2A-p53 mediated antitumor effect of Lupeol in head and neck cancer by Bhattacharyya, Sayantan, Sekar, Vasanthakumar, Majumder, Biswanath, Mehrotra, Debapriya G, Banerjee, Samir, Bhowmick, Anup K, Alam, Neyaz, Mandal, Gautam K, Biswas, Jaydip, Majumder, Pradip K, Murmu, Nabendu

“…Purpose The tumor suppressor protein p53 is known to control cell cycle arrest and apoptosis. Lupeol is a phytochemical that has been found to induce apoptosis…”
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Downregulation of Notch Pathway by a γ-Secretase Inhibitor Attenuates AKT/Mammalian Target of Rapamycin Signaling and Glucose Uptake in an ERBB2 Transgenic Breast Cancer Model by EFFERSON, Clay L, WINKELMANN, Christopher T, BUSER, Carolyn, YEATMAN, Timothy, COPPOLA, Domenico, WINTER, Christopher, CLARK, Edwin A, DRAETTA, Giulio F, STRACK, Peter R, MAJUMDER, Pradip K, WARE, Christopher, SULLIVAN, Timothy, GIAMPAOLI, Saverio, TAMMAM, Jennifer, PATEL, Shailendra, MESITI, Giuseppe, REILLY, John F, GIBSON, Raymond E

“…ERBB2/neu and Notch signaling are known to be deregulated in many human cancers. However, pathway cross-talk and dependencies are not well understood. In this…”
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