Search Results - "MAJOR, Amy S"

How Oxidized Low-Density Lipoprotein Activates Inflammatory Responses by Rhoads, Jillian P, Major, Amy S

“…Cardiovascular disease (CVD) is the number one cause of death in the United States and worldwide. The most common cause of cardiovascular disease is…”
Get full text

Fine tuning of immunometabolism for the treatment of rheumatic diseases by Rhoads, Jillian P., Major, Amy S., Rathmell, Jeffrey C.

“…The pathways by which cells modulate metabolism to attain optimal effector responses present numerous potential therapeutic targets in the context of rheumatic…”
Get full text

Local effects of human PCSK9 on the atherosclerotic lesion by Giunzioni, Ilaria, Tavori, Hagai, Covarrubias, Roman, Major, Amy S, Ding, Lei, Zhang, Youmin, DeVay, Rachel M, Hong, Liang, Fan, Daping, Predazzi, Irene M, Rashid, Shirya, Linton, MacRae F, Fazio, Sergio

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes atherosclerosis by increasing low‐density lipoprotein (LDL) cholesterol levels through…”
Get full text

Deletion of Macrophage LDL Receptor–Related Protein Increases Atherogenesis in the Mouse by Overton, Cheryl D, Yancey, Patricia G, Major, Amy S, Linton, MacRae F, Fazio, Sergio

“…Macrophage low-density lipoprotein receptor–related protein (LRP) mediates internalization of remnant lipoproteins, and it is generally thought that blocking…”
Get full text

Expanding the Therapeutic Frontier in Atherosclerosis by Major, Amy S.

Get full text

B-Lymphocyte Deficiency Increases Atherosclerosis in LDL Receptor–Null Mice by Major, Amy S, Fazio, Sergio, Linton, MacRae F

“…OBJECTIVE—Atherosclerosis is an inflammatory disease characterized by innate and adaptive immune responses. We investigated the role of B cells and antibodies…”
Get full text

Specific deletion of LDL receptor-related protein on macrophages has skewed in vivo effects on cytokine production by invariant natural killer T cells by Covarrubias, Roman, Wilhelm, Ashley J, Major, Amy S

“…Expression of molecules involved in lipid homeostasis such as the low density lipoprotein receptor (LDLr) on antigen presenting cells (APCs) has been shown to…”
Get full text

Angiotensin type 1 receptor modulates macrophage polarization and renal injury in obesity by Ma, Li-Jun, Corsa, Bridgette A, Zhou, Jun, Yang, HaiChun, Li, HaiJing, Tang, Yi-Wei, Babaev, Vladimir R, Major, Amy S, Linton, MacRae F, Fazio, Sergio, Hunley, Tracy E, Kon, Valentina, Fogo, Agnes B

“…The mechanisms for increased risk of chronic kidney disease (CKD) in obesity remain unclear. The renin-angiotensin system is implicated in the pathogenesis of…”
Get more information

Metabolic preconditioning in CD4+ T cells restores inducible immune tolerance in lupus-prone mice by Wilson, Christopher S, Stocks, Blair T, Hoopes, Emilee M, Rhoads, Jillian P, McNew, Kelsey L, Major, Amy S, Moore, Daniel J

“…Autoimmune disease has presented an insurmountable barrier to restoration of durable immune tolerance. Previous studies indicate that chronic therapy with…”
Get full text

Bone marrow deficiency of MCPIP1 results in severe multi-organ inflammation but diminishes atherogenesis in hyperlipidemic mice by Yu, Fang, Du, Fen, Wang, Yuzhen, Huang, Shengping, Miao, Ruidong, Major, Amy S, Murphy, E Angela, Fu, Mingui, Fan, Daping

“…MCPIP1 is a newly identified protein that profoundly impacts immunity and inflammation. We aim to test if MCPIP1 deficiency in hematopoietic cells results in…”
Get full text

High-fat diet-induced colonocyte dysfunction escalates microbiota-derived trimethylamine N -oxide by Yoo, Woongjae, Zieba, Jacob K, Foegeding, Nora J, Torres, Teresa P, Shelton, Catherine D, Shealy, Nicolas G, Byndloss, Austin J, Cevallos, Stephanie A, Gertz, Erik, Tiffany, Connor R, Thomas, Julia D, Litvak, Yael, Nguyen, Henry, Olsan, Erin E, Bennett, Brian J, Rathmell, Jeffrey C, Major, Amy S, Bäumler, Andreas J, Byndloss, Mariana X

“…A Western-style, high-fat diet promotes cardiovascular disease, in part because it is rich in choline, which is converted to trimethylamine (TMA) by the gut…”
Get full text

Accelerated atherosclerosis in systemic lupus erythematosus: don't forget the devil we know by van Leuven, Sander I, Major, Amy S

Get full text

Quantitative and Qualitative Differences in Proatherogenic NKT Cells in Apolipoprotein E–Deficient Mice by Major, Amy S, Wilson, Michael T, McCaleb, Jennifer L, Su, Yan Ru, Stanic, Aleksandar K, Joyce, Sebastian, Van Kaer, Luc, Fazio, Sergio, Linton, MacRae F

“…BACKGROUND—Atherosclerosis is a disease marked by lipid accumulation and inflammation. Recently, atherosclerosis has gained recognition as an autoimmune-type…”
Get full text

The latest in systemic lupus erythematosus-accelerated atherosclerosis: related mechanisms inform assessment and therapy by Appleton, Brenna D., Major, Amy S.

“…Accelerated atherosclerosis is a significant comorbidity and the leading cause of death for patients with systemic lupus erythematosus (SLE). It is now…”
Get full text

Immune Dysregulation Accelerates Atherosclerosis and Modulates Plaque Composition in Systemic Lupus Erythematosus by Stanic, Aleksandar K., Stein, Charles M., Morgan, Adam C., Fazio, Sergio, Linton, MacRae F., Wakeland, Edward K., Olsen, Nancy J., Major, Amy S.

“…Patients with systemic lupus erythematosus (SLE) have accelerated atherosclerosis. The underlying mechanisms are poorly understood, and investigations have…”
Get full text

FcγRIIb on CD11c+ cells modulates serum cholesterol and triglyceride levels and differentially affects atherosclerosis in male and female Ldlr−/− mice by Marvin, Jennifer, Rhoads, Jillian P., Major, Amy S.

“…Circulating levels of oxidized lipoprotein (oxLDL) correlate with myocardial infarction risk and atherosclerosis severity. Our previous study demonstrates that…”
Get full text

Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1 by YAN RU SU, DOVE, Dwayne E, MAJOR, Amy S, HASTY, Alyssa H, BOONE, Branden, LINTON, Macrae F, FAZIO, Sergio

“…Macrophage acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) and apolipoprotein E (apoE) have been implicated in regulating cellular cholesterol…”
Get full text

Oxidized Low-Density Lipoprotein Immune Complex Priming of the Nlrp3 Inflammasome Involves TLR and FcγR Cooperation and Is Dependent on CARD9 by Rhoads, Jillian P, Lukens, John R, Wilhelm, Ashley J, Moore, Jared L, Mendez-Fernandez, Yanice, Kanneganti, Thirumala-Devi, Major, Amy S

“…Oxidized low-density lipoprotein (oxLDL) is known to activate inflammatory responses in a variety of cells, especially macrophages and dendritic cells…”
Get full text

Oxidized Phospholipid oxPAPC Alters Regulatory T-Cell Differentiation and Decreases Their Protective Function in Atherosclerosis in Mice by Appleton, Brenna D, Palmer, Sydney A, Smith, Harrison P, Stephens, Lilly E, Major, Amy S

“…Regulatory T cells (T ) are protective in atherosclerosis but reduced during disease progression due to cell death and loss of stability. However, the…”
Get full text

Dysregulated CD4+ T cells from SLE-susceptible mice are sufficient to accelerate atherosclerosis in LDLr-/- mice by Wilhelm, Ashley J, Rhoads, Jillian P, Wade, Nekeithia S, Major, Amy S

“…Accelerated atherosclerosis is a major source of morbidity in systemic lupus erythematosus (SLE). However, the cause of SLE-accelerated atherosclerosis remains…”
Get more information