Search Results - "MAJEWSKI, J"

ROBUST HYPERPARAMETER ESTIMATION PROTECTS AGAINST HYPERVARIABLE GENES AND IMPROVES POWER TO DETECT DIFFERENTIAL EXPRESSION by Phipso, Belinda, Lee, Stanley, Majewski, Ian J., Alexander, Warren S., Smyth, Gordon K.

“…One of the most common analysis tasks in genomic research is to identify genes that are differentially expressed (DE) between experimental conditions…”
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The Dynamic Behaviour of Capacitive Humidity Sensors by J. Majewski

“…The sensor design features and the sensing material properties which can influence the response time of the polymer-based capacitive humidity sensors are…”
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The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism by Murphy, James M., Czabotar, Peter E., Hildebrand, Joanne M., Lucet, Isabelle S., Zhang, Jian-Guo, Alvarez-Diaz, Silvia, Lewis, Rowena, Lalaoui, Najoua, Metcalf, Donald, Webb, Andrew I., Young, Samuel N., Varghese, Leila N., Tannahill, Gillian M., Hatchell, Esme C., Majewski, Ian J., Okamoto, Toru, Dobson, Renwick C.J., Hilton, Douglas J., Babon, Jeffrey J., Nicola, Nicos A., Strasser, Andreas, Silke, John, Alexander, Warren S.

“…Mixed lineage kinase domain-like (MLKL) is a component of the “necrosome,” the multiprotein complex that triggers tumor necrosis factor (TNF)-induced cell…”
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Multilayered stable 2D nano-sheets of Ti2NTx MXene: synthesis, characterization, and anticancer activity by Szuplewska, A, RozmysÅowska-Wojciechowska, A, Poźniak, S, Wojciechowski, T, Birowska, M, Popielski, M, Chudy, M, Ziemkowska, W, Chlubny, L, MoszczyÅska, D, Olszyna, A, Majewski, J. A, JastrzÄbska, A. M

“…Abstract Background The biological activity of MXenes has been studied for several years because of their potential biomedical applications; however,…”
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Nickel–silica core@shell catalyst for methane reforming by Majewski, Artur J., Wood, Joseph, Bujalski, Waldemar

“…Steam reforming of methane from biogas at a small scale could potentially provide a source of hydrogen for applications such as electricity generation via fuel…”
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SuperFreq: Integrated mutation detection and clonal tracking in cancer by Flensburg, Christoffer, Sargeant, Tobias, Oshlack, Alicia, Majewski, Ian J

“…Analysing multiple cancer samples from an individual patient can provide insight into the way the disease evolves. Monitoring the expansion and contraction of…”
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Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations by Birkinshaw, Richard W., Gong, Jia-nan, Luo, Cindy S., Lio, Daisy, White, Christine A., Anderson, Mary Ann, Blombery, Piers, Lessene, Guillaume, Majewski, Ian J., Thijssen, Rachel, Roberts, Andrew W., Huang, David C. S., Colman, Peter M., Czabotar, Peter E.

“…Venetoclax is a first-in-class cancer therapy that interacts with the cellular apoptotic machinery promoting apoptosis. Treatment of patients suffering chronic…”
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The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism by Anderson, Mary Ann, Deng, Jing, Seymour, John F., Tam, Constantine, Kim, Su Young, Fein, Joshua, Yu, Lijian, Brown, Jennifer R., Westerman, David, Si, Eric G., Majewski, Ian J., Segal, David, Heitner Enschede, Sari L., Huang, David C.S., Davids, Matthew S., Letai, Anthony, Roberts, Andrew W.

“…BCL2 blunts activation of the mitochondrial pathway to apoptosis, and high-level expression is required for chronic lymphocytic leukemia (CLL) survival…”
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MINTIE: identifying novel structural and splice variants in transcriptomes using RNA-seq data by Cmero, Marek, Schmidt, Breon, Majewski, Ian J, Ekert, Paul G, Oshlack, Alicia, Davidson, Nadia M

“…Calling fusion genes from RNA-seq data is well established, but other transcriptional variants are difficult to detect using existing approaches. To identify…”
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Taming the dragon: genomic biomarkers to individualize the treatment of cancer by Bernards, René, Majewski, Ian J

“…The gradual shift from cytotoxic drugs to highly selective, targeted therapeutic agents for cancer requires a parallel effort to characterize cancers at the…”
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Finding a suitable library size to call variants in RNA-Seq by Quaglieri, Anna, Flensburg, Christoffer, Speed, Terence P, Majewski, Ian J

“…RNA sequencing allows the study of both gene expression changes and transcribed mutations, providing a highly effective way to gain insight into cancer…”
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Utility of whole-exome sequencing for those near the end of the diagnostic odyssey: time to address gaps in care by Sawyer, S.L., Hartley, T., Dyment, D.A., Beaulieu, C.L., Schwartzentruber, J., Smith, A., Bedford, H.M., Bernard, G., Bernier, F.P., Brais, B., Bulman, D.E., Warman Chardon, J., Chitayat, D., Deladoëy, J., Fernandez, B.A., Frosk, P., Geraghty, M.T., Gerull, B., Gibson, W., Gow, R.M., Graham, G.E., Green, J.S., Heon, E., Horvath, G., Innes, A.M., Jabado, N., Kim, R.H., Koenekoop, R.K., Khan, A., Lehmann, O.J., Mendoza-Londono, R., Michaud, J.L., Nikkel, S.M., Penney, L.S., Polychronakos, C., Richer, J., Rouleau, G.A., Samuels, M.E., Siu, V.M., Suchowersky, O., Tarnopolsky, M.A., Yoon, G., Zahir, F.R., Majewski, J., Boycott, K.M.

“…An accurate diagnosis is an integral component of patient care for children with rare genetic disease. Recent advances in sequencing, in particular whole‐exome…”
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Origin of bulk uniaxial anisotropy in zinc-blende dilute magnetic semiconductors by Birowska, M, Śliwa, C, Majewski, J A, Dietl, T

“…It is demonstrated that the nearest-neighbor Mn pair on the GaAs (001) surface has a lower energy for the [110] direction compared to the [110] case. According…”
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Whole exome sequencing unravels disease-causing genes in consanguineous families in Qatar by Fahiminiya, S., Almuriekhi, M., Nawaz, Z., Staffa, A., Lepage, P., Ali, R., Hashim, L., Schwartzentruber, J., Abu Khadija, K., Zaineddin, S., Gamal, H., Majewski, J., Ben-Omran, T.

“…Whole exome sequencing (WES) has greatly facilitated the identification of causal mutations for diverse human genetic disorders. We applied WES as a molecular…”
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CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation by Martin, Emmanuel, Palmic, Noé, Sanquer, Sylvia, Lenoir, Christelle, Hauck, Fabian, Mongellaz, Cédric, Fabrega, Sylvie, Nitschké, Patrick, Esposti, Mauro Degli, Schwartzentruber, Jeremy, Taylor, Naomi, Majewski, Jacek, Jabado, Nada, Wynn, Robert F., Picard, Capucine, Fischer, Alain, Arkwright, Peter D., Latour, Sylvain

“…Loss-of-function mutations in the human CTP synthase 1 gene cause an immunodeficiency disease with impaired T cell proliferation after antigen stimulation,…”
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Overexpression of Lmo2 initiates T-lymphoblastic leukemia via impaired thymocyte competition by Abdulla, Hesham D, Alserihi, Raed, Flensburg, Christoffer, Abeysekera, Waruni, Luo, Meng-Xiao, Gray, Daniel H D, Liu, Xiaodong, Smyth, Gordon K, Alexander, Warren S, Majewski, Ian J, McCormack, Matthew P

“…Cell competition has recently emerged as an important tumor suppressor mechanism in the thymus that inhibits autonomous thymic maintenance. Here, we show that…”
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Application of silver in microtubular solid oxide fuel cells by Majewski, Artur J., Dhir, Aman

“…In this paper, the behaviour of silver as cathode conductive material, interconnect wire, and sealing for anode lead connection for microtubular solid oxide…”
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Whole‐exome sequencing is a valuable diagnostic tool for inherited peripheral neuropathies: Outcomes from a cohort of 50 families by Hartley, T., Wagner, J.D., Warman‐Chardon, J., Tétreault, M., Brady, L., Baker, S., Tarnopolsky, M., Bourque, P.R., Parboosingh, J.S., Smith, C., McInnes, B., Innes, A.M., Bernier, F., Curry, C.J., Yoon, G., Horvath, G.A., Bareke, E., Gillespie, M., Majewski, J., Bulman, D.E., Dyment, D.A., Boycott, K.M.

“…The inherited peripheral neuropathies (IPNs) are characterized by marked clinical and genetic heterogeneity and include relatively frequent presentations such…”
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The BRCA1ness signature is associated significantly with response to PARP inhibitor treatment versus control in the I-SPY 2 randomized neoadjuvant setting by Severson, Tesa M, Wolf, Denise M, Yau, Christina, Peeters, Justine, Wehkam, Diederik, Schouten, Philip C, Chin, Suet-Feung, Majewski, Ian J, Michaut, Magali, Bosma, Astrid, Pereira, Bernard, Bismeijer, Tycho, Wessels, Lodewyk, Caldas, Carlos, Bernards, René, Simon, Iris M, Glas, Annuska M, Linn, Sabine, van 't Veer, Laura

“…Patients with BRCA1-like tumors correlate with improved response to DNA double-strand break-inducing therapy. A gene expression-based classifier was developed…”
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Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis by Lee, StanleyC.W., Miller, Sarah, Hyland, Craig, Kauppi, Maria, Lebois, Marion, Di Rago, Ladina, Metcalf, Donald, Kinkel, Sarah A., Josefsson, Emma C., Blewitt, Marnie E., Majewski, Ian J., Alexander, Warren S.

“…Polycomb repressive complex 2 (PRC2) is a chromatin modifier that regulates stem cells in embryonic and adult tissues. Loss-of-function studies of PRC2…”
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