Search Results - "MAJCHRZAK, M. J"

Preclinical characterization of selective phosphodiesterase 10A inhibitors: a new therapeutic approach to the treatment of schizophrenia by Schmidt, C J, Chapin, D S, Cianfrogna, J, Corman, M L, Hajos, M, Harms, J F, Hoffman, W E, Lebel, L A, McCarthy, S A, Nelson, F R, Proulx-LaFrance, C, Majchrzak, M J, Ramirez, A D, Schmidt, K, Seymour, P A, Siuciak, J A, Tingley, 3rd, F D, Williams, R D, Verhoest, P R, Menniti, F S

“…We have recently proposed the hypothesis that inhibition of the cyclic nucleotide phosphodiesterase (PDE) 10A may represent a new pharmacological approach to…”
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Peripheral Administration of a Long-Acting Peptide Oxytocin Receptor Agonist Inhibits Fear-Induced Freezing by Modi, Meera E, Majchrzak, Mark J, Fonseca, Kari R, Doran, Angela, Osgood, Sarah, Vanase-Frawley, Michelle, Feyfant, Eric, McInnes, Heather, Darvari, Ramin, Buhl, Derek L, Kablaoui, Natasha M

“…Oxytocin (OT) modulates the expression of social and emotional behaviors and consequently has been proposed as a pharmacologic treatment of psychiatric…”
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Effects of lobeline, a nicotinic receptor agonist, on learning and memory by Decker, M W, Majchrzak, M J, Arnerić, S P

“…The effects of (-)-lobeline were assessed in two learning and memory tasks in which nicotine-induced enhancement of performance has previously been…”
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Effects of systemic and intracerebroventricular administration of mecamylamine, a nicotinic cholinergic antagonist, on spatial memory in rats by DECKER, M. W, MAJCHRZAK, M. J

“…The effects of both systemic and intracerebroventricular administration of mecamylamine, a nicotinic antagonist, were tested on the Morris water maze…”
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The effects of morphine on diet selection are dependent upon baseline diet preferences by Gosnell, B A, Krahn, D D, Majchrzak, M J

“…It has been reported that morphine causes a selective increase in the intake of dietary fat. Because we have noted considerable variability among rats in their…”
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Mecamylamine pretreatment increases subsequent nicotine self-administration as indicated by changes in plasma nicotine level by POMERLEAU, C. S, POMERLEAU, O. F, MAJCHRZAK, M. J

“…Acute administration of mecamylamine, a centrally active nicotinic cholinergic agonist, has been shown to increase amount of smoking as indicated by smoking…”
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Centrally administered opioid peptides stimulate saccharin intake in nondeprived rats by Gosnell, B A, Majchrzak, M J

“…Endogenous opioid peptides are thought to play a role in mediating the pleasurable or rewarding aspects of the ingestion of certain foods and liquids. We…”
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Relationship between nicotine tolerance questionnaire scores and plasma cotinine by Pomerleau, C S, Pomerleau, O F, Majchrzak, M J, Kloska, D D, Malakuti, R

“…The Fagerström Tolerance Questionnaire (TQ) is often used in both research and treatment contexts to evaluate nicotine tolerance and physiological dependence…”
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Effects of a selective mu opioid receptor agonist and naloxone on the intake of sodium chloride solutions by GOSNELL, B. A, MAJCHRZAK, M. J

“…Endogenous opioid peptides are thought to play a role in mediating the palatability or rewarding aspects of sweet tastes. There is also evidence, however,…”
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Effects of placebo (saline) injections on core temperature in the rat by Dilsaver, S C, Majchrzak, M J

“…1. Core temperature was telemetrically measured in 15 rats before (i.e., at baseline) and at 10-min intervals for 120 min following the injection of normal…”
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Effects of preferential delta and kappa opioid receptor agonists on the intake of hypotonic saline by Gosnell, B A, Majchrzak, M J, Krahn, D D

“…A previous study has implicated central mu opioid receptors in the preference for salt solutions. Because mu, kappa and delta receptors are all thought to play…”
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Chronic treatment with ethanol alters the physiological action of nicotine by Majchrzak, M J, Dilsaver, S C

“…1. Ethanol decreases the release of acetylcholine through effects on presynaptic neurons at both muscarinic and nicotinic junctions. 2. Blockade of the release…”
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Bright artificial light subsensitizes a central muscarinic mechanism by Dilsaver, S C, Majchrzak, M J

“…Supersensitivity of a muscarinic mechanism is implicated in the pathophysiology of depression. Bright artificial light is efficacious in the treatment of…”
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Effects of bright light on adrenergic and cholinergic systems by Majchrzak, M J, Dilsaver, S C

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Bright artificial light produces subsensitivity to nicotine by Dilsaver, S C, Majchrzak, M J

“…Bright artificial light is a treatment for seasonal depression. Eleven (11) rats were exposed to bright artificial light (11,500 lux) for two consecutive…”
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Bright light blocks amitriptyline-induced cholinoceptor supersensitivity by Dilsaver, S C, Majchrzak, M J, Flemmer, D

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Effects of nicotine on spatial memory deficits in rats with septal lesions by Decker, M W, Majchrzak, M J, Anderson, D J

“…Impaired septohippocampal function has been implicated in the memory deficits associated with Alzheimer's disease (AD), and septal lesions have been used to…”
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Synthesis, sar and pharmacology of CP-293,019 : A potent, selective dopamine D4 receptor antagonist by SANNER, M. A, CHAPPIE, T. A, MAJCHRZAK, M. J, FARACI, W. S, COLLINS, J. L, DUIGNAN, D. B, DI PRETE, C. C, LEE, J. S, TROZZI, A, DUNAISKIS, A. R, FLIRI, A. F, DESAI, K. A, ZORN, S. H, JACKSON, E. R, JOHNSON, C. G, MORRONE, J. M, SEYMOUR, P. A

“…A series of novel, potent and selective pyrido[1,2-a]pyrazine dopamine D4 receptor antagonists are reported including CP-293,019 (D4 Ki = 3.4 nM, D2 Ki > 3,310…”
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Telemetric measurement of core temperature in pharmacological research: validity and reliability by Dilsaver, S C, Majchrzak, M J, Alessi, N E

“…1. The authors present data establishing the reliability and validity of a method for telemetrically measuring core temperature. 2. The method is designed to…”
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Bright artificial light produces subsensitivity to clonidine by Dilsaver, S C, Majchrzak, M J

“…The authors used a thermoregulation paradigm to test the hypothesis that chronic treatment with bright artificial light produces subsensitivity to the…”
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