Search Results - "MAITA, Hiroshi"

Development of a Cell-Based Assay Using a Split-Luciferase Reporter for Compound Screening by Sato, Satoshi, Ariga, Hiroyoshi, Maita, Hiroshi

“…Recently, the finding of recurrent mutations in the spliceosome components in cancer has indicated that the spliceosome is a potential target for cancer…”
Get full text

What is the switch for coupling transcription and splicing? RNA Polymerase II C‐terminal domain phosphorylation, phase separation and beyond by Maita, Hiroshi, Nakagawa, Shinichi

“…Phosphorylation of the RNA polymerase II C‐terminal domain (Pol II CTD) has important roles in the kinetic coupling of splicing with transcription, which is…”
Get full text

BAY61-3606 Alters snRNP Composition and Enhances Usage of Suboptimal Splice Acceptor Site by Tomita, Kenji, Nakagawa, Shinichi, Ariga, Hiroyoshi, Maita, Hiroshi

“…Intron recognition by the spliceosome mainly depends on conserved intronic sequences such as 5′ splice sites, 3′ splice sites, and branch sites. Therefore,…”
Get full text

Neuroprotective Function of DJ-1 in Parkinson’s Disease by Ariga, Hiroyoshi, Takahashi-Niki, Kazuko, Kato, Izumi, Maita, Hiroshi, Niki, Takeshi, Iguchi-Ariga, Sanae M. M.

“…Parkinson’s disease (PD) is caused by dopaminergic neuronal death in the substantia nigra, resulting in a reduced level of dopamine in the striatum. Oxidative…”
Get full text

DJ-1 binds to mitochondrial complex I and maintains its activity by Hayashi, Takuya, Ishimori, Chikako, Takahashi-Niki, Kazuko, Taira, Takahiro, Kim, Yun-chul, Maita, Hiroshi, Maita, Chinatsu, Ariga, Hiroyoshi, Iguchi-Ariga, Sanae M.M.

“…Parkinson’s disease (PD) is caused by neuronal cell death, and oxidative stress and mitochondrial dysfunction are thought to be responsible for onset of PD…”
Get full text

Oxidized DJ-1 Inhibits p53 by Sequestering p53 from Promoters in a DNA-Binding Affinity-Dependent Manner by Kato, Izumi, Maita, Hiroshi, Takahashi-Niki, Kazuko, Saito, Yoshiro, Noguchi, Noriko, Iguchi-Ariga, Sanae M. M., Ariga, Hiroyoshi

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Exon ligation is proofread by the DExD/H-box ATPase Prp22p by Staley, Jonathan P, Mayas, Rabiah M, Maita, Hiroshi

“…To produce messenger RNA, the spliceosome excises introns from precursor (pre)-mRNA and splices the flanking exons. To establish fidelity, the spliceosome…”
Get full text

Spliceosome discards intermediates via the DEAH box ATPase Prp43p by Mayas, Rabiah M, Maita, Hiroshi, Semlow, Daniel R, Staley, Jonathan P

“…To promote fidelity in nuclear pre-mRNA splicing, the spliceosome rejects and discards suboptimal substrates that have engaged the spliceosome. Whereas DExD/H…”
Get full text

Epidermal Growth Factor-dependent Activation of the Extracellular Signal-regulated Kinase Pathway by DJ-1 Protein through Its Direct Binding to c-Raf Protein by Takahashi-Niki, Kazuko, Kato-Ose, Izumi, Murata, Hiroaki, Maita, Hiroshi, Iguchi-Ariga, Sanae M.M., Ariga, Hiroyoshi

“…DJ-1 is an oncogene and also a causative gene for familial Parkinson disease. DJ-1 has various functions, and the oxidative status of cysteine at position 106…”
Get full text

Monomer DJ-1 and its N-terminal sequence are necessary for mitochondrial localization of DJ-1 mutants by Maita, Chinatsu, Maita, Hiroshi, Iguchi-Ariga, Sanae M M, Ariga, Hiroyoshi

“…DJ-1 is a novel oncogene and also a causative gene for familial Parkinson's disease (park7). DJ-1 has multiple functions that include transcriptional…”
Get full text

Prefoldin Plays a Role as a Clearance Factor in Preventing Proteasome Inhibitor-induced Protein Aggregation by Abe, Akira, Takahashi-Niki, Kazuko, Takekoshi, Yuka, Shimizu, Takashi, Kitaura, Hirotake, Maita, Hiroshi, Iguchi-Ariga, Sanae M.M., Ariga, Hiroyoshi

“…Prefoldin is a molecular chaperone composed of six subunits, PFD1–6, and prevents misfolding of newly synthesized nascent polypeptides. Although it is…”
Get full text

Oxidative Status of DJ-1-dependent Activation of Dopamine Synthesis through Interaction of Tyrosine Hydroxylase and 4-Dihydroxy-l-phenylalanine (l-DOPA) Decarboxylase with DJ-1 by Ishikawa, Shizuma, Taira, Takahiro, Niki, Takeshi, Takahashi-Niki, Kazuko, Maita, Chinatsu, Maita, Hiroshi, Ariga, Hiroyoshi, Iguchi-Ariga, Sanae M.M.

“…Parkinson disease (PD) is caused by loss of dopamine, which is synthesized from tyrosine by two enzymes, tyrosine hydroxylase (TH) and…”
Get full text

DJ-1–Mediated Protective Effect of Protocatechuic Aldehyde Against Oxidative Stress in SH-SY5Y Cells by Gao, Jian-Wei, Yamane, Takuya, Maita, Hiroshi, Ishikawa, Shizuma, Iguchi-Ariga, Sanae M.M., Pu, Xiao-Ping, Ariga, Hiroyoshi

“…DJ-1 was identified as a causal gene for a familial form of early onset Parkinson’s disease (PD), park 7. DJ-1 plays roles in transcriptional regulation and…”
Get full text

Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson's disease and stroke model rats by Kitamura, Yoshihisa, Watanabe, Shotaro, Taguchi, Masanobu, Takagi, Kentaro, Kawata, Takuya, Takahashi-Niki, Kazuko, Yasui, Hiroyuki, Maita, Hiroshi, Iguchi-Ariga, Sanae Mm, Ariga, Hiroyoshi

“…Parkinson's disease (PD) and cerebral ischemia are chronic and acute neurodegenerative diseases, respectively, and onsets of these diseases are thought to be…”
Get full text

Tenascin-X Induces Cell Detachment through p38 Mitogen-Activated Protein Kinase Activation by Fujie, Shinpei, Maita, Hiroshi, Ariga, Hiroyoshi, Matsumoto, Ken-ichi

“…Extracellular matrix glycoprotein tenascin-X (TNX) is the largest member of the tenascin family. In this study, we investigated the adhesive properties of TNX…”
Get full text

PAP-1, the mutated gene underlying the RP9 form of dominant retinitis pigmentosa, is a splicing factor by Maita, Hiroshi, Kitaura, Hirotake, Keen, T. Jeffrey, Inglehearn, Chris F., Ariga, Hiroyoshi, Iguchi-Ariga, Sanae M.M.

“…PAP-1 is an in vitro phosphorylation target of the Pim-1 oncogene. Although PAP-1 binds to Pim-1, it is not a substrate for phosphorylation by Pim-1 in vivo…”
Get full text

Specific cleavage of DJ-1 under an oxidative condition by Ooe, Hiromasa, Maita, Chinatsu, Maita, Hiroshi, Iguchi-Ariga, Sanae M.M., Ariga, Hiroyoshi

“…DJ-1 was initially identified by us as a novel oncogene and has recently been found to be a causative gene for familial Parkinson's disease (PD) PARK7. DJ-1…”
Get full text

Association of PAP-1 and Prp3p, the products of causative genes of dominant retinitis pigmentosa, in the tri-snRNP complex by Maita, Hiroshi, Kitaura, Hirotake, Ariga, Hiroyoshi, Iguchi-Ariga, Sanae M.M.

“…PAP-1 has been identified by us as a Pim-1-binding protein and has recently been implicated as the defective gene in RP9, one type of autosomal dominant…”
Get full text

Dissecting the role of SMN multimerization in its dissociation from the Cajal body using harmine as a tool compound by Ohazama, Saki, Fujimoto, Akiko, Konda, Daisuke, Yokoyama, Ryota, Nakagawa, Shinichi, Maita, Hiroshi

“…Survival motor neuron protein (SMN), which is linked to spinal muscular atrophy, is a key component of the Gemin complex, which is essential for the assembly…”
Get full text

The cell type‐specific ER membrane protein UGS148 is not essential in mice by Takahashi, Osamu, Tanahashi, Mayuko, Yokoi, Saori, Kaneko, Mari, Yanaka, Kaori, Nakagawa, Shinichi, Maita, Hiroshi

“…Genomes of higher eukaryotes encode many uncharacterized proteins, and the functions of these proteins cannot be predicted from the primary sequences due to a…”
Get full text