Search Results - "MAIER, Carolina M"

Oxidative stress in ischemic brain damage: mechanisms of cell death and potential molecular targets for neuroprotection by Chen, Hai, Yoshioka, Hideyuki, Kim, Gab Seok, Jung, Joo Eun, Okami, Nobuya, Sakata, Hiroyuki, Maier, Carolina M, Narasimhan, Purnima, Goeders, Christina E, Chan, Pak H

“…Significant amounts of oxygen free radicals (oxidants) are generated during cerebral ischemia/reperfusion, and oxidative stress plays an important role in…”
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Minocycline-preconditioned neural stem cells enhance neuroprotection after ischemic stroke in rats by Sakata, Hiroyuki, Niizuma, Kuniyasu, Yoshioka, Hideyuki, Kim, Gab Seok, Jung, Joo Eun, Katsu, Masataka, Narasimhan, Purnima, Maier, Carolina M, Nishiyama, Yasuhiro, Chan, Pak H

“…Transplantation of neural stem cells (NSCs) offers a novel therapeutic strategy for stroke; however, massive grafted cell death following transplantation,…”
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Reperfusion and Neurovascular Dysfunction in Stroke: from Basic Mechanisms to Potential Strategies for Neuroprotection by Jung, Joo Eun, Kim, Gab Seok, Chen, Hai, Maier, Carolina M, Narasimhan, Purnima, Song, Yun Seon, Niizuma, Kuniyasu, Katsu, Masataka, Okami, Nobuya, Yoshioka, Hideyuki, Sakata, Hiroyuki, Goeders, Christina E, Chan, Pak H

“…Effective stroke therapies require recanalization of occluded cerebral blood vessels. However, reperfusion can cause neurovascular injury, leading to cerebral…”
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Neural Stem Cells Genetically Modified to Overexpress Cu/Zn-Superoxide Dismutase Enhance Amelioration of Ischemic Stroke in Mice by SAKATA, Hiroyuki, NIIZUMA, Kuniyasu, WAKAI, Takuma, NARASIMHAN, Purnima, MAIER, Carolina M, CHAN, Pak H

“…The harsh host brain microenvironment caused by production of reactive oxygen species after ischemic reperfusion injury offers a significant challenge to…”
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Evaluating therapeutic targets for reperfusion-related brain hemorrhage by Maier, Carolina M., Hsieh, Lily, Crandall, Trisha, Narasimhan, Purnima, Chan, Pak H.

“…Objective Early reperfusion after an ischemic stroke can cause blood–brain barrier injury with subsequent cerebral edema and devastating brain hemorrhage…”
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Neuronal Death/Survival Signaling Pathways in Cerebral Ischemia by Sugawara, Taku, Fujimura, Miki, Noshita, Nobuo, Kim, Gyung Whan, Saito, Atsushi, Hayashi, Takeshi, Narasimhan, Purnima, Maier, Carolina M., Chan, Pak H.

“…Cumulative evidence suggests that apoptosis plays a pivotal role in cell death in vitro after hypoxia. Apoptotic cell death pathways have also been implicated…”
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Interleukin 6-preconditioned neural stem cells reduce ischaemic injury in stroke mice by SAKATA, Hiroyuki, NARASIMHAN, Purnima, NIIZUMA, Kuniyasu, MAIER, Carolina M, WAKAI, Takuma, CHAN, Pak H

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Oxidative stress and neuronal death/survival signaling in cerebral ischemia by Saito, Atsushi, Maier, Carolina M, Narasimhan, Purnima, Nishi, Tatsuro, Song, Yun Seon, Yu, Fengshan, Liu, Jing, Lee, Yong-Sun, Nito, Chikako, Kamada, Hiroshi, Dodd, Robert L, Hsieh, Lily B, Hassid, Benjamin, Kim, Esther E, González, Maricela, Chan, Pak H

“…It has been demonstrated by numerous studies that apoptotic cell death pathways are implicated in ischemic cerebral injury in ischemia models in vivo…”
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Neurodegeneration in Striatum Induced by the Mitochondrial Toxin 3-Nitropropionic Acid: Role of Matrix Metalloproteinase-9 in Early Blood-Brain Barrier Disruption? by Kim, Gyung W, Gasche, Yvan, Grzeschik, Susanna, Copin, Jean-Christophe, Maier, Carolina M, Chan, Pak H

“…Blood-brain barrier (BBB) dysfunction is a potential mechanism involved in progressive striatal damage induced by the mitochondrial excitotoxin,…”
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Oxidative Damage to the Endoplasmic Reticulum is Implicated in Ischemic Neuronal Cell Death by Hayashi, Takeshi, Saito, Atsushi, Okuno, Shuzo, Ferrand-Drake, Michel, Dodd, Robert L, Nishi, Tatsuro, Maier, Carolina M, Kinouchi, Hiroyuki, Chan, Pak H

“…The endoplasmic reticulum (ER), which plays important roles in apoptosis, is susceptible to oxidative stress. Because reactive oxygen species (ROS) are…”
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Akt/Bad signaling and motor neuron survival after spinal cord injury by Yu, Fengshan, Sugawara, Taku, Maier, Carolina M., Hsieh, Lily B., Chan, Pak H.

“…The serine–threonine kinase Akt is a cell survival signaling pathway that inactivates the proapoptotic BCL-2 family protein Bad and promotes cell survival in…”
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Interleukin 6-preconditioned neural stem cells reduce ischaemic injury in stroke mice by Sakata, Hiroyuki, Narasimhan, Purnima, Niizuma, Kuniyasu, Maier, Carolina M, Wakai, Takuma, Chan, Pak H

“…Transplantation of neural stem cells provides a promising therapy for stroke. Its efficacy, however, might be limited because of massive grafted-cell death…”
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Effects of Mild Hypothermia on Superoxide Anion Production, Superoxide Dismutase Expression, and Activity Following Transient Focal Cerebral Ischemia by Maier, Carolina M., Sun, Guo Hua, Cheng, Danye, Yenari, Midori A., Chan, Pak H., Steinberg, Gary K.

“…Following a transient ischemic insult there is a marked increase in free radical (FR) production within the first 10–15 min of reperfusion and again at the…”
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Assessment of the proliferative, apoptotic and cellular renovation indices of the human mammary epithelium during the follicular and luteal phases of the menstrual cycle by Navarrete, Maria Alicia H, Maier, Carolina M, Falzoni, Roberto, Quadros, Luiz Gerk de Azevedo, Lima, Geraldo R, Baracat, Edmund C, Nazário, Afonso C P

“…During the menstrual cycle, the mammary gland goes through sequential waves of proliferation and apoptosis. In mammary epithelial cells, hormonal and…”
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Role of superoxide dismutases in oxidative damage and neurodegenerative disorders by Maier, Carolina M, Chan, Pak H

“…In recent years, oxidative stress has been implicated in a variety of degenerative processes, diseases, and syndromes. Some of these include atherosclerosis,…”
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Prevention of JNK Phosphorylation as a Mechanism for Rosiglitazone in Neuroprotection after Transient Cerebral Ischemia: Activation of Dual Specificity Phosphatase by Okami, Nobuya, Narasimhan, Purnima, Yoshioka, Hideyuki, Sakata, Hiroyuki, Kim, Gab Seok, Jung, Joo Eun, Maier, Carolina M, Chan, Pak H

“…Rosiglitazone, a synthetic peroxisome proliferator-activated receptor-γ (PPARγ) agonist, prevents cell death after cerebral ischemia in animal models, but the…”
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The protective effect of early hypothermia on PTEN phosphorylation correlates with free radical inhibition in rat stroke by Lee, Sang Mi, Zhao, Heng, Maier, Carolina M, Steinberg, Gary K

“…We recently showed that intraischemic moderate hypothermia (30°C) reduces ischemic damage through the Akt pathway after permanent distal middle cerebral artery…”
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Matrix metalloproteinase-9 and myeloperoxidase expression: Quantitative analysis by antigen immunohistochemistry in a model of transient focal cerebral ischemia by MAIER, Carolina M, HSIEH, Lily, FENGSHAN YU, BRACCI, Paige, CHAN, Pak H

“…Expression of matrix metalloproteinases (MMPs), proteolytic enzymes that degrade extracellular proteins, is altered after ischemia/reperfusion injury and may…”
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Superoxide Dismutase 1 Overexpression Reduces MCP-1 and MIP-1α Expression after Transient Focal Cerebral Ischemia by Nishi, Tatsuro, Maier, Carolina M, Hayashi, Takeshi, Saito, Atsushi, Chan, Pak H

“…Proinflammatory cytokines and chemokines are quickly upregulated in response to ischemia/reperfusion (I/R) injury; however, the relationship between…”
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Optimal depth and duration of mild hypothermia in a focal model of transient cerebral ischemia: effects on neurologic outcome, infarct size, apoptosis, and inflammation by Maier, C M, Ahern, K v, Cheng, M L, Lee, J E, Yenari, M A, Steinberg, G K

“…Mild hypothermia is possibly the single most effective method of cerebroprotection developed to date. However, many questions regarding mild hypothermia remain…”
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