Search Results - "MAI, Elaine"

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates by Shen, Ben-Quan, Xu, Keyang, Liu, Luna, Raab, Helga, Bhakta, Sunil, Kenrick, Margaret, Parsons-Reponte, Kathryn L, Tien, Janet, Yu, Shang-Fan, Mai, Elaine, Li, Dongwei, Tibbitts, Jay, Baudys, Jakub, Saad, Ola M, Scales, Suzie J, McDonald, Paul J, Hass, Philip E, Eigenbrot, Charles, Nguyen, Trung, Solis, Willy A, Fuji, Reina N, Flagella, Kelly M, Patel, Darshana, Spencer, Susan D, Khawli, Leslie A, Ebens, Allen, Wong, Wai Lee, Vandlen, Richard, Kaur, Surinder, Sliwkowski, Mark X, Scheller, Richard H, Polakis, Paul, Junutula, Jagath R

“…Conjugating drugs to therapeutic antibodies is a promising strategy to increase their therapeutic efficacy. Shen et al. show that the local chemical…”
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The effect of different linkers on target cell catabolism and pharmacokinetics/pharmacodynamics of trastuzumab maytansinoid conjugates by Erickson, Hans K, Lewis Phillips, Gail D, Leipold, Douglas D, Provenzano, Carmela A, Mai, Elaine, Johnson, Holly A, Gunter, Bert, Audette, Charlene A, Gupta, Manish, Pinkas, Jan, Tibbitts, Jay

“…Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate consisting of the anti-HER2 antibody trastuzumab linked via a nonreducible thioether linker to the…”
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Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent by Merchant, Mark, Ma, Xiaolei, Maun, Henry R, Zheng, Zhong, Peng, Jing, Romero, Mally, Huang, Arthur, Yang, Nai-ying, Nishimura, Merry, Greve, Joan, Santell, Lydia, Zhang, Yu-Wen, Su, Yanli, Kaufman, Dafna W, Billeci, Karen L, Mai, Elaine, Moffat, Barbara, Lim, Amy, Duenas, Eileen T, Phillips, Heidi S, Xiang, Hong, Young, Judy C, Vande Woude, George F, Dennis, Mark S, Reilly, Dorothea E, Schwall, Ralph H, Starovasnik, Melissa A, Lazarus, Robert A, Yansura, Daniel G

“…Binding of hepatocyte growth factor (HGF) to the receptor tyrosine kinase MET is implicated in the malignant process of multiple cancers, making disruption of…”
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Trastuzumab uptake and its relation to efficacy in an animal model of HER2-positive breast cancer brain metastasis by Lewis Phillips, Gail D., Nishimura, Merry C., Lacap, Jennifer Arca, Kharbanda, Samir, Mai, Elaine, Tien, Janet, Malesky, Kimberly, Williams, Simon P., Marik, Jan, Phillips, Heidi S.

“…Purpose The extent to which efficacy of the HER2 antibody Trastuzumab in brain metastases is limited by access of antibody to brain lesions remains a question…”
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MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival by Jin, Hongkui, Yang, Renhui, Zheng, Zhong, Romero, Mally, Ross, Jed, Bou-Reslan, Hani, Carano, Richard A D, Kasman, Ian, Mai, Elaine, Young, Judy, Zha, Jiping, Zhang, Zemin, Ross, Sarajane, Schwall, Ralph, Colbern, Gail, Merchant, Mark

“…The hepatocyte growth factor (HGF) and its receptor, c-Met, have been implicated in driving proliferation, invasion, and poor prognosis in pancreatic cancer…”
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Development of an ultra-sensitive human IL-33 biomarker assay for age-related macular degeneration and asthma drug development by Mai, Elaine, Chan, Joyce, Goon, Levina, Ego, Braeden K, Bevers, Jack, Wong, Tiffany, Wong, Manda, Corpuz, Racquel, Xi, Hongkang, Wu, Jia, Schneider, Kellen, Seshasayee, Dhaya, Grimbaldeston, Michele, Nakamura, Gerald, Indjeian, Vahan B, van Lookeren Campagne, Menno, Loyet, Kelly M, Comps-Agrar, Laetitia

“…Over the past decade, human Interleukin 33 (hIL-33) has emerged as a key contributor to the pathogenesis of numerous inflammatory diseases. Despite the…”
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Modeling the efficacy of trastuzumab-DM1, an antibody drug conjugate, in mice by Jumbe, Nelson L., Xin, Yan, Leipold, Douglas D., Crocker, Lisa, Dugger, Debra, Mai, Elaine, Sliwkowski, Mark X., Fielder, Paul J., Tibbitts, Jay

“…Trastuzumab-DM1 (T-DM1) is a novel antibody–drug conjugate under investigation for the treatment of human epidermal growth factor receptor 2 (HER2)-positive…”
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Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele by Kauder, Steven E, Santell, Lydia, Mai, Elaine, Wright, Lilyan Y, Luis, Elizabeth, N'Diaye, Elsa N, Lutman, Jeff, Ratti, Navneet, Sa, Susan M, Maun, Henry R, Stefanich, Eric, Gonzalez, Lino C, Graham, Robert R, Diehl, Lauri, Faubion, Jr, William A, Keir, Mary E, Young, Judy, Chaudhuri, Amitabha, Lazarus, Robert A, Egen, Jackson G

“…Macrophage stimulating protein (MSP) is a serum growth factor that binds to and activates the receptor tyrosine kinase, Recepteur d'Origine Nantais (RON). A…”
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HER2-Targeted Therapy Reduces Incidence and Progression of Midlife Mammary Tumors in Female Murine Mammary Tumor Virus huHER2-Transgenic Mice by FINKLE, David, ZHI RICKY QUAN, ERICKSON, Sharon, ASGHARI, Vida, KLOSS, Jessica, GHABOOSI, Nazli, MAI, Elaine, WAI LEE WONG, HOLLINGSHEAD, Philip, SCHWALL, Ralph, KOEPPEN, Hartmut

“…Purpose: This study examined the effectiveness of early and prolonged mu4D5 (the murine form of trastuzumab/Herceptin) treatment in transgenic mice that…”
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Antibody targeting of E3 ubiquitin ligases for receptor degradation by Marei, Hadir, Tsai, Wen-Ting K., Kee, Yee-Seir, Ruiz, Karen, He, Jieyan, Cox, Chris, Sun, Tao, Penikalapati, Sai, Dwivedi, Pankaj, Choi, Meena, Kan, David, Saenz-Lopez, Pablo, Dorighi, Kristel, Zhang, Pamela, Kschonsak, Yvonne T., Kljavin, Noelyn, Amin, Dhara, Kim, Ingrid, Mancini, Andrew G., Nguyen, Thao, Wang, Chunling, Janezic, Eric, Doan, Alexander, Mai, Elaine, Xi, Hongkang, Gu, Chen, Heinlein, Melanie, Biehs, Brian, Wu, Jia, Lehoux, Isabelle, Harris, Seth, Comps-Agrar, Laetitia, Seshasayee, Dhaya, de Sauvage, Frederic J., Grimmer, Matthew, Li, Jing, Agard, Nicholas J., de Sousa e Melo, Felipe

“…Most current therapies that target plasma membrane receptors function by antagonizing ligand binding or enzymatic activities. However, typical mammalian…”
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Anti-CD20/CD3 T cell-dependent bispecific antibody for the treatment of B cell malignancies by Sun, Liping L, Ellerman, Diego, Mathieu, Mary, Hristopoulos, Maria, Chen, Xiaocheng, Li, Yijin, Yan, Xiaojie, Clark, Robyn, Reyes, Arthur, Stefanich, Eric, Mai, Elaine, Young, Judy, Johnson, Clarissa, Huseni, Mahrukh, Wang, Xinhua, Chen, Yvonne, Wang, Peiyin, Wang, Hong, Dybdal, Noel, Chu, Yu-Waye, Chiorazzi, Nicholas, Scheer, Justin M, Junttila, Teemu, Totpal, Klara, Dennis, Mark S, Ebens, Allen J

“…Bispecific antibodies and antibody fragments in various formats have been explored as a means to recruit cytolytic T cells to kill tumor cells. Encouraging…”
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Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate by Lewis Phillips, Gail D, Li, Guangmin, Dugger, Debra L, Crocker, Lisa M, Parsons, Kathryn L, Mai, Elaine, Blättler, Walter A, Lambert, John M, Chari, Ravi V J, Lutz, Robert J, Wong, Wai Lee T, Jacobson, Frederic S, Koeppen, Hartmut, Schwall, Ralph H, Kenkare-Mitra, Sara R, Spencer, Susan D, Sliwkowski, Mark X

“…HER2 is a validated target in breast cancer therapy. Two drugs are currently approved for HER2-positive breast cancer: trastuzumab (Herceptin), introduced in…”
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A novel, label‐free, pre‐equilibrium assay to determine the association and dissociation rate constants of therapeutic antibodies on living cells by Janezic, Eric M., Doan, Alexander, Mai, Elaine, Bravo, Daniel D., Wang, Jianyong, Kim, Hok Seon, Spiess, Christoph, Bewley, Kathryn, ElSohly, Adel, Liang, Wei‐Ching, Koerber, James T., Richalet, Pascale, Vanhove, Marc, Comps‐Agrar, Laetitia

“…Background and Purpose Monoclonal antibodies (Ab) represent the fastest growing drug class. Knowledge of the biophysical parameters (kon, koff and KD) that…”
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Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer by Lin, WeiYu, Xu, Daqi, Austin, Cary D, Caplazi, Patrick, Senger, Kate, Sun, Yonglian, Jeet, Surinder, Young, Judy, Delarosa, Donnie, Suto, Eric, Huang, Zhiyu, Zhang, Juan, Yan, Donghong, Corzo, Cesar, Barck, Kai, Rajan, Sharmila, Looney, Carrie, Gandham, Vineela, Lesch, Justin, Liang, Wei-Ching, Mai, Elaine, Ngu, Hai, Ratti, Navneet, Chen, Yongmei, Misner, Dinah, Lin, Tori, Danilenko, Dimitry, Katavolos, Paula, Doudemont, Estelle, Uppal, Hirdesh, Eastham, Jeffrey, Mak, Judy, de Almeida, Patricia E, Bao, Katherine, Hadadianpour, Azadeh, Keir, Mary, Carano, Richard A D, Diehl, Lauri, Xu, Min, Wu, Yan, Weimer, Robby M, DeVoss, Jason, Lee, Wyne P, Balazs, Mercedesz, Walsh, Kevin, Alatsis, Kathila R, Martin, Flavius, Zarrin, Ali A

“…Colony-stimulating factor 1 (CSF1) and interleukin 34 (IL34) signal the CSF1 receptor to regulate macrophage differentiation. Studies in IL34- or…”
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Engineered Thio-Trastuzumab-DM1 Conjugate with an Improved Therapeutic Index to Target Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer by JUNUTULA, Jagath R, FLAGELLA, Kelly M, MAI, Elaine, LEWIS PHILLIPS, Gail D, HIRARAGI, Hajime, FUJI, Reina N, TIBBITTS, Jay, VANDLEN, Richard, SPENCER, Susan D, SCHELLER, Richard H, POLAKIS, Paul, SLIWKOWSKI, Mark X, GRAHAM, Richard A, PARSONS, Kathryn L, HA, Edward, RAAB, Helga, BHAKTA, Sunil, NGUYEN, Trung, DUGGER, Debra L, GUANGMIN LI

“…Antibody drug conjugates (ADCs) combine the ideal properties of both antibodies and cytotoxic drugs by targeting potent drugs to the antigen-expressing tumor…”
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Characterization of the drug-to-antibody ratio distribution for antibody-drug conjugates in plasma/serum by Xu, Keyang, Liu, Luna, Dere, Randall, Mai, Elaine, Erickson, Rebecca, Hendricks, Angela, Lin, Kedan, Junutula, Jagath R, Kaur, Surinder

“…Antibody-drug conjugates (ADCs) are a new class of cancer therapeutics that deliver potent cytotoxins specifically to tumors to minimize systemic toxicity…”
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Anti-LYPD1/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Ovarian Cancer by Lo, Amy A, Johnston, Jennifer, Li, Ji, Mandikian, Danielle, Hristopoulos, Maria, Clark, Robyn, Nickles, Dorothee, Liang, Wei-Ching, Hötzel, Kathy, Dunlap, Debra, Pham, Thinh, Cai, Hao, Ovacik, Meric, Bravo-Perez, Daniel, Mai, Elaine, Slaga, Dionysos, Ellerman, Diego, Ziai, James, Totpal, Klara, Lee, Genee, Boswell, C Andrew, Payandeh, Jian, Wu, Yan, Junttila, Teemu T

“…Ovarian cancer is a diverse class of tumors with very few effective treatment options and suboptimal response rates in early clinical studies using…”
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Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for THIOMAB™ Drug Conjugates by Sukumaran, Siddharth, Gadkar, Kapil, Zhang, Crystal, Bhakta, Sunil, Liu, Luna, Xu, Keyang, Raab, Helga, Yu, Shang-Fan, Mai, Elaine, Fourie-O’Donohue, Aimee, Kozak, Katherine R., Ramanujan, Saroja, Junutula, Jagath R., Lin, Kedan

“…ABSTRACT Purpose THIOMAB™ drug conjugates (TDCs) with engineered cysteine residues allow site-specific drug conjugation and defined Drug-to-Antibody Ratios…”
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Measuring potency of bispecific effector/target-linking antibodies for inducing cytotoxicity of tumor cells using an impedance-based assay platform (P2094) by Young, Judy, Montgomery, Harley, Sun, Laura, Junttila, Teemu, Mai, Elaine

“…Cancer patients mount weak tumor-specific T-cell responses due to immune escape mechanisms of tumors. Although cytotoxic T-cells are potent killers, activation…”
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A novel method to produce synthetic murine CXCL10 for efficient screening of functional variants by Decalf, Jérémie, Tom, Jeffrey, Mai, Elaine, Hernandez-Barry, Hilda, Noland, Cameron L., Vollmar, Breanna S., Li, Alice, Li, Hong, Xie, Daniel, Zhu, Lunchao, Payandeh, Jian, Wu, Cong, Comps-Agrar, Laetitia, Moussion, Christine, Albert, Matthew L., Song, Aimin

“…[Display omitted] •Fmoc solid-phase peptide synthesis of murine CXCL10.•Flexible platform to generate natural and non-natural variants of murine…”
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