Search Results - "MAHLEY, R. W"

Apolipoprotein (apo) E4 and Alzheimer's disease: unique conformational and biophysical properties of apoE4 can modulate neuropathology by Mahley, R. W., Huang, Y.

“…The unique structural and biophysical features of apolipoprotein (apo) E4 – domain interaction and molten globule formation – have been correlated with the…”
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Putting cholesterol in its place: apoE and reverse cholesterol transport by Mahley, Robert W, Huang, Yadong, Weisgraber, Karl H

“…To avoid toxic overload of cholesterol in peripheral cells, the reverse cholesterol transport pathway directs excess cholesterol through HDL acceptors to the…”
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Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro by Nathan, B. P., Bellosta, S., Sanan, D. A., Weisgraber, K. H., Mahley, R. W., Pitas, R. E.

“…Apolipoprotein E4 (apoE4), one of the three common isoforms of apoE, has been implicated in Alzheimer's disease. The effects of apoE on neuronal growth were…”
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Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology by Mahley, Robert W.

“…Apolipoprotein E is a plasma protein that serves as a ligand for low density lipoprotein receptors and, through its interaction with these receptors,…”
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Turkish Heart Study: lipids, lipoproteins, and apolipoproteins by Mahley, R W, Palaoğlu, K E, Atak, Z, Dawson-Pepin, J, Langlois, A M, Cheung, V, Onat, H, Fulks, P, Mahley, L L, Vakar, F

“…We examined the plasma lipids, lipoproteins, and selected apolipoproteins in approximately 9,000 men and women from six different regions of Turkey with…”
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Low Density Lipoprotein Receptor-Related Protein Mediates Apolipoprotein E-Dependent Neurite Outgrowth in a Central Nervous System-Derived Neuronal Cell Line by Holtzman, David M., Pitas, Robert E., Kilbridge, Joshua, Nathan, Britto, Mahley, Robert W., Bu, Guojun, Schwartz, Alan L.

“…The ε4 allele of apolipoprotein E (apoE) is a major risk factor for Alzheimer disease, suggesting that apoE may directly influence neurons in the aging brain…”
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Secretion-capture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heparan sulfate proteoglycans by Ji, Z S, Fazio, S, Lee, Y L, Mahley, R W

“…To determine the impact of enhanced apolipoprotein (apo) E secretion on the mechanism of remnant lipoprotein uptake, rat hepatoma cells (McA-RH7777) were…”
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Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells by Ji, Z.S., Brecht, W.J., Miranda, R.D., Hussain, M.M., Innerarity, T.L., Mahley, R.W.

“…Addition of apolipoprotein (apo) E to rabbit beta-very low density lipoproteins (beta-VLDL) has been shown to result in a marked enhancement of their binding…”
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A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve by BOYLES, J. K, ZOELLNER, C. D, SHOOTER, E. M, ANDERSON, L. J, KOSIK, L. M, PITAS, R. E, WEISGRABER, K. H, HUI, D. Y, MAHLEY, R. W, GEBICKE-HAERTER, P. J, IGNATIUS, M. J

“…Recent work has demonstrated that apo E secretion and accumulation increase in the regenerating peripheral nerve. The fact that apoE, in conjunction with…”
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Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice by Bellosta, S, Mahley, R W, Sanan, D A, Murata, J, Newland, D L, Taylor, J M, Pitas, R E

“…apoE deficiency causes hyperlipidemia and premature atherosclerosis. To determine if macrophage-specific expression of apoE would decrease the extent of…”
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Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease by Buttini, M, Akeefe, H, Lin, C, Mahley, R.W, Pitas, R.E, Wyss-Coray, T, Mucke, L

“…Apolipoprotein E fulfills fundamental functions in lipid transport and neural tissue repair after injury. 6,8 Its three most common isoforms (E2, E3, and E4)…”
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Effects of apolipoprotein E, beta-very low density lipoproteins, and cholesterol on the extension of neurites by rabbit dorsal root ganglion neurons in vitro by Handelmann, GE, Boyles, JK, Weisgraber, KH, Mahley, RW, Pitas, RE

“…Previous studies suggest that during nerve regeneration apoE acts as a lipid transport protein that assists in the rapid initial extension of axons and then in…”
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DGAT1 promoter polymorphism associated with alterations in body mass index, high density lipoprotein levels and blood pressure in Turkish women by Ludwig, EH, Mahley, RW, Palaoglu, E, Özbayrakçı, S, Balestra, ME, Borecki, IB, Innerarity, TL, Farese Jr, RV

“…Triglyceride synthesis is catalyzed by acyl CoA:diacylglycerol acyltransferases (DGAT), microsomal enzymes that use diacylglycerol and fatty acyl CoAs as…”
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Overexpression of human apolipoprotein C-III in transgenic mice results in an accumulation of apolipoprotein B48 remnants that is corrected by excess apolipoprotein E by DE SILVA, H. V, LAUER, S. J, JAIJING WANG, SIMONET, W. S, WEISGRABER, K. H, MAHLEY, R. W, TAYLOR, J. M

“…Overexpression of human apolipoprotein (apo) C-III in the plasma of transgenic mice results in hypertriglyceridemia, with up to a 20-fold elevation in plasma…”
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Intravenous heparinase inhibits remnant lipoprotein clearance from the plasma and uptake by the liver: in vivo role of heparan sulfate proteoglycans by Ji, Z S, Sanan, D A, Mahley, R W

“…Heparan sulfate proteoglycans (HSPG) are involved in the binding and uptake of apolipoprotein (apo) E-enriched remnant lipoproteins by cultured cells in vitro…”
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Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein by KOWAL, R. C, HERZ, J, WEISGRABER, K. H, MAHLEY, R. W, BROWN, M. S, GOLDSTEIN, J. L

“…The low density lipoprotein receptor-related protein (LRP) from rat liver membranes binds apoprotein E (apoE)-enriched rabbit beta-migrating very low density…”
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Variable heparan sulfate proteoglycan binding of apolipoprotein E variants may modulate the expression of type III hyperlipoproteinemia by Ji, Z S, Fazio, S, Mahley, R W

“…The initial step in the clearance of apolipoprotein (apo) E-enriched remnant lipoproteins from the plasma appears to be sequestration within the liver mediated…”
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Three-Dimensional Structure of the LDL Receptor-Binding Domain of Human Apolipoprotein E by Wilson, Charles, Wardell, Mark R., Weisgraber, Karl H., Mahley, Robert W., Agard, David A.

“…Human apolipoprotein E, a blood plasma protein, mediates the transport and uptake of cholesterol and lipid by way of its high affinity interaction with…”
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Familial defective apolipoprotein B-100: a mutation of apolipoprotein B that causes hypercholesterolemia by Innerarity, TL, Mahley, RW, Weisgraber, KH, Bersot, TP, Krauss, RM, Vega, GL, Grundy, SM, Friedl, W, Davignon, J, McCarthy, BJ

“…Familial defective apolipoprotein B-100 is a genetic disorder of apolipoprotein B-100 that causes moderate to severe hypercholesterolemia. A single amino acid…”
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Overexpression of Hepatic Lipase in Transgenic Rabbits Leads to a Marked Reduction of Plasma High Density Lipoproteins and Intermediate Density Lipoproteins by Fan, Jianglin, Wang, Jiajin, Bensadoun, André, Lauer, Stephen J., Dang, Qi, Mahley, Robert W., Taylor, John M.

“…To elucidate the precise metabolic roles of hepatic lipase (HL), a human HL cDNA in a liver-specific expression vector was used to generate transgenic lines in…”
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