Search Results - "MAHER, Dermot"

Intravenous Ketamine Infusions for Neuropathic Pain Management: A Promising Therapy in Need of Optimization by Maher, Dermot P, Chen, Lucy, Mao, Jianren

“…Intravenous ketamine infusions have been used extensively to treat often-intractable neuropathic pain conditions. Because there are many widely divergent…”
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The ethics of feedback of HIV test results in population-based surveys of HIV infection by MAHER, Dermot

“…Population-based disease prevalence surveys raise ethical questions, including whether participants should be routinely told their test results. Ethical…”
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Supraspinal Mechanisms of Spinal Cord Stimulation for Modulation of Pain: Five Decades of Research and Prospects for the Future by Sivanesan, Eellan, Maher, Dermot P, Raja, Srinivasa N, Linderoth, Bengt, Guan, Yun

“…The field of spinal cord stimulation is expanding rapidly, with new waveform paradigms asserting supraspinal sites of action. The scope of treatment…”
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Suppression of Human Natural Killer Cells by Different Classes of Opioids by Maher, Dermot P., Walia, Deepa, Heller, Nicola M.

“…BACKGROUND:The use of regional and other opioid-sparing forms of anesthesia has been associated with a decrease in the recurrence of certain malignancies…”
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Morphine decreases the function of primary human natural killer cells by both TLR4 and opioid receptor signaling by Maher, Dermot P., Walia, Deepa, Heller, Nicola M.

“…•Morphine reduces NK cell induction of apoptosis in target tumor cells.•The decrease in NK cell function is blocked by opioid receptor and TLR4…”
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Estimates of Probabilities of Successful Development of Pain Medications: An Analysis of Pharmaceutical Clinical Development Programs from 2000 to 2020 by Maher, Dermot P., Wong, Chi Heem, Siah, Kien Wei, Lo, Andrew W.

“…Background The authors estimate the probability of successful development and duration of clinical trials for medications to treat neuropathic and nociceptive…”
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The human qualities needed to complete the global eradication of polio by MAHER, Dermot

“…Although the 99% decrease seen in global polio incidence between 1988 and 2000 represented remarkable progress towards polio eradication, tackling the last 1%…”
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Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa by Gurdasani, Deepti, Carstensen, Tommy, Fatumo, Segun, Chen, Guanjie, Franklin, Chris S., Prado-Martinez, Javier, Bouman, Heleen, Abascal, Federico, Haber, Marc, Tachmazidou, Ioanna, Mathieson, Iain, Ekoru, Kenneth, DeGorter, Marianne K., Nsubuga, Rebecca N., Finan, Chris, Wheeler, Eleanor, Chen, Li, Cooper, David N., Schiffels, Stephan, Chen, Yuan, Ritchie, Graham R.S., Pollard, Martin O., Fortune, Mary D., Mentzer, Alex J., Garrison, Erik, Bergström, Anders, Hatzikotoulas, Konstantinos, Adeyemo, Adebowale, Doumatey, Ayo, Elding, Heather, Wain, Louise V., Ehret, Georg, Auer, Paul L., Kooperberg, Charles L., Reiner, Alexander P., Franceschini, Nora, Maher, Dermot, Montgomery, Stephen B., Kadie, Carl, Widmer, Chris, Xue, Yali, Seeley, Janet, Asiki, Gershim, Kamali, Anatoli, Young, Elizabeth H., Pomilla, Cristina, Soranzo, Nicole, Zeggini, Eleftheria, Pirie, Fraser, Morris, Andrew P., Heckerman, David, Tyler-Smith, Chris, Motala, Ayesha A., Rotimi, Charles, Kaleebu, Pontiano, Barroso, Inês, Sandhu, Manj S.

“…Genomic studies in African populations provide unique opportunities to understand disease etiology, human diversity, and population history. In the largest…”
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Estimates of Probabilities of Successful Development of Pain Medications: An Analysis of Pharmaceutical Clinical Development Programs 2000-2020 by Maher, Dermot P., Wong, Chi Heem, Siah, Kien Wei, Lo, Andrew W.

“…We estimate the probability of successful development and duration of clinical trials for medications to treat neuropathic and nociceptive pain. We also…”
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Emerging concepts on the use of ketamine for chronic pain by Yang, Yunpeng, Maher, Dermot P, Cohen, Steven P

“…: The use of ketamine infusions for chronic pain has surged, with utilization exceeding the proliferation of knowledge. A proposed mechanism for the long-term…”
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Re-thinking global health sector efforts for HIV and tuberculosis epidemic control: promoting integration of programme activities within a strengthened health system by Maher, Dermot

“…The global financial crisis threatens global health, particularly exacerbating diseases of inequality, e.g. HIV/AIDS, and diseases of poverty, e.g…”
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Opioid Reduction Following Interventional Procedures for Chronic Pain: A Synthesis of the Evidence by Maher, Dermot P., Cohen, Steven P.

“…The past decade has witnessed the tremendous growth of procedures to treat chronic pain, which has resulted in increased third-party scrutiny. Although most of…”
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Cannabis for the Treatment of Chronic Pain in the Era of an Opioid Epidemic: A Symposium-Based Review of Sociomedical Science by Maher, Dermot P, Carr, Daniel B, Hill, Kevin, McGeeney, Brian, Weed, Valerie, Jackson, William C, DiBenedetto, David J, Moriarty, Edward M, Kulich, Ronald J

“…Abstract Objective This manuscript reviews medical literature published pertaining to the management of chronic pain with medical marijuana therapy (MMJ), with…”
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Priorities for developing countries in the global response to non-communicable diseases by Maher, Dermot, Ford, Nathan, Unwin, Nigel

“…The growing global burden of non communicable diseases (NCDs) is now killing 36 million people each year and needs urgent and comprehensive action. This…”
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Pilot randomized active-placebo-controlled trial of low-dose ketamine for the treatment of multiple sclerosis–related fatigue by Fitzgerald, Kathryn C, Morris, Bridget, Soroosh, Aurash, Balshi, Alexandra, Maher, Dermot, Kaplin, Adam, Nourbakhsh, Bardia

“…Background: Fatigue is the most common symptom of MS and has no effective pharmacotherapy. Objective: To determine the tolerability, safety, and efficacy of…”
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Evaluating results of the implementation research MOOC using Kirkpatrick’s four-level model: a cross-sectional mixed-methods study by Ross, Bella, Penkunas, Michael J, Maher, Dermot, Certain, Edith, Launois, Pascal

“…IntroductionAn implementation research (IR) massive open online course (MOOC) was developed by the Special Programme for Research and Training in Tropical…”
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International standards for tuberculosis care by Hopewell, Philip C, Pai, Madhukar, Maher, Dermot, Uplekar, Mukund, Raviglione, Mario C

“…Part of the reason for failing to bring about a more rapid reduction in tuberculosis incidence worldwide is the lack of effective involvement of all…”
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The general population cohort in rural south-western Uganda: a platform for communicable and non-communicable disease studies by ASIKI, Gershim, MURPHY, Georgina, MAHER, Dermot, YOUNG, Elizabeth H, KAMALI, Anatoli, SANDHU, Manjinder S, NAKIYINGI-MIIRO, Jessica, SEELEY, Janet, NSUBUGA, Rebecca N, KARABARINDE, Alex, WASWA, Laban, BIRARO, Sam, KASAMBA, Ivan, POMILLA, Cristina

“…The General Population Cohort (GPC) was set up in 1989 to examine trends in HIV prevalence and incidence, and their determinants in rural south-western Uganda…”
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The HIV-associated tuberculosis epidemic—when will we act? by Harries, Anthony D, Prof, Zachariah, Rony, PhD, Corbett, Elizabeth L, PhD, Lawn, Stephen D, MD, Santos-Filho, Ezio T, MSc, Chimzizi, Rhehab, MCommH, Harrington, Mark, BA, Maher, Dermot, DM, Williams, Brian G, PhD, De Cock, Kevin M, Prof

“…Summary Despite policies, strategies, and guidelines, the epidemic of HIV-associated tuberculosis continues to rage, particularly in southern Africa. We focus…”
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Chronic Opioid Therapy Modifies QST Changes After Ketamine Infusion in Chronic Pain Patients by Maher, Dermot P, Zhang, Yi, Ahmed, Shihab, Doshi, Tina, Malarick, Charlene, Stabach, Kristin, Mao, Jianren, Chen, Lucy

“…The long-term effects of opioids on sensitization processes are believed to be mediated through the N-methyl-D-aspartate receptor. Quantitative sensory testing…”
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