Search Results - "MAHAKIAN, Lisa M"

Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis by Zhang, Guodong, Panigrahy, Dipak, Mahakian, Lisa M., Yang, Jun, Liu, Jun-Yan, Lee, Kin Sing Stephen, Wettersten, Hiromi I., Ulu, Arzu, Hu, Xiaowen, Tam, Sarah, Hwang, Sung Hee, Ingham, Elizabeth S., Kieran, Mark W., Weiss, Robert H., Ferrara, Katherine W., Hammock, Bruce D.

“…Epidemiological and preclinical evidence supports that omega-3 dietary fatty acids (fish oil) reduce the risks of macular degeneration and cancers, but the…”
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Immune modulation resulting from MR-guided high intensity focused ultrasound in a model of murine breast cancer by Fite, Brett Z., Wang, James, Kare, Aris J., Ilovitsh, Asaf, Chavez, Michael, Ilovitsh, Tali, Zhang, Nisi, Chen, Weiyu, Robinson, Elise, Zhang, Hua, Kheirolomoom, Azadeh, Silvestrini, Matthew T., Ingham, Elizabeth S., Mahakian, Lisa M., Tam, Sarah M., Davis, Ryan R., Tepper, Clifford G., Borowsky, Alexander D., Ferrara, Katherine W.

“…High intensity focused ultrasound (HIFU) rapidly and non-invasively destroys tumor tissue. Here, we sought to assess the immunomodulatory effects of MR-guided…”
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Enhanced microbubble contrast agent oscillation following 250 kHz insonation by Ilovitsh, Tali, Ilovitsh, Asaf, Foiret, Josquin, Caskey, Charles F., Kusunose, Jiro, Fite, Brett Z., Zhang, Hua, Mahakian, Lisa M., Tam, Sarah, Butts-Pauly, Kim, Qin, Shengping, Ferrara, Katherine W.

“…Microbubble contrast agents are widely used in ultrasound imaging and therapy, typically with transmission center frequencies in the MHz range. Currently, an…”
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Toward Personalized Peptide-Based Cancer Nanovaccines: A Facile and Versatile Synthetic Approach by Kakwere, Hamilton, Ingham, Elizabeth S, Allen, Riley, Mahakian, Lisa M, Tam, Sarah M, Zhang, Hua, Silvestrini, Matthew T, Lewis, Jamal S, Ferrara, Katherine W

“…Personalized cancer vaccines (PCVs) are receiving attention as an avenue for cancer immunotherapy. PCVs employ immunogenic peptide epitopes capable of…”
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Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis by Zhang, Guodong, Panigrahy, Dipak, Hwang, Sung Hee, Yang, Jun, Mahakian, Lisa M., Wettersten, Hiromi I., Liu, Jun-Yan, Wang, Yanru, Ingham, Elizabeth S., Tam, Sarah, Kieran, Mark W., Weiss, Robert H., Ferrara, Katherine W., Hammock, Bruce D.

“…Prostaglandins derived from the cyclooxygenase (COX) pathway and epoxyeicosatrienoic acids (EETs) from the cytochrome P450/soluble epoxide hydrolase (sEH)…”
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Specific penetration and accumulation of a homing peptide within atherosclerotic plaques of apolipoprotein E-deficient mice by Hamzah, Juliana, Kotamraju, Venkata R, Seo, Jai W, Agemy, Lilach, Fogal, Valentina, Mahakian, Lisa M, Peters, David, Roth, Lise, Gagnon, M. Karen J, Ferrara, Katherine W, Ruoslahti, Erkki

“…The ability to selectively deliver compounds into atherosclerotic plaques would greatly benefit the detection and treatment of atherosclerotic disease. We…”
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Ultrasound Increases Nanoparticle Delivery by Reducing Intratumoral Pressure and Increasing Transport in Epithelial and Epithelial―Mesenchymal Transition Tumors by WATSON, Katherine D, LAI, Chun-Yen, CURRY, Fitz-Roy, REED, Rolf K, FERRARA, Katherine W, SHENGPING QIN, KRUSE, Dustin E, LIN, Yueh-Chen, JAI WOONG SEO, CARDIFF, Robert D, MAHAKIAN, Lisa M, BEEGLE, Julie, INGHAM, Elizabeth S

“…Acquisition of the epithelial-mesenchymal transition (EMT) tumor phenotype is associated with impaired chemotherapeutic delivery and a poor prognosis. In this…”
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Magnetic resonance imaging assessment of effective ablated volume following high intensity focused ultrasound by Fite, Brett Z, Wong, Andrew, Liu, Yu, Mahakian, Lisa M, Tam, Sarah M, Aina, Olulanu, Hubbard, Neil E, Borowsky, Alexander, Cardiff, Robert D, Dumont, Erik, Ferrara, Katherine W

“…Under magnetic resonance (MR) guidance, high intensity focused ultrasound (HIFU) is capable of precise and accurate delivery of thermal dose to tissues. Given…”
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Magnetic resonance thermometry at 7T for real-time monitoring and correction of ultrasound induced mild hyperthermia by Fite, Brett Z, Liu, Yu, Kruse, Dustin E, Caskey, Charles F, Walton, Jeffrey H, Lai, Chun-Yen, Mahakian, Lisa M, Larrat, Benoit, Dumont, Erik, Ferrara, Katherine W

“…While Magnetic Resonance Thermometry (MRT) has been extensively utilized for non-invasive temperature measurement, there is limited data on the use of high…”
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Insonation of Targeted Microbubbles Produces Regions of Reduced Blood Flow Within Tumor Vasculature by Hu, Xiaowen, Kheirolomoom, Azadeh, Mahakian, Lisa M, Beegle, Julie R, Kruse, Dustin E, Lam, Kit S, Ferrara, Katherine W

“…OBJECTIVESIn ultrasound molecular imaging, a sequence of high-pressure ultrasound pulses is frequently applied to destroy bound targeted microbubbles, to…”
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Immune‐mediated ECM depletion improves tumour perfusion and payload delivery by Yeow, Yen Ling, Kotamraju, Venkata Ramana, Wang, Xiao, Chopra, Meenu, Azme, Nasibah, Wu, Jiansha, Schoep, Tobias D, Delaney, Derek S, Feindel, Kirk, Li, Ji, Kennedy, Kelsey M, Allen, Wes M, Kennedy, Brendan F, Larma, Irma, Sampson, David D, Mahakian, Lisa M, Fite, Brett Z, Zhang, Hua, Friman, Tomas, Mann, Aman P, Aziz, Farah A, Kumarasinghe, M Priyanthi, Johansson, Mikael, Ee, Hooi C, Yeoh, George, Mou, Lingjun, Ferrara, Katherine W, Billiran, Hector, Ganss, Ruth, Ruoslahti, Erkki, Hamzah, Juliana

“…High extracellular matrix (ECM) content in solid cancers impairs tumour perfusion and thus access of imaging and therapeutic agents. We have devised a new…”
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Concurrent Visualization of Acoustic Radiation Force Displacement and Shear Wave Propagation with 7T MRI by Liu, Yu, Fite, Brett Z, Mahakian, Lisa M, Johnson, Sarah M, Larrat, Benoit, Dumont, Erik, Ferrara, Katherine W

“…Manual palpation is a common and very informative diagnostic tool based on estimation of changes in the stiffness of tissues that result from pathology. In the…”
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Accumulation, internalization and therapeutic efficacy of neuropilin-1-targeted liposomes by Paoli, Eric E., Ingham, Elizabeth S., Zhang, Hua, Mahakian, Lisa M., Fite, Brett Z., Gagnon, M. Karen, Tam, Sarah, Kheirolomoom, Azadeh, Cardiff, Robert D., Ferrara, Katherine W.

“…Advancements in liposomal drug delivery have produced long circulating and very stable drug formulations. These formulations minimize systemic exposure;…”
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Positron emission tomography imaging of the stability of Cu-64 labeled dipalmitoyl and distearoyl lipids in liposomes by Seo, Jai Woong, Qin, Shengping, Mahakian, Lisa M., Watson, Katherine D., Kheirolomoom, Azadeh, Ferrara, Katherine W.

“…Changes in lipid acyl chain length can result in desorption of lipid from the liposomal anchorage and interaction with blood components. PET studies of the…”
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Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis by Sundstrøm, Terje, Prestegarden, Lars, Azuaje, Francisco, Aasen, Synnøve Nymark, Røsland, Gro Vatne, Varughese, Jobin K, Bahador, Marzieh, Bernatz, Simon, Braun, Yannick, Harter, Patrick N, Skaftnesmo, Kai Ove, Ingham, Elizabeth S, Mahakian, Lisa M, Tam, Sarah, Tepper, Clifford G, Petersen, Kjell, Ferrara, Katherine W, Tronstad, Karl Johan, Lund-Johansen, Morten, Beschorner, Rudi, Bjerkvig, Rolf, Thorsen, Frits

“…Melanoma patients carry a high risk of developing brain metastases, and improvements in survival are still measured in weeks or months. Durable disease control…”
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An open environment CT-US fusion for tissue segmentation during interventional guidance by Caskey, Charles F, Hlawitschka, Mario, Qin, Shengping, Mahakian, Lisa M, Cardiff, Robert D, Boone, John M, Ferrara, Katherine W

“…Therapeutic ultrasound (US) can be noninvasively focused to activate drugs, ablate tumors and deliver drugs beyond the blood brain barrier. However,…”
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CD8+ T-Cell Density Imaging with 64Cu-Labeled Cys-Diabody Informs Immunotherapy Protocols by Seo, Jai Woong, Tavaré, Richard, Mahakian, Lisa M., Silvestrini, Matthew T., Tam, Sarah, Ingham, Elizabeth S., Salazar, Felix B., Borowsky, Alexander D., Wu, Anna M., Ferrara, Katherine W.

“…Purpose: Noninvasive and quantitative tracking of CD8+ T cells by PET has emerged as a potential technique to gauge response to immunotherapy. We apply an…”
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Tumor-specific delivery of gemcitabine with activatable liposomes by Tucci, Samantha T., Kheirolomoom, Azadeh, Ingham, Elizabeth S., Mahakian, Lisa M., Tam, Sarah M., Foiret, Josquin, Hubbard, Neil E., Borowsky, Alexander D., Baikoghli, Mo, Cheng, R. Holland, Ferrara, Katherine W.

“…Gemcitabine delivery to pancreatic ductal adenocarcinoma is limited by poor pharmacokinetics, dense fibrosis and hypo-vascularization. Activatable liposomes,…”
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Development of thermosensitive resiquimod-loaded liposomes for enhanced cancer immunotherapy by Zhang, Hua, Tang, Wei-Lun, Kheirolomoom, Azadeh, Fite, Brett Z., Wu, Bo, Lau, Kenneth, Baikoghli, Mo, Raie, Marina Nura, Tumbale, Spencer K., Foiret, Josquin, Ingham, Elizabeth S., Mahakian, Lisa M., Tam, Sarah M., Cheng, R. Holland, Borowsky, Alexander D., Ferrara, Katherine W.

“…Resiquimod (R848) is a toll-like receptor 7 and 8 (TLR7/8) agonist with potent antitumor and immunostimulatory activity. However, systemic delivery of R848 is…”
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(64)Cu-labeled LyP-1-dendrimer for PET-CT imaging of atherosclerotic plaque by Seo, Jai Woong, Baek, Hyounggee, Mahakian, Lisa M, Kusunose, Jiro, Hamzah, Juliana, Ruoslahti, Erkki, Ferrara, Katherine W

“…The ability to detect and quantify macrophage accumulation can provide important diagnostic and prognostic information for atherosclerotic plaque. We have…”
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