Search Results - "MAGNAN, CHRISTOPHE"

SSpro/ACCpro 5: almost perfect prediction of protein secondary structure and relative solvent accessibility using profiles, machine learning and structural similarity by Magnan, Christophe N, Baldi, Pierre

“…Accurately predicting protein secondary structure and relative solvent accessibility is important for the study of protein evolution, structure and function…”
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SSpro/ACCpro 6: almost perfect prediction of protein secondary structure and relative solvent accessibility using profiles, deep learning and structural similarity by Urban, Gregor, Magnan, Christophe N, Baldi, Pierre

“…Abstract Motivation Accurately predicting protein secondary structure and relative solvent accessibility is important for the study of protein evolution,…”
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SOLpro: accurate sequence-based prediction of protein solubility by Magnan, Christophe N., Randall, Arlo, Baldi, Pierre

“…Motivation: Protein insolubility is a major obstacle for many experimental studies. A sequence-based prediction method able to accurately predict the…”
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Defining the Independence of the Liver Circadian Clock by Koronowski, Kevin B., Kinouchi, Kenichiro, Welz, Patrick-Simon, Smith, Jacob G., Zinna, Valentina M., Shi, Jiejun, Samad, Muntaha, Chen, Siwei, Magnan, Christophe N., Kinchen, Jason M., Li, Wei, Baldi, Pierre, Benitah, Salvador Aznar, Sassone-Corsi, Paolo

“…Mammals rely on a network of circadian clocks to control daily systemic metabolism and physiology. The central pacemaker in the suprachiasmatic nucleus (SCN)…”
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VIRALpro: a tool to identify viral capsid and tail sequences by Galiez, Clovis, Magnan, Christophe N, Coste, Francois, Baldi, Pierre

“…Not only sequence data continue to outpace annotation information, but also the problem is further exacerbated when organisms are underrepresented in the…”
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Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory by Kwapis, Janine L., Alaghband, Yasaman, Kramár, Enikö A., López, Alberto J., Vogel Ciernia, Annie, White, André O., Shu, Guanhua, Rhee, Diane, Michael, Christina M., Montellier, Emilie, Liu, Yu, Magnan, Christophe N., Chen, Siwei, Sassone-Corsi, Paolo, Baldi, Pierre, Matheos, Dina P., Wood, Marcelo A.

“…Aging is accompanied by impairments in both circadian rhythmicity and long-term memory. Although it is clear that memory performance is affected by circadian…”
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High-throughput prediction of protein antigenicity using protein microarray data by Magnan, Christophe N., Zeller, Michael, Kayala, Matthew A., Vigil, Adam, Randall, Arlo, Felgner, Philip L., Baldi, Pierre

“…Motivation: Discovery of novel protective antigens is fundamental to the development of vaccines for existing and emerging pathogens. Most computational…”
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The DNA modification N6-methyl-2’-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction by Li, Xiang, Zhao, Qiongyi, Wei, Wei, Lin, Quan, Magnan, Christophe, Emami, Michael R., Wearick-Silva, Luis E., Viola, Thiago W., Marshall, Paul R., Yin, Jiayu, Madugalle, Sachithrani U., Wang, Ziqi, Nainar, Sarah, Vågbø, Cathrine Broberg, Leighton, Laura J., Zajaczkowski, Esmi L., Ke, Ke, Grassi-Oliveira, Rodrigo, Bjørås, Magnar, Baldi, Pierre F., Spitale, Robert C., Bredy, Timothy W.

“…DNA modification is known to regulate experience-dependent gene expression. However, beyond cytosine methylation and its oxidated derivatives, very little is…”
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Fasting Imparts a Switch to Alternative Daily Pathways in Liver and Muscle by Kinouchi, Kenichiro, Magnan, Christophe, Ceglia, Nicholas, Liu, Yu, Cervantes, Marlene, Pastore, Nunzia, Huynh, Tuong, Ballabio, Andrea, Baldi, Pierre, Masri, Selma, Sassone-Corsi, Paolo

“…The circadian clock operates as intrinsic time-keeping machinery to preserve homeostasis in response to the changing environment. While food is a known…”
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The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory by Vogel-Ciernia, Annie, Matheos, Dina P, Barrett, Ruth M, Kramár, Enikö A, Azzawi, Soraya, Chen, Yuncai, Magnan, Christophe N, Zeller, Michael, Sylvain, Angelina, Haettig, Jakob, Jia, Yousheng, Tran, Anthony, Dang, Richard, Post, Rebecca J, Chabrier, Meredith, Babayan, Alex H, Wu, Jiang I, Crabtree, Gerald R, Baldi, Pierre, Baram, Tallie Z, Lynch, Gary, Wood, Marcelo A

“…BAF53b is a neuron-specific component of the nucleosome remodeling complex mSWI/SNF that allows euchromatin formation and provides epigenetic regulation of…”
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GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice by Kammoun, Hélène L, Chabanon, Hervé, Hainault, Isabelle, Luquet, Serge, Magnan, Christophe, Koike, Tatsuro, Ferré, Pascal, Foufelle, Fabienne

“…Hepatic steatosis is present in insulin-resistant obese rodents and is concomitant with active lipogenesis. Hepatic lipogenesis depends on the insulin-induced…”
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Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans by Wigger, Leonore, Cruciani-Guglielmacci, Céline, Nicolas, Anthony, Denom, Jessica, Fernandez, Neïké, Fumeron, Frédéric, Marques-Vidal, Pedro, Ktorza, Alain, Kramer, Werner, Schulte, Anke, Le Stunff, Hervé, Liechti, Robin, Xenarios, Ioannis, Vollenweider, Peter, Waeber, Gérard, Uphues, Ingo, Roussel, Ronan, Magnan, Christophe, Ibberson, Mark, Thorens, Bernard

“…Plasma metabolite concentrations reflect the activity of tissue metabolic pathways and their quantitative determination may be informative about pathogenic…”
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Metabolic Sensing and the Brain: Who, What, Where, and How? by Levin, Barry E, Magnan, Christophe, Dunn-Meynell, Ambrose, Le Foll, Christelle

“…Unique subpopulations of specialized metabolic sensing neurons reside in a distributed network throughout the brain and respond to alterations in ambient…”
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Sequence Assembly of Yarrowia lipolytica Strain W29/CLIB89 Shows Transposable Element Diversity by Magnan, Christophe, Yu, James, Chang, Ivan, Jahn, Ethan, Kanomata, Yuzo, Wu, Jenny, Zeller, Michael, Oakes, Melanie, Baldi, Pierre, Sandmeyer, Suzanne

“…Yarrowia lipolytica, an oleaginous yeast, is capable of accumulating significant cellular mass in lipid making it an important source of biosustainable…”
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Dominant gut Prevotella copri in gastrectomised non-obese diabetic Goto–Kakizaki rats improves glucose homeostasis through enhanced FXR signalling by Péan, Noémie, Le Lay, Aurelie, Brial, Francois, Wasserscheid, Jessica, Rouch, Claude, Vincent, Mylène, Myridakis, Antonis, Hedjazi, Lyamine, Dumas, Marc-Emmanuel, Grundberg, Elin, Lathrop, Mark, Magnan, Christophe, Dewar, Ken, Gauguier, Dominique

“…Aims/hypothesis Drug and surgical-based therapies in type 2 diabetes are associated with altered gut microbiota architecture. Here we investigated the role of…”
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Role of hypothalamic de novo ceramides synthesis in obesity and associated metabolic disorders by Magnan, Christophe, Le Stunff, Hervé

“…Sphingolipid-mediated signalling pathways are described as important players in the normal functioning of neurons and nonneuronal cells in the central nervous…”
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Brain lipoprotein lipase as a regulator of energy balance by Cruciani-Guglielmacci, Céline, Magnan, Christophe

“…The central nervous system is an essential actor in the control of the energy balance. Indeed, many signals of nervous (vagal afferent for example) or…”
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Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity by Oshima, Masaya, Pechberty, Séverine, Bellini, Lara, Göpel, Sven O., Campana, Mélanie, Rouch, Claude, Dairou, Julien, Cosentino, Cristina, Fantuzzi, Federica, Toivonen, Sanna, Marchetti, Piero, Magnan, Christophe, Cnop, Miriam, Le Stunff, Hervé, Scharfmann, Raphaël

“…Aims/hypothesis During the onset of type 2 diabetes, excessive dietary intake of saturated NEFA and fructose lead to impaired insulin production and secretion…”
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Hypoglycemia-Activated GLUT2 Neurons of the Nucleus Tractus Solitarius Stimulate Vagal Activity and Glucagon Secretion by Lamy, Christophe M., Sanno, Hitomi, Labouèbe, Gwenaël, Picard, Alexandre, Magnan, Christophe, Chatton, Jean-Yves, Thorens, Bernard

“…Glucose-sensing neurons in the brainstem participate in the regulation of energy homeostasis but have been poorly characterized because of the lack of specific…”
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Dietary docosahexaenoic acid (DHA) downregulates liver DHA synthesis by inhibiting eicosapentaenoic acid elongation by Metherel, Adam H., Valenzuela, Rodrigo, Klievik, Brinley J., Cisbani, Giulia, Rotarescu, Ruxandra D., Gonzalez-Soto, Melissa, Cruciani-Guglielmacci, Céline, Layé, Sophie, Magnan, Christophe, Mutch, David M., Bazinet, Richard P.

“…DHA is abundant in the brain where it regulates cell survival, neurogenesis, and neuroinflammation. DHA can be obtained from the diet or synthesized from…”
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