Search Results - "MAGGI, C. A"

Intestinal epithelial barrier dysfunction in disease and possible therapeutical interventions by Catalioto, R-M, Maggi, C A, Giuliani, S

“…The intestinal epithelial monolayer constitutes a physical and functional barrier between the organism and the external environment. It regulates nutrients…”
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Knee osteoarthritis: a role for bradykinin? by Meini, S., Maggi, C. A.

“… Osteoarthritis (OA) is a painful and degenerating progressive disease of the joints which affects millions of patients worldwide. The cause of OA is largely…”
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Dexketoprofen/tramadol: randomised double-blind trial and confirmation of empirical theory of combination analgesics in acute pain by Moore, R. Andrew, Gay-Escoda, C., Figueiredo, R., Tóth-Bagi, Z., Dietrich, T., Milleri, S., Torres-Lagares, D., Hill, C. M., García-García, A., Coulthard, P., Wojtowicz, A., Matenko, D., Peñarrocha-Diago, M., Cuadripani, S., Pizà-Vallespir, B., Guerrero-Bayón, C., Bertolotti, M., Contini, M. P., Scartoni, S., Nizzardo, A., Capriati, A., Maggi, C. A.

“…Background Combination analgesics are effective in acute pain, and a theoretical framework predicts efficacy for combinations. The combination of dexketoprofen…”
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Spontaneous release of acetylcholine from autonomic nerves in the bladder by Zagorodnyuk, VP, Gregory, S, Costa, M, Brookes, SJH, Tramontana, M, Giuliani, S, Maggi, CA

“…Background and purpose:  Bladder contractility is regulated by intrinsic myogenic mechanisms interacting with autonomic nerves. In this study, we have…”
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Gender‐related differential effect of tachykinin NK2 receptor‐mediated visceral hyperalgesia in guinea pig colon by Bellucci, F, Buéno, L, Bugianesi, R, Crea, A, D'Aranno, V, Meini, S, Santicioli, P, Tramontana, M, Maggi, CA

“…Background and Purpose The tachykinin NK2 receptor antagonist ibodutant is under Phase III clinical investigation to treat female patients with irritable bowel…”
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Bradykinin and B2 receptor antagonism in rat and human articular chondrocytes by Meini, S, Cucchi, P, Catalani, C, Bellucci, F, Giuliani, S, Maggi, CA

“…BACKGROUND AND PURPOSE In osteoarthritis (OA), bradykinin (BK) is known to contribute to pain and synovitis, but not to cartilage degradation. Here, we…”
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Tachykinins as modulators of the micturition reflex in the central and peripheral nervous system by Lecci, A, Maggi, C.A

“…In the normal urinary bladder, tachykinins (TKs) are expressed in a population of bladder nociceptors that is sensitive to the excitatory and desensitizing…”
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The effects of tachykinins on inflammatory and immune cells by Maggi, Carlo Alberto

“…The aim of this article is to provide an up-dated overview of the available information on the role played by tachykinins in recruiting/regulating the function…”
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The neurokinin-2 receptor antagonist ibodutant improves overall symptoms, abdominal pain and stool pattern in female patients in a phase II study of diarrhoea-predominant IBS by Tack, J, Schumacher, K, Tonini, G, Scartoni, S, Capriati, A, Maggi, C A

“…Tachykinins have been implicated in the pathophysiology of IBS with diarrhoea (IBS-D). Our aim was to study the efficacy and safety of ibodutant, a selective…”
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Dissociation of dorsal root ganglion neurons into afferent and efferent-like neurons by HOLZER, P, MAGGI, C. A

“…Although the textbook function of dorsal root ganglion neurons is to signal information to the brain, a group of C-fibre and some A delta-fibre afferents have…”
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The tachykinin NK1 receptor. Part I: ligands and mechanisms of cellular activation by Quartara, L, Maggi, C A

“…The tachykinin NK1 receptor is widely expressed in the mammalian central and peripheral nervous system. Powerful pharmacological tools (agonists and…”
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Anti-tumour activity of tachykinin NK1 receptor antagonists on human glioma U373 MG xenograft by PALMA, C, BIGIONI, M, IRRISSUTO, C, NARDELLI, F, MAGGI, C. A, MANZINI, S

“…Astrocytes harbour functional receptors to many neurotransmitters, including substance P (SP), an undecapeptide belonging to the tachykinin family of peptide…”
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The dual nature of the tachykinin NK1 receptor by Maggi, C A, Schwartz, T W

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Antitumour effect of combination treatment with Sabarubicin (MEN 10755) and cis-platin (DDP) in human lung tumour xenograft by Bigioni, M., Benzo, A., Irrissuto, C., Lopez, G., Curatella, B., Maggi, C. A., Manzini, S., Crea, A., Caroli, S., Cubadda, F., Binaschi, M.

“…Purpose Sabarubicin (MEN 10755), a new disaccaride anthracycline, has shown greater efficacy than Doxorubicin in a large panel of preclinical models and now it…”
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Comparison of the molecular interactions of two antagonists, MEN16132 or icatibant, at the human kinin B2 receptor by Meini, S, Bellucci, F, Catalani, C, Cucchi, P, Giolitti, A, Giuliani, S, Quartara, L, Rotondaro, L, Zappitelli, S, Maggi, CA

“…BACKGROUND AND PURPOSE Icatibant is a well‐known kinin B2 receptor antagonist currently used for angiooedema attacks. MEN16132 is a non‐peptide B2 receptor…”
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Substance P activates responses correlated with tumour growth in human glioma cell lines bearing tachykinin NK1 receptors by PALMA, C, NARDELLI, F, MANZINI, S, MAGGI, C. A

“…The neuropeptide substance P (SP), by stimulating tachykinin NK1 receptors (NK1R), triggers a number of biological responses in human glioma cells which are…”
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Inhibition of tachykinin release from peripheral endings of sensory nerves by nociceptin, a novel opioid peptide by Giuliani, Sandro, Maggi, Carlo Alberto

“…The novel heptadecapeptide opioid, nociceptin, produced a concentration‐dependent (EC50 28 nM) suppression of the inotropic response of the guinea‐pig isolated…”
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Influence of tachykinin NK2 receptors on intestinal sensitivity and motility in newborn rats by Tramontana, M, Evangelista, S, Giuliani, S, Manzini, S, Robelet, S, Girod, V, Maggi, C.A

“…Abstract The effect of tachykinin neurokinin NK2 receptors activation on intestinal propulsion and colorectal sensitivity was studied in 7–15 days old newborn…”
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Neuropeptides as regulators of airway function: vasoactive intestinal peptide and the tachykinins by Maggi, C A, Giachetti, A, Dey, R D, Said, S I

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FLORENCE: a randomized, double-blind, phase III pivotal study of febuxostat versus allopurinol for the prevention of tumor lysis syndrome (TLS) in patients with hematologic malignancies at intermediate to high TLS risk by Spina, M., Nagy, Z., Ribera, J.M., Federico, M., Aurer, I., Jordan, K., Borsaru, G., Pristupa, A.S., Bosi, A., Grosicki, S., Glushko, N.L., Ristic, D., Jakucs, J., Montesinos, P., Mayer, J., Rego, E.M., Baldini, S., Scartoni, S., Capriati, A., Maggi, C.A., Simonelli, C.

“…Serum uric acid (sUA) control is of key relevance in tumor lysis syndrome (TLS) prevention as it correlates with both TLS and renal event risk. We sought to…”
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