Search Results - "MAES, Brigitte"

Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities by Oben, Bénedith, Froyen, Guy, Maclachlan, Kylee H., Leongamornlert, Daniel, Abascal, Federico, Zheng-Lin, Binbin, Yellapantula, Venkata, Derkach, Andriy, Geerdens, Ellen, Diamond, Benjamin T., Arijs, Ingrid, Maes, Brigitte, Vanhees, Kimberly, Hultcrantz, Malin, Manasanch, Elisabet E., Kazandjian, Dickran, Lesokhin, Alexander, Dogan, Ahmet, Zhang, Yanming, Mikulasova, Aneta, Walker, Brian, Morgan, Gareth, Campbell, Peter J., Landgren, Ola, Rummens, Jean-Luc, Bolli, Niccolò, Maura, Francesco

“…Multiple myeloma (MM) is consistently preceded by precursor conditions recognized clinically as monoclonal gammopathy of undetermined significance (MGUS) or…”
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Liquid Biopsy in Early-Stage Lung Cancer: Current and Future Clinical Applications by Vandekerckhove, Olivia, Cuppens, Kristof, Pat, Karin, Du Pont, Bert, Froyen, Guy, Maes, Brigitte

“…Lung cancer remains the leading cause of cancer death worldwide, with the majority of cases diagnosed in an advanced stage. Early-stage disease non-small cell…”
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Checklist for optimization and validation of real-time PCR assays by Raymaekers, Marijke, Smets, Rita, Maes, Brigitte, Cartuyvels, Reinoud

“…Real‐time polymerase chain reaction (PCR) is a frequently used technique in molecular diagnostics. To date, practical guidelines for the complete process of…”
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Emergence of the B.1.214.2 SARS-CoV-2 lineage with an Omicron-like spike insertion and a unique upper airway immune signature by Holtz, Andrew, Van Weyenbergh, Johan, Hong, Samuel L, Cuypers, Lize, O'Toole, Áine, Dudas, Gytis, Gerdol, Marco, Potter, Barney I, Ntoumi, Francine, Mapanguy, Claujens Chastel Mfoutou, Vanmechelen, Bert, Wawina-Bokalanga, Tony, Van Holm, Bram, Menezes, Soraya Maria, Soubotko, Katja, Van Pottelbergh, Gijs, Wollants, Elke, Vermeersch, Pieter, Jacob, Ann-Sophie, Maes, Brigitte, Obbels, Dagmar, Matheeussen, Veerle, Martens, Geert, Gras, Jérémie, Verhasselt, Bruno, Laffut, Wim, Vael, Carl, Goegebuer, Truus, van der Kant, Rob, Rousseau, Frederic, Schymkowitz, Joost, Serrano, Luis, Delgado, Javier, Wenseleers, Tom, Bours, Vincent, André, Emmanuel, Suchard, Marc A, Rambaut, Andrew, Dellicour, Simon, Maes, Piet, Durkin, Keith, Baele, Guy

“…We investigate the emergence, mutation profile, and dissemination of SARS-CoV-2 lineage B.1.214.2, first identified in Belgium in January 2021. This variant,…”
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Validation and Application of a Custom-Designed Targeted Next-Generation Sequencing Panel for the Diagnostic Mutational Profiling of Solid Tumors by Froyen, Guy, Broekmans, An, Hillen, Femke, Pat, Karin, Achten, Ruth, Mebis, Jeroen, Rummens, Jean-Luc, Willemse, Johan, Maes, Brigitte

“…The inevitable switch from standard molecular methods to next-generation sequencing for the molecular profiling of tumors is challenging for most diagnostic…”
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Triple Trouble: A Case of Multiple Resistance Mechanisms after First Generation EGFR-TKI in NSCLC by Ralki, Mike, Maes, Brigitte, Pat, Karin, Wynants, Jokke, Cuppens, Kristof

“…Epidermal growth factor receptor (EGFR)-targeted therapy has become standard of care in advanced stages EGFR-mutant non-small cell lung cancer. Acquired…”
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Dramatic Response to First Line Single Agent Pembrolizumab in Anaplastic Thyroid Carcinoma by Maes, Brigitte, Coolen, Johan, Segers, Kurt, Legius, Barbara, Spalart, Valérie, Decoster, Lynn

“…Anaplastic thyroid carcinoma (ATC) is a deadly disease with very limited therapeutic options. There is an urgent need for new and efficacious drugs…”
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Non-IG aberrations of FOXP1 in B-cell malignancies lead to an aberrant expression of N-truncated isoforms of FOXP1 by Rouhigharabaei, Leila, Finalet Ferreiro, Julio, Tousseyn, Thomas, van der Krogt, Jo-Anne, Put, Natalie, Haralambieva, Eugenia, Graux, Carlos, Maes, Brigitte, Vicente, Carmen, Vandenberghe, Peter, Cools, Jan, Wlodarska, Iwona

“…The transcription factor FOXP1 is implicated in the pathogenesis of B-cell lymphomas through chromosomal translocations involving either immunoglobulin heavy…”
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Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor by Cools, Jan, Wlodarska, Iwona, Somers, Riet, Mentens, Nicole, Pedeutour, Florence, Maes, Brigitte, De Wolf-Peeters, Christiane, Pauwels, Patrick, Hagemeijer, Anne, Marynen, Peter

“…ALK‐positive anaplastic large‐cell lymphoma (ALCL) has been recognized as a distinct type of lymphoma in the heterogeneous group of T/Null‐ALCL. While most of…”
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Primary Peripheral PNET/Ewing's Sarcoma of the Dura: a Clinicopathologic Entity Distinct from Central PNET by Dedeurwaerdere, Franceska, Giannini, Caterina, Sciot, Raf, Rubin, Brian P, Perilongo, Giorgio, Borghi, Laura, Ballotta, Maria Luisa, Cornips, Erwin, Demunter, Anouk, Maes, Brigitte, Dei Tos, Angelo P

“…We describe two cases of peripheral primitive neuroectodermal tumor–Ewing’s sarcoma (PNET-ES) arising intracranially in the leptomeninges. Both tumors…”
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Lymphocyte predominance Hodgkin disease is characterized by recurrent genomic imbalances by Franke, Sabine, Wlodarska, Iwona, Maes, Brigitte, Vandenberghe, Peter, Delabie, Jan, Hagemeijer, Anne, De Wolf-Peeters, Chris

“…Single-cell polymerase chain reaction (PCR) has been used as a tool to demonstrate clonality and B-cell origin of Reed-Sternberg (RS) cells in Hodgkin disease…”
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HLA-I diversity and tumor mutational burden by comprehensive next-generation sequencing as predictive biomarkers for the treatment of non-small cell lung cancer with PD-(L)1 inhibitors by Cuppens, Kristof, Baas, Paul, Geerdens, Ellen, Cruys, Bert, Froyen, Guy, Decoster, Lynn, Thomeer, Michiel, Maes, Brigitte

“…•High HLA-I diversity and high TMB, alone or in combination, is associated with favorable clinical outcomes to PD-1 inhibiting immunotherapy.•HLA-I diversity…”
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Immune checkpoint inhibition in early-stage non-small cell lung cancer by Cuppens, Kristof, Du Pont, Bert, Knegjens, Joost, Maes, Brigitte, Baas, Paul

“…•Immune checkpoint inhibition is a cornerstone of the multimodality surgical treatment of early-stage NSCLC.•Neoadjuvant immune checkpoint inhibitor and…”
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Diagnostic Validation of a Comprehensive Targeted Panel for Broad Mutational and Biomarker Analysis in Solid Tumors by Froyen, Guy, Geerdens, Ellen, Berden, Severine, Cruys, Bert, Maes, Brigitte

“…The use of targeted Next Generation Sequencing (NGS) for the diagnostic screening of somatic variants in solid tumor samples has proven its high clinical…”
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Primary Hyperparathyroidism in Multiple Endocrine Neoplasia Type IIa: Retrospective French Multicentric Study by Kraimps, Jean‐Louis, Denizot, Anne, Carnaille, Bruno, Henry, Jean‐François, Proye, Charles, Bacourt, François, Sarfati, Emile, Dupond, Jean‐Louis, Maes, Brigitte, Travagli, Jean‐Paul, Boneu, Andrée, Roger, Patrick, Houdent, Chantal, Barbier, Jacques, Modigliani, Elisabeth

“…Primary hyperparathyroidism (PHPT) in multiple endocrine neoplasia (MEN) type IIa is rare, occurring in 20% to 30% of the patients. The aim of this study was…”
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The Adenosinergic Pathway in Non-Small Cell Lung Cancer by Van Kerkhove, Olivier, Verfaillie, Saartje, Maes, Brigitte, Cuppens, Kristof

“…Immune checkpoint inhibitors (ICIs) targeting PD-(L)1 and CTLA-4 have revolutionized the systemic treatment of non-small cell lung cancer (NSCLC), achieving…”
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Novel gene fusion discovery in Spitz tumours and its relevance in diagnostics by Delsupehe, Louis, Steelandt, Thomas, Lemahieu, Julie, Volders, Pieter-Jan, Geerdens, Ellen, Berden, Severine, Daniels, Annick, Froyen, Guy, Maes, Brigitte

“…In addition to morphologic analysis, molecular diagnostic work up of Spitz tumours is often of great value for their accurate diagnosis/classification…”
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Neoadjuvant nivolumab with or without relatlimab in resectable non-small-cell lung cancer: a randomized phase 2 trial by Schuler, Martin, Cuppens, Kristof, Plönes, Till, Wiesweg, Marcel, Du Pont, Bert, Hegedus, Balazs, Köster, Johannes, Mairinger, Fabian, Darwiche, Kaid, Paschen, Annette, Maes, Brigitte, Vanbockrijck, Michel, Lähnemann, David, Zhao, Fang, Hautzel, Hubertus, Theegarten, Dirk, Hartemink, Koen, Reis, Henning, Baas, Paul, Schramm, Alexander, Aigner, Clemens

“…Antibodies targeting the immune checkpoint molecules PD-1, PD-L1 and CTLA-4, administered alone or in combination with chemotherapy, are the standard of care…”
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Cycle Threshold Probability Score for Immediate and Sensitive Detection of B.1.351 SARS-CoV-2 Lineage by De Smet, Dieter, Vanhee, Merijn, Maes, Brigitte, Swaerts, Koen, De Jaeger, Peter, Maelegheer, Karel, Van Hoecke, Frederik, Martens, Geert Antoine

“…Abstract Background Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern associated with immune escape is important to…”
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Surgical outcomes of patients with resectable non-small-cell lung cancer receiving neoadjuvant immunotherapy with nivolumab plus relatlimab or nivolumab: Findings from the prospective, randomized, multicentric phase II study NEOpredict-Lung by Aigner, Clemens, Du Pont, Bert, Hartemink, Koen, Wiesweg, Marcel, Vanbockrijck, Michel, Darwiche, Kaid, Hegedus, Balazs, Schramm, Alexander, Hautzel, Hubertus, Maes, Brigitte, Theegarten, Dirk, Schildhaus, Hans-Ulrich, Baas, Paul, Cuppens, Kristof, Schuler, Martin H., Plönes, Till

“…8500 Background: Feasibility of surgical resection for non-small-cell lung cancer (NSCLC) after preoperative immune checkpoint inhibitor therapy (PICIT) with…”
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