Search Results - "MAERTEN, P."

Adalimumab induces apoptosis of human monocytes: a comparative study with infliximab and etanercept by Shen, C., Assche, G. V., Colpaert, S., Maerten, P., Geboes, K., Rutgeerts, P., Ceuppens, J. L.

“…Summary Background : Adalimumab, a fully human monoclonal antibody to tumour necrosis factor, was recently introduced for therapy of Crohn's disease. Aim :…”
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B7 Interactions with CD28 and CTLA-4 Control Tolerance or Induction of Mucosal Inflammation in Chronic Experimental Colitis by Liu, Zhanju, Geboes, Karel, Hellings, Peter, Maerten, Philippe, Heremans, Hubertine, Vandenberghe, Peter, Boon, Louis, van Kooten, Peter, Rutgeerts, Paul, Ceuppens, Jan L

“…CD28-B7 interaction plays a critical costimulatory role in inducing T cell activation, while CTLA-4-B7 interaction provides a negative signal that is essential…”
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Involvement of interleukin 18 in Crohn's disease: evidence from in vitro analysis of human gut inflammatory cells and from experimental colitis models by MAERTEN, P., SHEN, C., COLPAERT, S., LIU, Z., BULLENS, D. A. M., VAN ASSCHE, G., PENNINCKX, F., GEBOES, K., VANHAM, G., RUTGEERTS, P., CEUPPENS, J. L.

“…SUMMARY An imbalance of immunoregulatory factors and/or cells contributes to uncontrolled mucosal T cell activation and inflammation in Crohn's disease (CD)…”
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A single dose of intravenous esomeprazole decreases gastric secretion in healthy volunteers by NICHITA, C., ABDOU, A. E.‐W., MAERTEN, P., HERRANZ, M., MOURET, N., THALMANN, C., MICHETTI, P. F., DORTA, G.

“…Summary Background  Data suggest that esomeprazole decreases gastric secretion. Aims  To assess the effect of a single i.v. esomeprazole dose on gastric…”
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Involvement of 4‐1BB (CD137)−4‐1BBligand interaction in the modulation of CD4+ T cell‐mediated inflammatory colitis by Maerten, P., Kwon, B. S., Shen, C., De Hertogh, G., Cadot, P., Bullens, D. M. A., Overbergh, L., Mathieu, C., Van Assche, G., Geboes, K., Rutgeerts, P., Ceuppens, J. L.

“…Summary 4‐1BB ligand (4‐1BBL) expressed on antigen‐presenting cells interacts with 4‐1BB on activated T cells (especially CD8+ cells) and co‐stimulates the…”
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Infliximab induces apoptosis of monocytes and T lymphocytes in a human–mouse chimeric model by Shen, Chong, Maerten, Philippe, Geboes, Karel, Van Assche, Gert, Rutgeerts, Paul, Ceuppens, Jan L.

“…Tumor necrosis factor (TNF) antagonism with monoclonal antibodies is an effective therapy for severe Crohn's disease and rheumatoid arthritis. Recent studies…”
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Effects of interleukin 4 on CD25 +CD4 + regulatory T cell function by Maerten, Philippe, Shen, Chong, Bullens, Dominique M.A., Van Assche, Gert, Van Gool, Stefaan, Geboes, Karel, Rutgeerts, Paul, Ceuppens, Jan L.

“…CD25 +CD4 + regulatory T cells (Tregs) contribute to the maintenance of peripheral tolerance against self and non-self. The modulatory effects of cytokines,…”
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Investigations for esophageal motility and reflux by Wiesel, P H, Maerten, P, Guyot, J

“…High resolution manometry represents an interesting technological advance, facilitating the procedure, a continuous recording of the peristalsis on a single…”
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Involvement of 4-1BB (CD137)-4-1BBligand interaction in the modulation of CD4^sup +^ T cell-mediated inflammatory colitis by Maerten, P, Kwon, B S, Shen, C, De Hertogh, G

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Acute gastrointestinal bleeding by Nichita, C, Maerten, P, Viani, F, Jornod, P, Dorta, G

“…Gastrointestinal bleeding is among the major clinical challenges for the gastroenterologists and the initial approach is very complex. For a big part of…”
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Inhibition of glycolipid biosynthesis by N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin protects against the inflammatory response in hapten-induced colitis by Shen, Chong, Bullens, Dominique, Kasran, Ahmad, Maerten, Philippe, Boon, Louis, Aerts, Johannes M.F.G, van Assche, Gert, Geboes, Karel, Rutgeerts, Paul, Ceuppens, Jan L

“…Since glycolipid biosynthesis is potentially involved in immunological and inflammatory responses, we tested the effect of a novel inhibitor of intracellular…”
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ORIGINAL ARTICLE: Involvement of 4-1BB (CD137)-4-1BBligand interaction in the modulation of CD4 super(+) T cell-mediated inflammatory colitis by Maerten, P, Kwon, B S, Shen, C, De Hertogh, G, Cadot, P, Bullens, DMA, Overbergh, L, Mathieu, C, Van Assche, G, Geboes, K, Rutgeerts, P, Ceuppens, J L

“…4-1BB ligand (4-1BBL) expressed on antigen-presenting cells interacts with 4-1BB on activated T cells (especially CD8 super(+) cells) and co-stimulates the…”
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Effects of interleukin 4 on CD25 super(+)CD4 super(+) regulatory T cell function by Maerten, P, Shen, C, Bullens, DMA, Van Assche, G, Van Gool, S, Geboes, K, Rutgeerts, P, Ceuppens, J L

“…CD25 super(+)CD4 super(+) regulatory T cells (Tregs) contribute to the maintenance of peripheral tolerance against self and non-self. The modulatory effects of…”
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Interleukin-12 abrogates the effector functions of regulatory T cells in an experimental colitis by LIU, Z, MAERTEN, P, COLPAERT, S, CEUPPENS, J, RUTGEERTS, P

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Functional expression of 4-1BB (CD137) in the inflammatory tissue in Crohn's disease by Maerten, Philippe, Geboes, Karel, Hertogh, Gert De, Shen, Chong, Cadot, Pascal, Bullens, Dominique M.A, Assche, Gert Van, Penninckx, Freddy, Rutgeerts, Paul, Ceuppens, Jan L

“…4-1BB ligand (L) expressed on antigen presenting cells (APC) interacts with 4-1BB, expressed on activated T cells and this interaction costimulates T cells to…”
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Differentiating role of B7-CD28/CTLA-4 interaction in the induction of mucosal inflammation and regulatory T cell functions in chronic experimental colitis by LIU, Z, GASTHUISBERG, U, MAERTEN, P, COLPAERT, S, CEUPPENS, J, GEBOES, K, RUTGEERTS, P

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In vitro evaluation of IL-18 effects in Crohn's disease by MAERTEN, P, COLPAERT, S, LIU, Z, GEBOES, K, CEUPPENS, J, RUTGEERTS, P

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Contribution of endoscopy in palliative oncology (endoprosthesis, photodynamic therapy, parenteral nutrition by Maerten, P, El Wafa Abdou, A, Kessler-Brondolo, V, Doron, M, Ortner, M A

“…The aim of this review is to give an overview of palliative endoscopic treatment options in patients with advanced cancers of the esophagus, stomach, pancreas…”
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Targeting of costimulatory molecules as a therapeutic approach in inflammatory bowel disease by Maerten, Philippe, Liu, Zhanju, Ceuppens, Jan L

“…Crohn's disease and ulcerative colitis are inflammatory bowel diseases (IBD) of unknown pathogenesis, for which no curative treatment is currently available…”
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In vitro analysis of interferon gamma (IFN-gamma) and interleukin-12 (IL-12) production and their effects in ileal Crohn's disease by Colpaert, Stefaan, Vastraelen, Kathleen, Liu, Zhanju, Maerten, Philippe, Shen, Chong, Penninckx, Freddy, Geboes, Karel, Rutgeerts, Paul, Ceuppens, Jan L

“…Crohn's disease is an inflammatory disease of the gut in which tumour necrosis factor (TNF) and T helper 1 (Th1) cytokines (interleukin (IL)-12, interferon…”
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