Search Results - "MAELICKE, Alfred"

Galantamine slows down plaque formation and behavioral decline in the 5XFAD mouse model of Alzheimer's disease by Bhattacharya, Soumee, Haertel, Christin, Maelicke, Alfred, Montag, Dirk

“…The plant alkaloid galantamine is an established symptomatic drug treatment for Alzheimer's disease (AD), providing temporary cognitive and global relief in…”
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Nasal Application of the Galantamine Pro-drug Memogain Slows Down Plaque Deposition and Ameliorates Behavior in 5X Familial Alzheimer's Disease Mice by Bhattacharya, Soumee, Maelicke, Alfred, Montag, Dirk

“…The plant alkaloid galantamine is an established symptomatic drug treatment for Alzheimer's disease (AD), providing cognitive and global relief in human…”
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Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors by Samochocki, Marek, Höffle, Anja, Fehrenbacher, Andreas, Jostock, Ruth, Ludwig, Jürgen, Christner, Claudia, Radina, Martin, Zerlin, Marion, Ullmer, Christoph, Pereira, Edna F R, Lübbert, Hermann, Albuquerque, Edson X, Maelicke, Alfred

“…Galantamine (Reminyl), an approved treatment for Alzheimer's disease (AD), is a potent allosteric potentiating ligand (APL) of human alpha 3 beta 4, alpha 4…”
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Allosteric modulation of nicotinic receptors as a treatment strategy for Alzheimer's disease by Maelicke, A

“…Impairment of the central cholinergic system has a pivotal role in the cognitive decline observed in patients with Alzheimer's disease (AD). One of the most…”
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Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease by Maelicke, Alfred, Albuquerque, Edson X

“…The basic symptoms of Alzheimer's dementia, i.e., a loss in cognitive function, are due to impaired nicotinic cholinergic neurotransmission. To compensate for…”
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Allosteric sensitization of nicotinic receptors by galantamine, a new treatment strategy for Alzheimer’s disease by Maelicke, Alfred, Samochocki, Marek, Jostock, Ruth, Fehrenbacher, Andreas, Ludwig, Jürgen, Albuquerque, Edson X, Zerlin, Marion

“…Cholinesterase inhibitors are the only approved drug treatment for patients with mild to moderately severe Alzheimer’s disease. Interestingly, the clinical…”
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Choline is a Selective Agonist of α7 Nicotinic Acetylcholine Receptors in the Rat Brain Neurons by Alkondon, Manickavasagom, Pereira, Edna F. R., Cartes, Wellington S., Maelicke, Alfred, Albuquerque, Edson X.

“…In the present study, we demonstrate that choline, a precursor of acetylcholine (ACh) and a product of acetylcholine hydrolysis by acetylcholinesterase (AChE),…”
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The nicotinic allosteric potentiating ligand galantamine facilitates synaptic transmission in the mammalian central nervous system by Santos, Máriton D, Alkondon, Manickavasagom, Pereira, Edna F R, Aracava, Yasco, Eisenberg, Howard M, Maelicke, Alfred, Albuquerque, Edson X

“…In this study, the patch-clamp technique was used to determine the effects of galantamine, a cholinesterase inhibitor and a nicotinic allosteric potentiating…”
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Allosterically potentiating ligands of nicotinic receptors as a treatment strategy for Alzheimer’s disease by Maelicke, Alfred, Schrattenholz, Andre, Samochocki, Marek, Radina, Martin, Albuquerque, Edson X

“…One of the most prominent cholinergic deficit in Alzheimer’s disease (AD) is the reduced number of nicotinic acetylcholine receptors (nAChR) in the hippocampus…”
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The Expression Level of the Orphan Nuclear Receptor GCNF (Germ Cell Nuclear Factor) Is Critical for Neuronal Differentiation by Sattler, Ulrike, Samochocki, Marek, Maelicke, Alfred, Zechel, Christina

“…The germ cell nuclear factor (GCNF) is essential for normal embryonic development and gametogenesis. To test the prediction that GCNF is additionally required…”
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Production of Ceramides Causes Apoptosis during Early Neural Differentiation in Vitro by Herget, Thomas, Esdar, Christina, Oehrlein, Silke A., Heinrich, Michael, Schütze, Stefan, Maelicke, Alfred, van Echten-Deckert, Gerhild

“…To investigate signal transduction pathways leading to apoptosis during the early phase of neurogenesis, we employed PCC7-Mz1 cells, which cease to proliferate…”
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Pharmacokinetic rationale for switching from donepezil to galantamine by Maelicke, Alfred

“…Galantamine, the most recently approved acetylcholinesterase inhibitor (AChEI) for usein the United States, has allosteric modulating activity at nicotinic…”
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Retinoic Acid Induces Apoptosis‐Associated Neural Differentiation of a Murine Teratocarcinoma Cell Line by Herget, Thomas, Specht, Heike, Esdar, Christina, Oehrlein, Silke A., Maelicke, Alfred

“…: Incubation with all‐trans retinoic acid (RA) induces PCC7‐Mz1 embryonic carcinoma cells to cease proliferation and to develop into a tissue‐like pattern of…”
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P4‐265: Memogain, a pleasant, highly potent and neuroprotective novel drug treatment in Alzheimer's disease by Maelicke, Alfred

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Memogain, a pleasant, highly potent and neuroprotective novel drug treatment in Alzheimer's disease by Maelicke, Alfred

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Galantamine-induced Amyloid-β Clearance Mediated via Stimulation of Microglial Nicotinic Acetylcholine Receptors by Takata, Kazuyuki, Kitamura, Yoshihisa, Saeki, Mana, Terada, Maki, Kagitani, Sachiko, Kitamura, Risa, Fujikawa, Yasuhiro, Maelicke, Alfred, Tomimoto, Hidekazu, Taniguchi, Takashi, Shimohama, Shun

“…Reduction of brain amyloid-β (Aβ) has been proposed as a therapeutic target for Alzheimer disease (AD), and microglial Aβ phagocytosis is noted as an Aβ…”
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P4‐022: MEMOGAIN REGULATES TAU PHOSPHORYLATION IN AN IMMUNOTOXIN MODEL OF CHOLINERGIC CELL LOSS by Van Kampen, Darren, Maelicke, Alfred, Van Kampen, Jackalina M.

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Nicotinic cholinoceptive neurons of the frontal cortex are reduced in Alzheimer's disease by Schröder, H, Giacobini, E, Struble, R G, Zilles, K, Maelicke, A

“…The cellular distribution of nicotinic acetylcholine receptors was studied in the frontal cortex (area 10) of 1) Alzheimer patients and compared to 2)…”
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Memogain; supra-bioavailable nicotinic enhancer for the treatment of Alzheimer's disease by Maelicke, Alfred

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P2‐223: Memogain; supra‐bioavailable nicotinic enhancer for the treatment of Alzheimer's disease by Maelicke, Alfred

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