Search Results - "MADWED, Jeffrey"

Novel cross-talk within the IKK family controls innate immunity by Clark, Kristopher, Peggie, Mark, Plater, Lorna, Sorcek, Ronald J, Young, Erick R R, Madwed, Jeffrey B, Hough, Joanne, McIver, Edward G, Cohen, Philip

“…Members of the IKK {IκB [inhibitor of NF-κB (nuclear factor κB)] kinase} family play a central role in innate immunity by inducing NF-κB- and IRF [IFN…”
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How Does Circadian Rhythm Impact Salt Sensitivity of Blood Pressure in Mice? A Study in Two Close C57Bl/6 Substrains by Combe, Roy, Mudgett, John, El Fertak, Lahcen, Champy, Marie-France, Ayme-Dietrich, Estelle, Petit-Demoulière, Benoit, Sorg, Tania, Herault, Yann, Madwed, Jeffrey B, Monassier, Laurent

“…Mouse transgenesis has provided the unique opportunity to investigate mechanisms underlying sodium kidney reabsorption as well as end organ damage. However,…”
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Early and transient sodium-hydrogen exchanger isoform 1 inhibition attenuates subsequent cardiac hypertrophy and heart failure following coronary artery ligation by Kilić, Ana, Huang, Cathy X, Rajapurohitam, Venkatesh, Madwed, Jeffrey B, Karmazyn, Morris

“…Na(+)/H(+) exchanger 1 (NHE-1) inhibition attenuates the hypertrophic response and heart failure in various experimental models. As the hypertrophic program is…”
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Pyrazole Urea-Based Inhibitors of p38 MAP Kinase:  From Lead Compound to Clinical Candidate by Regan, John, Breitfelder, Steffen, Cirillo, Pier, Gilmore, Thomas, Graham, Anne G, Hickey, Eugene, Klaus, Bernhard, Madwed, Jeffrey, Moriak, Monica, Moss, Neil, Pargellis, Chris, Pav, Sue, Proto, Alfred, Swinamer, Alan, Tong, Liang, Torcellini, Carol

“…We report on a series of N-pyrazole, N‘-aryl ureas and their mode of binding to p38 mitogen activated protein kinase. Importantly, a key binding domain that is…”
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Collagen‐induced arthritis is exacerbated in C‐reactive protein–deficient mice by Jones, Nicholas R., Pegues, Melissa A., McCrory, Mark A., Kerr, Steven W., Jiang, Huiping, Sellati, Rosemarie, Berger, Valentina, Villalona, Jorge, Parikh, Rajvee, McFarland, Mary, Pantages, Lynn, Madwed, Jeffrey B., Szalai, Alexander J.

“…Objective Blood C‐reactive protein (CRP) is routinely measured to gauge inflammation. In rheumatoid arthritis (RA), a heightened CRP level is predictive of a…”
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Identification of a Potent Sodium Hydrogen Exchanger Isoform 1 (NHE1) Inhibitor with a Suitable Profile for Chronic Dosing and Demonstrated Cardioprotective Effects in a Preclinical Model of Myocardial Infarction in the Rat by Huber, John D, Bentzien, Jörg, Boyer, Stephen J, Burke, Jennifer, De Lombaert, Stéphane, Eickmeier, Christian, Guo, Xin, Haist, James V, Hickey, Eugene R, Kaplita, Paul, Karmazyn, Morris, Kemper, Raymond, Kennedy, Charles A, Kirrane, Thomas, Madwed, Jeffrey B, Mainolfi, Elizabeth, Nagaraja, Nelamangara, Soleymanzadeh, Fariba, Swinamer, Alan, Eldrup, Anne B

“…Sodium–hydrogen exchanger isoform 1 (NHE1) is a ubiquitously expressed transmembrane ion channel responsible for intracellular pH regulation. During myocardial…”
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Anti-Inflammatory Effects of a p38 Mitogen-Activated Protein Kinase Inhibitor During Human Endotoxemia by Branger, Judith, van den Blink, Bernt, Weijer, Sebastiaan, Madwed, Jeffrey, Bos, Carina L, Gupta, Abhya, Yong, Chan-Loi, Polmar, Stephen H, Olszyna, Dariusz P, Hack, C. Erik, van Deventer, Sander J. H, Peppelenbosch, Maikel P, van der Poll, Tom

“…The p38 mitogen-activated protein kinase (MAPK) participates in intracellular signaling cascades resulting in inflammatory responses. Therefore, inhibition of…”
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Indole RSK inhibitors. Part 1: Discovery and initial SAR by Boyer, Stephen J., Burke, Jennifer, Guo, Xin, Kirrane, Thomas M., Snow, Roger J., Zhang, Yunlong, Sarko, Chris, Soleymanzadeh, Lida, Swinamer, Alan, Westbrook, John, DiCapua, Frank, Padyana, Anil, Cogan, Derek, Gao, Amy, Xiong, Zhaoming, Madwed, Jeffrey B., Kashem, Mohammed, Kugler, Stanley, O’Neill, Margaret M.

“…A series of inhibitors for the 90kDa ribosomal S6 kinase (RSK) based on an 1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide scaffold were…”
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p38 Mitogen-Activated Protein Kinase Inhibition Ameliorates Angiotensin II–Induced Target Organ Damage by Park, Joon-Keun, Fischer, Robert, Dechend, Ralf, Shagdarsuren, Erdenechimeg, Gapeljuk, Andrej, Wellner, Maren, Meiners, Silke, Gratze, Petra, Al-Saadi, Nidal, Feldt, Sandra, Fiebeler, Anette, Madwed, Jeffrey B, Schirdewan, Alexander, Haller, Hermann, Luft, Friedrich C, Muller, Dominik N

“…We investigated whether or not p38 mitogen-activated protein kinase inhibition ameliorates angiotensin II–induced target organ damage. We used double…”
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Mitigation of off-target adrenergic binding and effects on cardiovascular function in the discovery of novel ribosomal S6 kinase 2 inhibitors by Fryer, Ryan M, Muthukumarana, Akalushi, Chen, Rong Rhonda, Smith, James D, Mazurek, Suzanne Nodop, Harrington, Kyle E, Dinallo, Roger M, Burke, Jennifer, DiCapua, Frank M, Guo, Xin, Kirrane, Thomas M, Snow, Roger J, Zhang, Yunlong, Soleymanzadeh, Fariba, Madwed, Jeffrey B, Kashem, Mohammed A, Kugler, Stanley Z, O'Neill, Margaret M, Harrison, Paul C, Reinhart, Glenn A, Boyer, Stephen J

“…We previously reported the discovery of a novel ribosomal S6 kinase 2 (RSK2) inhibitor, (R)-5-Methyl-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]…”
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Effects of carvedilol on structural and functional outcomes and plasma biomarkers in the mouse transverse aortic constriction heart failure model by Hampton, Caryn, Rosa, Raymond, Szeto, Daphne, Forrest, Gail, Campbell, Barry, Kennan, Richard, Wang, Shubing, Huang, Chin-Hu, Gichuru, Loise, Ping, Xiaoli, Shen, Xiaolan, Small, Kersten, Madwed, Jeffrey, Lynch, Joseph J

“…Introduction: Despite the widespread use of the mouse transverse aortic constriction heart failure model, there are no reports on the characterization of the…”
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BI 5700, a Selective Chemical Inhibitor of IκB Kinase 2, Specifically Suppresses Epithelial-Mesenchymal Transition and Metastasis in Mouse Models of Tumor Progression by Huber, Margit A, Maier, Harald J, Alacakaptan, Memetcan, Wiedemann, Eva, Braunger, Jürgen, Boehmelt, Guido, Madwed, Jeffrey B, Young, Erick R R, Marshall, Daniel R, Pehamberger, Hubert, Wirth, Thomas, Kraut, Norbert, Beug, Hartmut

“…Increasing evidence suggests that processes termed epithelial-mesenchymal transitions (EMTs) play a key role in therapeutic resistance, tumor recurrence, and…”
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Discovery and Optimization of p38 Inhibitors via Computer-Assisted Drug Design by Goldberg, Daniel R, Hao, Ming-Hong, Qian, Kevin C, Swinamer, Alan D, Gao, Donghong A, Xiong, Zhaoming, Sarko, Chris, Berry, Angela, Lord, John, Magolda, Ronald L, Fadra, Tazmeen, Kroe, Rachel R, Kukulka, Alison, Madwed, Jeffrey B, Martin, Leslie, Pargellis, Christopher, Skow, Donna, Song, Jinhua J, Tan, Zhulin, Torcellini, Carol A, Zimmitti, Clare S, Yee, Nathan K, Moss, Neil

“…Integration of computational methods, X-ray crystallography, and structure−activity relationships will be disclosed, which lead to a new class of p38…”
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Heart failure drug discovery: Scarred or ready for remodeling? by Plump, Andrew, Madwed, Jeffrey

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Airway resistance and tissue elastance from input or transfer impedance in bronchoconstricted monkeys by Black, Kristin R, Suki, Bela, Madwed, Jeffrey B, Jackson, Andrew C

“…1  Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215 and 2  Department of Pharmacology, Boehringer Ingelheim…”
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Abstract 98a: A Novel Rodent Model of HFpEF: a Potential Platform for Understanding Disease Mechanisms and Evaluating New Therapies by Zhao, Huawei, Campbell, Barry R, Shen, Xiaolan, Madwed, Jeffrey B, Hoek, Maarten

“…Abstract only Heart failure with preserved ejection fraction (HFpEF) occurs in over 50% of total HF population today and is growing with no approved therapies…”
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Development of Capabilities for Simultaneous Assessment of Pulmonary and Systemic Hemodynamics in Conscious Rat to Identify Therapies with Pulmonary Selectivity by Zhao, Huawei, Shen, Xiaolan, Hong, Xuening, Small, Kersten, Madwed, Jeffrey

“…Abstract only Novel therapies for pulmonary arterial hypertension (PAH) that specifically dilate the pulmonary vasculature are desired. Our aim was to…”
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Determination of airway and tissue resistances after antigen and methacholine in nonhuman primates by Madwed, Jeffrey B, Jackson, Andrew C

“…Jeffrey B. Madwed 1 and Andrew C. Jackson 2 1  Department of Immunological Diseases, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut 06877;…”
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Anti-LFA-1 alpha reduces the dose of cyclosporin A needed to produce immunosuppression in heterotopic cardiac transplanted rats by Harrison, P C, Madwed, J B

“…Monoclonal antibodies (MAb) against cell adhesion molecules prolong the time to acute rejection of transplanted organs in animals. Postulated mechanisms of…”
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Slow Gastric Tube Infusion as an Approach for Assessment of Controlled Release in Rodents by Small, Kersten, Lieber, Gissela, Bateman, Thomas, Ormes, James, Shen, Xialoan, Madwed, Jeffrey

“…Abstract only Methods in rodents to inform on oral controlled release (CR) formulations in the drug discovery process are limited. To address this problem,…”
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