Search Results - "MADRAS, B. K"

Functional effects of dopamine transporter gene genotypes on in vivo dopamine transporter functioning: a meta-analysis by Faraone, S V, Spencer, T J, Madras, B K, Zhang-James, Y, Biederman, J

“…Much psychiatric genetic research has focused on a 40-base pair variable number of tandem repeats (VNTR) polymorphism located in the 3′-untranslated region…”
Get full text

Polymorphisms in the 3'-untranslated region of human and monkey dopamine transporter genes affect reporter gene expression by MILLER, G. M, MADRAS, B. K

“…Dopamine transporter (DAT) levels vary in normal subjects and deviate from the normal range in pathological states. We investigated mechanisms by which the DAT…”
Get full text

THC and CBD blood and brain concentrations following daily administration to adolescent primates by Withey, S.L., Bergman, J., Huestis, M.A., George, S.R., Madras, B.K.

“…•Adolescent primates dosed daily show stable THC, CBD blood levels for 4 months.•Pharmacokinetic tolerance does not develop to THC or CBD.•CBD did not modulate…”
Get full text

Anti-hyperactivity medication : methylphenidate and amphetamine by SEEMAN, P, MADRAS, B. K

“…How do 'stimulants' reduce hyperactivity in children and adults? How can drugs which raise extracellular dopamine result in psychomotor slowing of hyperactive…”
Get full text

A mu-opioid receptor single nucleotide polymorphism in rhesus monkey: association with stress response and aggression by MILLER, G. M, BENDOR, J, TIEFENBACHER, S, YANG, H, NOVAK, M. A, MADRAS, B. K

“…Variations in the human mu-opioid receptor gene have driven exploration of their biochemical, physiological and pathological relevance. We investigated the…”
Get full text

Dopamine transporter density in patients with attention deficit hyperactivity disorder by DOUGHERTY, D. D, BONAB, A. A, SPENCER, T. J, RAUCH, S. L, MADRAS, B. K, FISCHMAN, A. J

“…Dopamine transporter density was measured in vivo in six adult patients with attention deficit hyperactivity disorder. We have shown a 70% increase in…”
Get full text

Human genetics and pharmacology of neurotransmitter transporters by Lin, Z, Madras, B K

“…Biogenic amine neurotransmitters are released from nerve terminals and activate pre- and postsynaptic receptors. Released neurotransmitters are sequestered by…”
Get more information

Single nucleotide polymorphisms distinguish multiple dopamine transporter alleles in primates : implications for association with attention deficit hyperactivity disorder and other neuropsychiatric disorders by MILLER, G. M, DE LA GARZA, R. II, NOVAK, M. A, MADRAS, B. K

“…The human dopamine transporter (DAT) gene contains a variable number tandem repeat (VNTR; 40 bases/3 to >11 repeats) in the 3'-untranslated region (3'-UTR),…”
Get full text

2-Carbomethoxy-3-aryl-8-bicyclo[3.2.1]octanes:  Potent Non-Nitrogen Inhibitors of Monoamine Transporters by Meltzer, Peter C, Blundell, Paul, Yong, Yaw F, Chen, Zhengming, George, Clifford, Gonzalez, Mario D, Madras, Bertha K

“…Cocaine is a potent central nervous system stimulant with severe addiction liability. Its reinforcing and stimulant properties derive from inhibition of…”
Get full text

Effects of cocaine and related drugs in nonhuman primates. III. Self-administration by squirrel monkeys by Bergman, J, Madras, B K, Johnson, S E, Spealman, R D

“…The self-administration of cocaine was compared with that of bupropion, 1-(2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine, mazindol,…”
Get more information

Cannabinoid receptor agonist and antagonist effects on motor function in normal and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)-treated non-human primates by MESCHLER, Justin P, HOWLETT, Allyn C, MADRAS, Bertha K

“…Although cannabinoid effects on motor function have been extensively studied in rodents, the role of cannabinoids in regulating behavior in primates is…”
Get full text

Discriminative stimulus effects of cocaine in squirrel monkeys: involvement of dopamine receptor subtypes by Spealman, R D, Bergman, J, Madras, B K, Melia, K F

“…The involvement of dopamine (DA) receptor subtypes in the discriminative stimulus effects of cocaine was investigated in squirrel monkeys trained to…”
Get more information

Cocaine receptors labeled by [3H]2 beta-carbomethoxy-3 beta-(4-fluorophenyl)tropane by Madras, B K, Spealman, R D, Fahey, M A, Neumeyer, J L, Saha, J K, Milius, R A

“…The potent cocaine analog 2 beta-carbomethoxy-3 beta-(4-fluorophenyl)-tropane (CFT, also designated WIN 35,428) was tritiated and evaluated as a molecular…”
Get more information

1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) Analogues:  A Promising Class of Monoamine Uptake Inhibitors by Meltzer, Peter C, Butler, David, Deschamps, Jeffrey R, Madras, Bertha K

“…Dopamine, serotonin, and norepinephrine are essential for neurotransmission in the mammalian system. These three neurotransmitters have been the focus of…”
Get full text

Substituted 3-phenyltropane analogs of cocaine: synthesis, inhibition of binding at cocaine recognition sites, and positron emission tomography imaging by Meltzer, P. C, Liang, A. Y, Brownell, A. L, Elmaleh, D. R, Madras, B. K

“…It is now accepted that (-)-cocaine binds to specific recognition sites associated with monoamine transporters in the mammalian brain. In this study, several…”
Get full text

Response to Selveraj et al by Faraone, S V, Spencer, T J, Madras, B K, Zhang-James, Y, Biederman, J

Get full text

The Dopamine Transporter and Attention-Deficit/Hyperactivity Disorder by Madras, Bertha K., Miller, Gregory M., Fischman, Alan J.

“…The high incidence of attention-deficit/hyperactivity disorder (ADHD) and escalating use of ADHD medications present a compelling case for clarifying the…”
Get full text

Effects of cocaine and related drugs in nonhuman primates. I. [3H]cocaine binding sites in caudate-putamen by Madras, B K, Fahey, M A, Bergman, J, Canfield, D R, Spealman, R D

“…Specific binding sites for [3H]cocaine were identified in caudate-putamen membranes prepared from nonhuman primate brains (Macaca fascicularis and Saimiri…”
Get more information

Polymorphisms in the 3[variant prime]-untranslated region of human and monkey dopamine transporter genes affect reporter gene expression by Miller, G M, Madras, B K

“…Dopamine transporter (DAT) levels vary in normal subjects and deviate from the normal range in pathological states. We investigated mechanisms by which the DAT…”
Get full text

Effects of cocaine and related drugs in nonhuman primates. II. Stimulant effects on schedule-controlled behavior by Spealman, R D, Madras, B K, Bergman, J

“…The behavioral effects of cocaine were compared with those of several cocaine derivatives and structurally distinct drugs that inhibit monoamine uptake…”
Get more information