A study on synthesis and thermal, spectral and biological properties of carboxylato-Mg(II) and carboxylato-Cu(II) complexes with bioactive ligands

Synthesis, elemental (CHN), spectral (FTIR), thermogravimetry (TG), differential thermal analysis (DTA) and complexometric titration have been applied to the investigation of the thermal behavior and structure of the complexes: Mg(ac) sub(2)(mpc) sub(3).3H sub(2)O(I), Mg(Clac) sub(2)(mpc) sub(2).3H...

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Bibliographic Details
Published in:	Journal of thermal analysis and calorimetry Vol. 81; no. 1; pp. 205 - 210
Main Authors:	MOJUMDAR, S. C, MADGURAMBAL, G, SALEH, M. T
Format:	Conference Proceeding Journal Article
Language:	English
Published:	Dordrecht Springer 01-07-2005
Subjects:	Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Chemistry Coordination compounds Exact sciences and technology General aspects Inorganic chemistry and origins of life Medical sciences Pharmacology. Drug treatments Preparations and properties Elementary analysis Divalent metal Complexes IR and antimicrobial activities Ligand Differential thermal analysis Transition metal Complexes Alkaline earth metal Complexes elemental analysis Antimicrobial agent DTA Mg(II) and Cu(II) complexes TG Copper II Complexes Magnesium complex Thermal analysis Chemical synthesis
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Summary:	Synthesis, elemental (CHN), spectral (FTIR), thermogravimetry (TG), differential thermal analysis (DTA) and complexometric titration have been applied to the investigation of the thermal behavior and structure of the complexes: Mg(ac) sub(2)(mpc) sub(3).3H sub(2)O(I), Mg(Clac) sub(2)(mpc) sub(2).3H sub(2)O(II), Mg(Cl sub(2)ac) sub(2)(mpc) sub(2).3H sub(2)O(III), Mg(Cl sub(3)ac) sub(2)(mpc) sub(2).3H sub(2)O(IV) and [Cu(ac) sub(2)(mpc)] sub(2).3H sub(2)O(V) (ac=CH sub(3)COO super(-), Clac=ClCH sub(2)COO super(-), Cl sub(2)ac=Cl sub(2)CHCOO super(-), Cl sub(3)ac=Cl sub(3)CCOO super(- )and mpc=methyl-3-pyridyl carbamate). Thermal decomposition of these complexes is a multi-stage processes. The composition of the complexes and the solid state intermediate and resultant products of thermolysis had been identified by means of elemental analysis and complexometric titration. The possible scheme of decomposition of the complexes is suggested. Heating the complexes first resulted in a release of water molecules. The TG results show that the loss of the volatile ligand (mpc) occurs in one step for complexes II, IV and V, and in two steps for complexes I and III. The final solid product of thermal decomposition was MgO or CuO. The thermal stability of the complexes can be ordered in the sequence: I=II<IV<III<V. Mpc was coordinated to Mg(II) or Cu(II) through the nitrogen atom of its heterocyclic ring. IR data suggest to a unidentate coordination of carboxylates to magnesium or copper n complexes I-V. The preliminary studies have shown that the complexes do have antimicrobial activities against bacteria, yeasts and/or fungi. The highest antimicrobial activities were manifested by the complex V.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1388-6150 1588-2926 1572-8943
DOI:	10.1007/s10973-005-0768-5