Search Results - "MADGE, D. J"

Medicinal Chemistry of Neuronal Voltage-Gated Sodium Channel Blockers by Anger, Thorsten, Madge, David J, Mulla, Mushtaq, Riddall, Dieter

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Synaptic activation of metabotropic glutamate receptors in the parallel fibre-Purkinje cell pathway in rat cerebellar slices by Batchelor, A M, Madge, D J, Garthwaite, J

“…Glutamate, the major excitatory neurotransmitter in the central nervous system, acts through two broad classes of receptors: ion channel-linked (ionotropic)…”
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The effects of a novel and selective inhibitor of tryptophan 2,3-dioxygenase on tryptophan and serotonin metabolism in the rat by Salter, Mark, Hazelwood, Robert, Pogson, Christopher I., Iyer, Ramachandran, Madge, David J.

“…The effects of a novel inhibitor 680C91 (( E)-6-fluoro-3-[2-(3-pyridyl)vinyl]-1 H-indole) of the key enzyme of tryptophan catabolism tryptophan 2,3-dioxygenase…”
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The role of sodium channels in neuropathic pain by Rogers, Marc, Tang, Lam, Madge, David J., Stevens, Edward B.

“…Our knowledge of the ion channels, receptors and signalling mechanisms involved in pain pathophysiology, and which specific channels play a role in subtypes of…”
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The Effects of an inhibitor of tryptophan 2,3-dioxygenase and a combined inhibitor of tryptophan 2,3-dioxygenase and 5-HT reuptake in the rat by Salter, M., Hazelwood, R., Pogson, C.I., Iyer, R., Madge, D.J., Jones, H.T., Cooper, B.R., Cox, R.F., Wang, C.M., Wiard, R.P.

“…The effects of a novel inhibitor 680C91 (( E)-6-fluoro-3-[2-(3-pyridyl)vinyl]-1 H-indole) of the key enzyme of tryptophan catabolism tryptophan 2,3-dioxygenase…”
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Effects of 540C91 [(E)-3-[2-(4'-pyridyl)-vinyl]-1H-indole], an inhibitor of hepatic tryptophan dioxygenase, on brain quinolinic acid in mice by REINHARD, J. F, FLANAGAN, E. M, MADGE, D. J, IYER, R, SALTER, M

“…Studies were undertaken to assess the role of the liver in the formation of the neurotoxin quinolinic acid in the brain. A selective and potent inhibitor of…”
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Synthesis and Biological Evaluation of Novel Pyrazoles and Indazoles as Activators of the Nitric Oxide Receptor, Soluble Guanylate Cyclase by Selwood, David L, Brummell, David G, Budworth, Joanna, Burtin, Guillaume E, Campbell, Richard O, Chana, Surinder S, Charles, Ian G, Fernandez, Patricia A, Glen, Robert C, Goggin, Maria C, Hobbs, Adrian J, Kling, Marcel R, Liu, Qian, Madge, David J, Meillerais, Sylvie, Powell, Kenneth L, Reynolds, Karen, Spacey, Graham D, Stables, Jeremy N, Tatlock, Mark A, Wheeler, Kerry A, Wishart, Grant, Woo, Chi-Kit

“…Database searching and compound screening identified 1-benzyl-3-(3-dimethylaminopropyloxy)indazole (benzydamine, 3) as a potent activator of the nitric oxide…”
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New synthesis of (±)-α-CMBHC and its confirmation as a metabolite of α-tocopherol (vitamin E) by Pope, Simon A.S, Burtin, Guillaume E, Clayton, Peter T, Madge, David J, Muller, David P.R

“…There is currently interest in the metabolism of the various compounds which make up the vitamin E family, especially with regards to the possible use of…”
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Novel tryptophan dioxygenase inhibitors and combined tryptophan dioxygenase/5-HT reuptake inhibitors by Madge, D.J., Hazelwood, R., Iyer, R., Jones, H.T., Salter, M.

“…Tryptophan dioxygenase (TDO) is a liver enzyme that is responsible for the majority of the metabolism of tryptophan. A series of novel…”
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The effects of a selective inhibitor of tryptophan 2,3-dioxygenase and a combined inhibitor of tryptophan 2,3-dioxygenase and 5-HT reuptake on serotonergic function in the rat by Salter, M, Hazelwood, R, Pogson, C I, Iyer, R, Madge, D J, Jones, H T, Cooper, B R, Cox, R F, Wang, C M, Wiard, R P

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Substituted 4-phenyl-2-aminoimidazoles and 4-phenyl-4,5-dihydro-2-aminoimidazoles as voltage-gated sodium channel modulators by Zidar, Nace, Jakopin, Žiga, Madge, David J., Chan, Fiona, Tytgat, Jan, Peigneur, Steve, Dolenc, Marija Sollner, Tomašić, Tihomir, Ilaš, Janez, Mašič, Lucija Peterlin, Kikelj, Danijel

“…Voltage-gated sodium channels play an integral part in neurotransmission and their dysfunction is frequently a cause of various neurological disorders. On the…”
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Effects of tryptophan 2,3-dioxygenase inhibitors in the rat by Salter, M, Beams, R M, Critchley, M A, Hodson, H F, Iyer, R, Knowles, R G, Madge, D J, Pogson, C I

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Synthesis and analysis of conjugates of the major vitamin E metabolite, alpha-CEHC by Pope, Simon A S, Burtin, Guillaume E, Clayton, Peter T, Madge, David J, Muller, David P R

“…Glucuronide and sulphate conjugates of 2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman (alpha-CEHC), the major metabolite of alpha-tocopherol (vitamin…”
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A comparative study of sildenafil, NCX-911 and BAY41-2272 on the anococcygeus muscle of diabetic rats by KALSI, Jasjit S, RALPH, David J, MADGE, David J, KELL, Phil D, CELLEK, Selim

“…We compared the effects of a nitric oxide (NO)-releasing sildenafil (NCX-911), NO-independent soluble guanylate cyclase activator (BAY41-2272) and sildenafil…”
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New Synthesis of KT5823 Indolocarbazole Aglycone by J. Madge, David, E. Burtin, Guillaume, L. Selwood, David

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