Search Results - "MACPHAIL, A PATRICK"

Cohort Profile: The Themba Lethu Clinical Cohort, Johannesburg, South Africa by FOX, Matthew P, MASKEW, Mhairi, MACPHAIL, A. Patrick, LONG, Lawrence, BRENNAN, Alana T, WESTREICH, Daniel, MACLEOD, William B, MAJUBA, Pappie, SANNE, Ian M

“…The Themba Lethu Clinical Cohort was established in 2004 to allow large patient-level analyses from a single HIV treatment site to evaluate National Treatment…”
Get full text

Gender differences in mortality and CD4 count response among virally suppressed HIV-positive patients by Maskew, Mhairi, Brennan, Alana T, Westreich, Daniel, McNamara, Lynne, MacPhail, A Patrick, Fox, Matthew P

“…Treatment outcomes for antiretroviral therapy (ART) patients may vary by gender, but estimates from current evidence may be confounded by disease stage and…”
Get more information

Anemia among HIV-Infected Patients Initiating Antiretroviral Therapy in South Africa: Improvement in Hemoglobin regardless of Degree of Immunosuppression and the Initiating ART Regimen by Fox, Matthew P., MacPhail, A. Patrick, Sanne, Ian, Brennan, Alana T., Maskew, Mhairi, Takuva, Simbarashe

“…Among those with HIV, anemia is a strong risk factor for disease progression and death independent of CD4 count and viral load. Understanding the role of…”
Get full text

Poorer ART outcomes with increasing age at a large public sector HIV clinic in Johannesburg, South Africa by Maskew, Mhairi, Brennan, Alana T, MacPhail, A Patrick, Sanne, Ian M, Fox, Matthew P

“…As the current HIV-positive population ages, the absolute number of patients >50 years on treatment is increasing. We analyze the differences in treatment…”
Get full text

Dietary iron overload as a risk factor for hepatocellular carcinoma in black africans by Mandishona, Eberhard, MacPhail, A. Patrick, Gordeuk, Victor R., Kedda, Mary‐Anne, Paterson, Alan C., Rouault, Tracey A., Kew, Michael C.

“…Although the iron‐loading disease, hereditary hemochromatosis, has a strong causal association with hepatocellular carcinoma (HCC), the carcinogenic potential…”
Get full text

Kaposi Sarcoma-Associated Herpes Virus and Response to Antiretroviral Therapy: A Prospective Study of HIV-Infected Adults by Maskew, Mhairi, MacPhail, A Patrick, Whitby, Denise, Egger, Matthias, Fox, Matthew P

“…BACKGROUND:The possible impact of coinfection with the Kaposi sarcoma–associated herpes virus (KSHV) on the response to antiretroviral therapy (ART) is…”
Get full text

Ferroportin (Q248H) mutations in African families with dietary iron overload by MCNAMARA, LYNNE, GORDEUK, VICTOR R, MACPHAIL, A PATRICK

“…Background:  Dietary iron overload found in sub‐Saharan Africa might be caused by an interaction between dietary iron and an iron‐loading gene. Caucasian…”
Get full text

The feasibility of using screening criteria to reduce clinic visits for stable patients on antiretroviral therapy in South Africa by MacLeod, William B, Maskew, Mhairi, A Jaffray, Imogen, MacPhail, A Patrick, D Ive, Prudence, Fox, Matthew P

“…South African HIV care providers are exploring ways to reduce the intensity of patient visits while maintaining high quality of care. We used routinely…”
Get full text

potential role of NaFeEDTA as an iron fortificant by Bothwell, T.H, MacPhail, A.P

“…Ethylene diamine tetraacetic acid (EDTA) is a hexadentate chelator, which can combine with virtually every metal in the periodic table. CaNa2EDTA and Na2EDTA…”
Get full text

The ratio of serum transferrin receptor and serum ferritin in the diagnosis of iron status by Malope, Babatyi I., MacPhail, A. Patrick, Alberts, Marianne, Hiss, Donavon C.

“…Laboratory tests used in the diagnosis of iron status lack specificity in defining iron deficiency anaemia (IDA) and anaemia of inflammation (AI). The serum…”
Get full text

Prevalence and predictors of kaposi sarcoma herpes virus seropositivity: a cross-sectional analysis of HIV-infected adults initiating ART in Johannesburg, South Africa by Maskew, Mhairi, Macphail, A Patrick, Whitby, Denise, Egger, Matthias, Wallis, Carole L, Fox, Matthew P

“…Kaposi sarcoma (KS) is the most common AIDS-defining tumour in HIV-infected individuals in Africa. Kaposi sarcoma herpes virus (KSHV) infection precedes…”
Get full text

Evidence of Genetic Transmission in African Iron Overload by Moyo, Victor M., Mandishona, Eberhard, Hasstedt, Sandra J., Gangaidzo, Innocent T., Gomo, Zvenyika A.R., Khumalo, Hlosukwazi, Saungweme, Thokozile, Kiire, Clement F., Paterson, Alan C., Bloom, Peter, Patrick MacPhail, A., Rouault, Tracey, Gordeuk, Victor R.

“…Iron overload in Africa was previously regarded as purely due to excessive iron in traditional beer, but we recently found evidence that transferrin saturation…”
Get full text

EDTA and the absorption of iron from food by MacPhail, AP, Patel, RC, Bothwell, TH, Lamparelli, RD

“…Iron EDTA is an effective fortificant in meals of low iron bioavailability. Na2EDTA, added to food to prevent oxidation, enhances iron bioavailability by…”
Get full text

Iron deficiency and the developing world by MacPhail, A P

“…The dietary intake of iron in underdeveloped countries is based mainly on non-hem iron which is absorbed to a lesser degree that hem iron and is subjected to…”
Get full text

Basal endocrine status in African dietary iron overload by McNamara, Lynette, Panz, Vanessa R, Raal, Frederick J, Paiker, Janice, Joffe, Barry I, Gordeuk, Victor R, MacPhail, A Patrick

“…Endocrine disturbances, notably diabetes, have been well described as a complication of iron overload due to hereditary hemochromatosis and beta-thalassemia…”
Get full text

Kaposi sarcoma-associated herpesvirus and response to antiretroviral therapy: A prospective study of HIV-infected adults by Maskew, Mhairi, MacPhail, A Patrick, Whitby, Denise, Egger, Matthias, Fox, Matthew P.

Get full text

Effect of ascorbic acid administration on serum concentration of transferrin receptors by KHUMALO, H, GOMO, Z. A. R, GANGAIDZO, I. T, MOYO, V. M, MANDISHONA, E, SAUNGWEME, T, ROUAULT, T. A, GORDEUK, V. R, MACPHAIL, A. P

Get full text

Non-transferrin-bound iron and hepatic dysfunction in African dietary iron overload by Mcnamara, Lynne, Macphail, A, Mandishona, Eberhard, Bloom, Peter, Paterson, Alan, Rouault, Tracey, Gordeuk, Victor

“…Background: Circulating iron is normally bound to transferrin. Non‐transferrin‐bound iron (NTBI) has been described in most forms of iron overload, but has not…”
Get full text

Osteoporosis in african hemosiderosis: Role of alcohol and iron by Schnitzler, Christine M., Macphail, A. Patrick, Shires, Roy, Schnaid, Edward, Mesquita, Julia M., Robson, Heather J.

“…This paper aims to examine the relative contributions made by alcohol and iron overload and hypovitaminosis C to the osteoporosis associated with African…”
Get full text

Measurements of iron status and survival in African iron overload by MACPHAIL, A. P, MANDISHONA, E. M, BLOOM, P. D, PATERSON, A. C, ROUAULT, T. A, GORDEUK, V. R

“…Dietary iron overload is common in southern Africa and there is a misconception that the condition is benign. Early descriptions of the condition relied on…”
Get full text