Search Results - "MACKINNON, Alison C"

Regulation of Transforming Growth Factor-β1-driven Lung Fibrosis by Galectin-3 by MACKINNON, Alison C, GIBBONS, Michael A, SETHI, Tariq, FARNWORTH, Sarah L, LEFFLER, Hakon, NILSSON, Uif J, DELAINE, Tamara, JOHN SIMPSON, A, FORBES, Stuart J, HIRANI, Nik, GAULDIE, Jack

“…Idiopathic pulmonary fibrosis (IPF) is a chronic dysregulated response to alveolar epithelial injury with differentiation of epithelial cells and fibroblasts…”
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CD133+ Cancer Stem-like Cells in Small Cell Lung Cancer Are Highly Tumorigenic and Chemoresistant but Sensitive to a Novel Neuropeptide Antagonist by SARVI, Sana, MACKINNON, Alison C, AVLONITIS, Nicolaos, BRADLEY, Mark, RINTOUL, Robert C, RASSL, Doris M, WEI WANG, FORBES, Stuart J, GREGORY, Christopher D, SETHI, Tariq

“…Small cell lung cancer (SCLC) is a highly aggressive malignancy with poor survival rates, with initial responses nearly invariably followed by rapid recurrence…”
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Regulation of Alternative Macrophage Activation by Galectin-3 by MacKinnon, Alison C, Farnworth, Sarah L, Hodkinson, Philip S, Henderson, Neil C, Atkinson, Kirsten M, Leffler, Hakon, Nilsson, Ulf J, Haslett, Christopher, Forbes, Stuart J, Sethi, Tariq

“…Alternative macrophage activation is implicated in diverse disease pathologies such as asthma, organ fibrosis, and granulomatous diseases, but the mechanisms…”
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Galectin-3 Expression and Secretion Links Macrophages to the Promotion of Renal Fibrosis by Henderson, Neil C, Mackinnon, Alison C, Farnworth, Sarah L, Kipari, Tiina, Haslett, Christopher, Iredale, John P, Liu, Fu-Tong, Hughes, Jeremy, Sethi, Tariq

“…Macrophages have been proposed as a key cell type in the pathogenesis of renal fibrosis; however, the mechanism by which macrophages drive fibrosis is still…”
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Selective Myeloid Depletion of Galectin-3 Offers Protection Against Acute and Chronic Lung Injury by Humphries, Duncan C., Mills, Ross, Dobie, Ross, Henderson, Neil C., Sethi, Tariq, Mackinnon, Alison C.

“…Rationale: Galectin-3 (Gal-3) is an immune regulator and an important driver of fibrosis in chronic lung injury, however, its role in acute lung injury (ALI)…”
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Resistance to anti-PD-1/anti-PD-L1: galectin-3 inhibition with GB1211 reverses galectin-3-induced blockade of pembrolizumab and atezolizumab binding to PD-1/PD-L1 by Mabbitt, Joseph, Holyer, Ian D., Roper, James A., Nilsson, Ulf J., Zetterberg, Fredrik R., Vuong, Lynda, Mackinnon, Alison C., Pedersen, Anders, Slack, Robert J.

“…Background Galectin-3 (Gal-3) is a β-galactoside-binding lectin that is highly expressed within the tumor microenvironment of aggressive cancers and has been…”
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Galectin-3 Regulates Myofibroblast Activation and Hepatic Fibrosis by Henderson, Neil C., Mackinnon, Alison C., Farnworth, Sarah L., Poirier, Francoise, Russo, Francesco P., Iredale, John P., Haslett, Christopher, Simpson, Kenneth J., Sethi, Tariq

“…Central to fibrogenesis and the scarring of organs is the activation of fibroblasts into matrix-secreting myofibroblasts. We demonstrate that Galectin-3…”
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Galectin-3 inhibitor GB0139 protects against acute lung injury by inhibiting neutrophil recruitment and activation by Humphries, Duncan C., Mills, Ross, Boz, Cecilia, McHugh, Brian J., Hirani, Nikhil, Rossi, Adriano G., Pedersen, Anders, Schambye, Hans T., Slack, Robert J., Leffler, Hakon, Nilsson, Ulf J., Wang, Wei, Sethi, Tariq, Mackinnon, Alison C.

“…Rationale: Galectin-3 (Gal-3) drives fibrosis during chronic lung injury, however, its role in acute lung injury (ALI) remains unknown. Effective…”
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Galectin-3 Reduces the Severity of Pneumococcal Pneumonia by Augmenting Neutrophil Function by Farnworth, Sarah L, Henderson, Neil C, MacKinnon, Alison C, Atkinson, Kirsten M, Wilkinson, Tom, Dhaliwal, Kevin, Hayashi, Katsutoshi, Simpson, A. John, Rossi, Adriano G, Haslett, Christopher, Sethi, Tariq

“…The Gram-positive Streptococcus pneumoniae is the leading cause of community-acquired pneumonia worldwide, resulting in high mortality. Our in vivo studies…”
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Mammalian NOTCH-1 Activates β1 Integrins via the Small GTPase R-Ras by Hodkinson, Philip S., Elliott, Paul A., Lad, Yatish, McHugh, Brian J., MacKinnon, Alison C., Haslett, Christopher, Sethi, Tariq

“…Notch is a central regulator of important cell fate decisions. Notch activation produces diverse cellular effects suggesting the presence of context-dependent…”
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Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages by Kallis, Yiannis N, Scotton, Christopher J, Mackinnon, Alison C, Goldin, Robert D, Wright, Nicholas A, Iredale, John P, Chambers, Rachel C, Forbes, Stuart J

“…Liver fibrosis results from the co-ordinated actions of myofibroblasts and macrophages, a proportion of which are of bone marrow origin. The functional effect…”
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Intrapulmonary Autoantibodies to HSP72 Are Associated with Improved Outcomes in IPF by Hirani, Nik, Dransfield, Ian, Howie, Sarah, Mackinnon, Alison C., Przybylski, Alexander A., Walker, Jeremy J., Nicol, Lisa M., Mathur, Abhinav, Mills, Ross, Wallace, William A. H.

“…Rationale. Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic interstitial lung disease, with high mortality. Currently, the aetiology and the…”
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Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis by Hirani, Nikhil, MacKinnon, Alison C, Nicol, Lisa, Ford, Paul, Schambye, Hans, Pedersen, Anders, Nilsson, Ulf J, Leffler, Hakon, Sethi, Tariq, Tantawi, Susan, Gravelle, Lise, Slack, Robert J, Mills, Ross, Karmakar, Utsa, Humphries, Duncan, Zetterberg, Fredrik, Keeling, Lucy, Paul, Lyn, Molyneaux, Philip L, Li, Feng, Funston, Wendy, Forrest, Ian A, Simpson, A John, Gibbons, Michael A, Maher, Toby M

“…Galectin (Gal)-3 is a profibrotic β-galactoside-binding lectin that plays a key role in the pathogenesis of idiopathic pulmonary fibrosis (IPF) and IPF…”
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An Orally Active Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade by Vuong, Lynda, Kouverianou, Eleni, Rooney, Claire M, McHugh, Brian J, Howie, Sarah E M, Gregory, Christopher D, Forbes, Stuart J, Henderson, Neil C, Zetterberg, Fredrik R, Nilsson, Ulf J, Leffler, Hakon, Ford, Paul, Pedersen, Anders, Gravelle, Lise, Tantawi, Susan, Schambye, Hans, Sethi, Tariq, MacKinnon, Alison C

“…A combination therapy approach is required to improve tumor immune infiltration and patient response to immune checkpoint inhibitors that target negative…”
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CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure by Stutchfield, Benjamin M, Antoine, Daniel J, Mackinnon, Alison C, Gow, Deborah J, Bain, Calum C, Hawley, Catherine A, Hughes, Michael J, Francis, Benjamin, Wojtacha, Davina, Man, Tak Y, Dear, James W, Devey, Luke R, Mowat, Alan M, Pollard, Jeffrey W, Park, B. Kevin, Jenkins, Stephen J, Simpson, Kenneth J, Hume, David A, Wigmore, Stephen J, Forbes, Stuart J

“…Background & Aims Liver regeneration requires functional liver macrophages, which provide an immune barrier that is compromised after liver injury. The numbers…”
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Discovery of the Selective and Orally Available Galectin‑1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer by Zetterberg, Fredrik R., Peterson, Kristoffer, Nilsson, Ulf J., Andréasson Dahlgren, Kajsa, Diehl, Carl, Holyer, Ian, Håkansson, Maria, Khabut, Areej, Kahl-Knutson, Barbro, Leffler, Hakon, MacKinnon, Alison C., Roper, James A., Slack, Robert J., Zarrizi, Reihaneh, Pedersen, Anders

“…We have previously described a new series of selective and orally available galectin-1 inhibitors resulting in the thiazole-containing glycomimetic GB1490…”
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Cross-linking CD98 promotes integrin-like signaling and anchorage-independent growth by Rintoul, Robert C, Buttery, Robert C, Mackinnon, Alison C, Wong, Weng Sie, Mosher, Deane, Haslett, Christopher, Sethi, Tariq

“…CD98, an early marker of T-cell activation, is an important regulator of integrin-mediated adhesion events. Previous studies suggest that CD98 is coupled to…”
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Effect of GB1107, a novel galectin-3 inhibitor on pro-fibrotic signalling in the liver by MacKinnon, Alison C., Humphries, Duncan C., Herman, Kimberley, Roper, James A., Holyer, Ian, Mabbitt, Joseph, Mills, Ross, Nilsson, Ulf J., Leffler, Hakon, Pedersen, Anders, Schambye, Hans, Zetterberg, Fredrik, Slack, Robert J.

“…Galectin-3 (Gal-3) is a pro-fibrotic β-galactoside binding lectin highly expressed in fibrotic liver and implicated in hepatic fibrosis. GB1107 is a novel…”
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An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis: A Phase Ib/IIa Randomized Controlled Clinical Trial (DEFINE) by Gaughan, Erin E, Quinn, Tom M, Mills, Andrew, Bruce, Annya M, Antonelli, Jean, MacKinnon, Alison C, Aslanis, Vassilios, Li, Feng, O'Connor, Richard, Boz, Cecilia, Mills, Ross, Emanuel, Philip, Burgess, Matthew, Rinaldi, Giulia, Valanciute, Asta, Mills, Bethany, Scholefield, Emma, Hardisty, Gareth, Findlay, Emily Gwyer, Parker, Richard A, Norrie, John, Dear, James W, Akram, Ahsan R, Koch, Oliver, Templeton, Kate, Dockrell, David H, Walsh, Timothy S, Partridge, Stephen, Humphries, Duncan, Wang-Jairaj, Jie, Slack, Robert J, Schambye, Hans, Phung, De, Gravelle, Lise, Lindmark, Bertil, Shankar-Hari, Manu, Hirani, Nikhil, Sethi, Tariq, Dhaliwal, Kevin

“…High circulating galectin-3 is associated with poor outcomes in patients with coronavirus disease (COVID-19). We hypothesized that GB0139, a potent inhaled…”
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Safety and pharmacokinetics of GB1211, an oral galectin-3 inhibitor: a single- and multiple-dose first-in-human study in healthy participants by Aslanis, Vassilios, Slack, Robert J., MacKinnon, Alison C., McClinton, Catherine, Tantawi, Susan, Gravelle, Lise, Nilsson, Ulf J., Leffler, Hakon, Brooks, Ashley, Khindri, Sanjeev K., Marshall, Richard P., Pedersen, Anders, Schambye, Hans, Zetterberg, Fredrik

“…Purpose Galectin-3, a β-galactoside-binding lectin, plays a key role in several cellular pathways involved in chronic inflammation, heart disease and cancer…”
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