Search Results - "MACKIE, I. J."

A comparative evaluation of a new automated assay for von Willebrand factor activity by Lawrie, A. S., Stufano, F., Canciani, M. T., Mackie, I. J., Machin, S. J., Peyvandi, F.

“…Summary The ristocetin cofactor assay (VWF:RCo) is the reference method for assessing von Willebrand factor (VWF) activity in the diagnosis of von Willebrand's…”
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The VWF/ADAMTS13 axis in the antiphospholipid syndrome: ADAMTS13 antibodies and ADAMTS13 dysfunction by Austin, S. K., Starke, R. D., Lawrie, A. S., Cohen, H., Machin, S. J., Mackie, I. J.

“…Summary Autoantibodies to ADAMTS13 (a disintegrin‐like and metalloprotease with thrombospondin type I motif, member 13) play an important role in the…”
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Interspecific responses to distress calls in bats (Chiroptera: Vespertilionidae): a function for convergence in call design? by RUSS, J. M, JONES, G, MACKIE, I. J, RACEY, P. A

“…Distress calls were recorded from three sympatric species of pipistrelle bat (Pipistrellus nathusii, P. pipistrellus and P. pygmaeus) in England and Northern…”
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Persistent high factor VIII activity leading to increased thrombin generation – A prospective cohort study by Ryland, J.K, Lawrie, A.S, Mackie, I.J, Machin, S.J

“…Abstract Introduction A persistently elevated level of factor VIII (FVIII) is an independent risk factor for venous thromboembolism (VTE). Although the…”
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Annexin A5 polymorphism (−1C→T) and the presence of anti-annexin A5 antibodies in the antiphospholipid syndrome by de Laat, B, Derksen, R H W M, Mackie, I J, Roest, M, Schoormans, S, Woodhams, B J, de Groot, P G, van Heerde, W L

“…Background: Annexin A5 is thought to have a role in the pathophysiology of the antiphospholipid syndrome (APS)—a syndrome characterised by recurrent thrombosis…”
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Evaluation of an automated platelet-based assay of ristocetin cofactor activity by LAWRIE, A. S., MACKIE, I. J., MACHIN, S. J., PEYVANDI, F.

“…von Willebrand’s disease (VWD) is regarded as the most common congenital bleeding disorder, and although not available in all laboratories von Willebrand…”
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Postpartum aHUS Secondary to a Genetic Abnormality in Factor H Acquired Through Liver Transplantation by Brown, J. H., Tellez, J., Wilson, V., Mackie, I. J., Scully, M., Tredger, M. M., Moore, I., McDougall, N. I., Strain, L., Marchbank, K. J., Sheerin, N. S., O’Grady, J., Harris, C. L., Goodship, T. H. J.

“…We report here a young female who underwent a successful deceased donor liver transplant for hepatic vein thrombosis. Five years after transplantation she…”
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von Willebrand factor-cleaving protease activity in congenital thrombotic thrombocytopenic purpura by ALLFORD, S. L, HARRISON, P, LAWRIE, A. S, LIESNER, R, MACKIE, I. J, MACHIN, S. J

“…Thrombotic thrombocytopenic purpura (TTP) is characterized by microangiopathic haemolytic anaemia (MAHA), thrombocytopenia, fluctuating neurological…”
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Increased platelet count and leucocyte–platelet complex formation in acute symptomatic compared with asymptomatic severe carotid stenosis by McCabe, D J H, Harrison, P, Mackie, I J, Sidhu, P S, Purdy, G, Lawrie, A S, Watt, H, Machin, S J, Brown, M M

“…Objective: The risk of stroke in patients with recently symptomatic carotid stenosis is considerably higher than in patients with asymptomatic stenosis. In the…”
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Performance of the platelet function analyser PFA-100 in testing abnormalities of primary haemostasis by Harrison, P, Robinson, M S, Mackie, I J, Joseph, J, McDonald, S J, Liesner, R, Savidge, G F, Pasi, J, Machin, S J

“…The PFA-100 device is a new instrument for the in-vitro testing of platelet function. Primary haemostasis is stimulated by recording the closure time taken for…”
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A performance evaluation of commercial fibrinogen reference preparations and assays for Clauss and PT-derived fibrinogen by Mackie, J, Lawrie, A S, Kitchen, S, Gaffney, P J, Howarth, D, Lowe, G D O, Martin, J, Purdy, G, Rigsby, P, Rumley, A

“…The wide availability of fibrinogen estimations based on the prothrombin time (PT-Fg) has caused concern about the variability and clinical utility of…”
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Microparticle sizing by dynamic light scattering in fresh-frozen plasma by Lawrie, A. S., Albanyan, A., Cardigan, R. A., Mackie, I. J., Harrison, P.

“…Background   We have previously shown that fresh‐frozen plasma (FFP) contains red blood cell‐derived procoagulant microparticles (MPs) that are removable by…”
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Interactions between rivaroxaban and antiphospholipid antibodies in thrombotic antiphospholipid syndrome by Arachchillage, D. R. J., Mackie, I. J., Efthymiou, M., Isenberg, D. A., Machin, S. J., Cohen, H.

“…Summary Introduction Rivaroxaban can affect lupus anticoagulant (LA) testing and antiphospholipid antibodies (aPL) may interfere with the anticoagulant action…”
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The anticardiolipin assay is required for sensitive screening for antiphospholipid antibodies by Nash, M. J., Camilleri, R. S., Kunka, S., Mackie, I. J., Machin, S. J., Cohen, H.

“…The importance of testing for anticardiolipin antibodies (aCL) in the diagnosis of antiphospholipid syndrome (APS) in patients with thrombosis has recently…”
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Rivaroxaban limits complement activation compared with warfarin in antiphospholipid syndrome patients with venous thromboembolism by Arachchillage, D. R. J., Mackie, I. J., Efthymiou, M., Chitolie, A., Hunt, B. J., Isenberg, D. A., Khamashta, M., Machin, S. J., Cohen, H.

“…Essentials Complement activation has a pathogenic role in thrombotic antiphospholipid syndrome (APS). Coagulation proteases such as factor Xa can activate…”
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Anti‐protein C antibodies are associated with resistance to endogenous protein C activation and a severe thrombotic phenotype in antiphospholipid syndrome by Arachchillage, D. R. J., Efthymiou, M., Mackie, I. J., Lawrie, A. S., Machin, S. J., Cohen, H.

“…Summary Background Antiphospholipid antibodies may interfere with the anticoagulant activity of activated protein C (APC) to induce acquired APC resistance…”
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The sensitivity and specificity of commercial reagents for the detection of lupus anticoagulant show marked differences in performance between photo-optical and mechanical coagulometers by Lawrie, A S, Mackie, I J, Purdy, G, Machin, S J

“…This study was undertaken to appraise the application of those reagents most widely used in the UK for the detection and confirmation of lupus anticoagulant…”
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Rituximab pharmacokinetics during the management of acute idiopathic thrombotic thrombocytopenic purpura by MCDONALD, V., MANNS, K., MACKIE, I. J., MACHIN, S. J., SCULLY, M. A.

“…Background: Increasingly, patients with acute, idiopathic, antibody mediated thrombotic thrombocytopenic purpura (TTP) are being treated with rituximab to…”
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Reduced factor XII levels in patients with the antiphospholipid syndrome are associated with antibodies to factor XII by Jones, D. W., Gallimore, M. J., Mackie, I. J., Harris, S. L., Winter, M.

“…Antibodies to factor XII (FXII) have previously been identified in some patients who were lupus anti‐coagulant‐positive. The relationship between these…”
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A phenotype–genotype correlation of ADAMTS13 mutations in congenital thrombotic thrombocytopenic purpura patients treated in the United Kingdom by CAMILLERI, R. S., SCULLY, M., THOMAS, M., MACKIE, I. J., LIESNER, R., CHEN, W. J., MANNS, K., MACHIN, S. J.

“…Background:  ADAMTS13 mutations play a role in thrombotic thrombocytopenic purpura (TTP) pathogenesis. Objectives:  To establish a phenotype–genotype…”
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