Search Results - "MACKIE, Claire E"

Prediction of Human Pharmacokinetics Using Physiologically Based Modeling: A Retrospective Analysis of 26 Clinically Tested Drugs by DE BUCK, Stefan S, SINHA, Vikash K, FENU, Luca A, NIJSEN, Marjoleen J, MACKIE, Claire E, GILISSEN, Ron A. H. J

“…The aim of this study was to evaluate different physiologically based modeling strategies for the prediction of human pharmacokinetics. Plasma profiles after…”
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The Prediction of Drug Metabolism, Tissue Distribution, and Bioavailability of 50 Structurally Diverse Compounds in Rat Using Mechanism-Based Absorption, Distribution, and Metabolism Prediction Tools by DE BUCK, Stefan S, SINHA, Vikash K, FENU, Luca A, GILISSEN, Ron A, MACKIE, Claire E, NIJSEN, Marjoleen J

“…The aim of this study was to assess a physiologically based modeling approach for predicting drug metabolism, tissue distribution, and bioavailability in rat…”
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Physiologically based approaches towards the prediction of pharmacokinetics: in vitro-in vivo extrapolation by De Buck, Stefan S, Mackie, Claire E

“…In adapting to the challenge to make more informed selection of compounds for development, the pharmaceutical industry is increasingly embracing the…”
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Predicting Oral Clearance in Humans: How Close Can We Get with Allometry? by Sinha, Vikash K., De Buck, Stefan S., Fenu, Luca A., Smit, Johan W., Nijsen, Marjoleen, Gilissen, Ron A. H. J., Van Peer, Achiel, Lavrijsen, Karel, Mackie, Claire E.

“…Background Oral clearance (CL/F) is an important pharmacokinetic parameter and plays an important role in the selection of a safe and tolerable dose for…”
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Towards a Better Prediction of Peak Concentration, Volume of Distribution and Half-Life after Oral Drug Administration in Man, Using Allometry by Sinha, Vikash K., Vaarties, Karin, De Buck, Stefan S., Fenu, Luca. A., Nijsen, Marjoleen, Gilissen, Ron A. H. J., Sanderson, Wendy, Uytsel, Kelly Van, Hoeben, Eva, Peer, Achiel Van, Mackie, Claire E., Smit, Johan W.

“…Background: It is imperative that new drugs demonstrate adequate pharmacokinetic properties, allowing an optimal safety margin and convenient dosing regimens…”
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Cardio-vascular safety beyond hERG: in silico modelling of a guinea pig right atrium assay by Fenu, Luca A., Teisman, Ard, De Buck, Stefan S., Sinha, Vikash K., Gilissen, Ron A. H. J., Nijsen, Marjoleen J. M. A., Mackie, Claire E., Sanderson, Wendy E.

“…As chemists can easily produce large numbers of new potential drug candidates, there is growing demand for high capacity models that can help in driving the…”
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