A Sex-Specific Association between a 15q25 Variant and Upper Aerodigestive Tract Cancers

Sequence variants located at 15q25 have been associated with lung cancer and propensity to smoke. We recently reported an association between rs16969968 and risk of upper aerodigestive tract (UADT) cancers (oral cavity, oropharynx, hypopharynx, larynx, and esophagus) in women (OR = 1.24, P = 0.003)...

Full description

Saved in:

Bibliographic Details
Published in:	Cancer epidemiology, biomarkers & prevention Vol. 20; no. 4; pp. 658 - 664
Main Authors:	DAN CHEN, TRUONG, Therese, BUCH, Shama, NUKUI, Tomoko, FRANCESCHI, Silvia, HERRERO, Rolando, TALAMINI, Renato, KELSEY, Karl T, CHRISTENSEN, Brock, MCCLEAN, Michael D, LACKO, Martin, MANNI, Johannes J, GABORIEAU, Valerie, PETERS, Wilbert H. M, LUBINSKI, Jan, TRUBICKA, Joanna, LENER, Marcin, MUSCAT, Joshua E, LAZARUS, Philip, QINGYI WEI, STURGIS, Erich M, ZHANG, Zuo-Feng, CHANG, Shen-Chih, BYRNES, Graham, RENYI WANG, SCHWARTZ, Stephen M, CHU CHEN, BENHAMOU, Simone, LAGIOU, Pagona, HOLCATOVA, Ivana, RICHIARDI, Lorenzo, KJAERHEIM, Kristina, AGUDO, Antonio, CASTELLSAGUE, Xavier, CHABRIER, Amelie, MACFARLANE, TatianaV, BARZAN, Luigi, CANOVA, Cristina, THAKKER, Nalin S, CONWAY, David I, ZNAOR, Ariana, HEALY, Claire M, AHRENS, Wolfgang, ZARIDZE, David, SZESZENIA-DABROWSKA, Neonila, CHUANG, Shu-Chun, LISSOWSKA, Jolanta, FABIANOVA, Eleonora, BUCUR, Alexandru, BENCKO, Vladimir, FORETOVA, Lenka, JANOUT, Vladimir, CURADO, Maria Paula, KOIFMAN, Sergio, MENEZES, Ana, WUNSCH-FILHO, Victor, OLSHAN, Andrew F, WEISSLER, Mark C, JINGCHUN LUO, ROMKES, Marjorie
Format:	Journal Article
Language:	English
Published:	Philadelphia, PA American Association for Cancer Research 01-04-2011
Subjects:	Aged Aged, 80 and over Americas - epidemiology Biological and medical sciences Case-Control Studies Chromosomes, Human, Pair 15 Europe - epidemiology Female Genotype Head and Neck Neoplasms - epidemiology Head and Neck Neoplasms - genetics Humans Male Medical sciences Middle Aged Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Sex Factors Smoking - epidemiology Smoking - genetics Tumors Americas Europe Human Genetic variability Upper aerodigestive tract Sex Genotype Malignant tumor Case control study Epidemiology Cancerology Chromosome D15 Risk factor Cytogenetics Genetics ENT disease Head and neck cancer Public health Cancer
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Sequence variants located at 15q25 have been associated with lung cancer and propensity to smoke. We recently reported an association between rs16969968 and risk of upper aerodigestive tract (UADT) cancers (oral cavity, oropharynx, hypopharynx, larynx, and esophagus) in women (OR = 1.24, P = 0.003) with little effect in men (OR = 1.04, P = 0.35). In a coordinated genotyping study within the International Head and Neck Cancer Epidemiology (INHANCE) consortium, we have sought to replicate these findings in an additional 4,604 cases and 6,239 controls from 10 independent UADT cancer case-control studies. rs16969968 was again associated with UADT cancers in women (OR = 1.21, 95% CI = 1.08-1.36, P = 0.001) and a similar lack of observed effect in men [OR = 1.02, 95% CI = 0.95-1.09, P = 0.66; P-heterogeneity (P(het)) = 0.01]. In a pooled analysis of the original and current studies, totaling 8,572 UADT cancer cases and 11,558 controls, the association was observed among females (OR = 1.22, 95% CI = 1.12-1.34, P = 7 × 10(-6)) but not males (OR = 1.02, 95% CI = 0.97-1.08, P = 0.35; P(het) = 6 × 10(-4)). There was little evidence for a sex difference in the association between this variant and cigarettes smoked per day, with male and female rs16969968 variant carriers smoking approximately the same amount more in the 11,991 ever smokers in the pooled analysis of the 14 studies (P(het) = 0.86). This study has confirmed a sex difference in the association between the 15q25 variant rs16969968 and UADT cancers. Further research is warranted to elucidate the mechanisms underlying these observations.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	1055-9965 1538-7755
DOI:	10.1158/1055-9965.EPI-10-1008