Search Results - "MACFARLANE, D. E."

Recombinant B‐domain‐deleted porcine sequence factor VIII (r‐pFVIII) for the treatment of bleeding in patients with congenital haemophilia A and inhibitors by Mahlangu, J. N., Andreeva, T. A., Macfarlane, D. E., Walsh, C., Key, N. S.

“…Introduction Development of inhibitors to human FVIII (hFVIII) significantly complicates the control of bleeding events in patients with haemophilia A. Aim…”
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Activation of beta-isozyme of protein kinase C (PKC beta) is necessary and sufficient for phorbol ester-induced differentiation of HL-60 promyelocytes. Studies with PKC beta-defective PET mutant by MACFARLANE, D. E, MANZEL, L

“…12-O-Tetradecanoylphorbol-13-acetate (TPA) induces growth arrest and differentiation of a number of leukemia cell lines including HL-60 human promyelocytic…”
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Pharmacokinetics and safety of OBI-1, a recombinant B domain-deleted porcine factor VIII, in subjects with haemophilia A by KEMPTON, C. L., ABSHIRE, T. C., DEVERAS, R. A., HOOTS, W. K., GILL, J. C., KESSLER, C. M., KEY, N. S., KONKLE, B. A., KURIAKOSE, P., MACFARLANE, D. E., BERGMAN, G.

“…OBI‐1 is a recombinant B‐domain deleted porcine factor VIII (FVIII). FVIII treatment in those with haemophilia A may be complicated by the development of…”
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Unmethylated CpG‐containing oligodeoxynucleotides inhibit apoptosis in WEHI 231 B lymphocytes induced by several agents: evidence for blockade of apoptosis at a distal signalling step by MACFARLANE, D. E., MANZEL, L., KRIEG, A. M.

“…Certain oligodeoxynucleotides (ODN) containing cytosine followed by guanosine (CpG) protect B cells from apoptosis, and induce B‐cell proliferation and…”
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Isolating RNA from whole blood - the dawn of RNA-based diagnosis? by Macfarlane, Donald E, Dahle, Christopher E

“…A novel cationic surfactant solution is used to lyse blood cells and precipitate RNA and DNA. The RNA is recovered by extracting the pellet with a small volume…”
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Structure-activity relationship analysis of substituted 4-quinolinamines, antagonists of immunostimulatory CpG-oligodeoxynucleotides by Strekowski, Lucjan, Zegrocka, Oliwia, Henary, Maged, Say, Martial, Mokrosz, Maria J., Kotecka, Barbara M., Manzel, Lori, Macfarlane, Donald E.

“…On the basis of a systematic SAR analysis of substituted quinolines, a derivative 32 was synthesized that shows half-maximal inhibition of the…”
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Antagonism of Immunostimulatory CpG-Oligodeoxynucleotides by Quinacrine, Chloroquine, and Structurally Related Compounds by Macfarlane, Donald E, Manzel, Lori

“…Phosphorothioate oligodeoxynucleotides containing CpG (CpG-ODN) activate immune responses. We report that quinacrine, chloroquine, and structurally related…”
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Two dimensional benzyldimethyl-n-hexadecylammonium chloride----sodium dodecyl sulfate preparative polyacrylamide gel electrophoresis: a high capacity high resolution technique for the purification of proteins from complex mixtures by Macfarlane, D E

“…A two dimensional preparative polyacrylamide gel electrophoresis system is described which has both high resolving power and high loading capacity…”
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Inhibitors of cyclic nucleotide phosphodiesterases inhibit protein carboxyl methylation in intact blood platelets by Macfarlane, D E

“…The cycle of protein-carboxyl methylation and demethylation was studied in intact blood platelets. Platelets rapidly incorporated L-[methyl-3H]methionine and…”
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CpG-oligodeoxynucleotide-resistant variant of WEHI 231 cells by Manzel, Lori, Macfarlane, Donald E.

“…Bacterial DNA and synthetic single‐stranded oligonucleotides having unmethylated CpG motifs (CpG‐ODN) powerfully stimulate cellular immune responses by an…”
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Isolation of RNA from cells in culture using Catrimox-14 cationic surfactant by Dahle, C E, Macfarlane, D E

“…Traditional RNA isolation methods use chaotropic agents and anionic detergents to lyse cells and solubilize nucleic acids. In contrast, the cationic…”
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Direct detection of hepatitis C virus (HCV) RNA from whole blood, and comparison with HCV RNA in plasma and peripheral blood mononuclear cells by Schmidt, W N, Klinzman, D, LaBrecque, D R, Macfarlane, D E, Stapleton, J T

“…Hepatitis C virus (HCV) requires reverse transcriptase-polymerase chain reaction (RT-PCR) or branched DNA signal amplification assays to be detected in patient…”
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Phorbol diester-induced phosphorylation of nuclear matrix proteins in HL60 promyelocytes: possible role in differentiation studied by cationic detergent gel electrophoresis systems by MACFARLANE, D. E

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Neonatal group B streptococcal septicaemia in a developing country by Macfarlane, D E

“…During a 3-year study at the neonatal intensive care unit, University Hospital of the West Indies, the incidence of group B streptococcal (GBS) septicaemia was…”
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Prevention and treatment of catheter-associated urinary tract infections by Macfarlane, D E

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A phorbol ester tolerant (PET) variant of HL-60 promyelocytes by Macfarlane, D E, Gailani, D, Vann, K

“…The promyelocytic leukaemia cell line HL-60 differentiates to a macrophage-like cell when exposed to the phorbol ester 12-O-tetradecanoylphorbol 13-acetate…”
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Up-regulation of p21WAF1 expression in myeloid cells is activated by the protein kinase C pathway by Schwaller, J, Peters, U R, Pabst, T, Niklaus, G, Macfarlane, D E, Fey, M F, Tobler, A

“…Phorbol-12-myristate-13-acetate (PMA) induces p21WAF-1 expression in human myeloid leukaemic HL-60 cells. We show that this induction is specifically mediated…”
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2-Methylthioadenosine[beta-32P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets by Macfarlane, D E, Srivastava, P C, Mills, D C

“…2-Methylthio-ADP and its radioactive analogue [beta-32P]2-methylthio-ADP were synthesized and used to investigate platelet receptors for ADP. 2-Methylthio-ADP…”
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Haemophilus influenzae and genital tract infections in children by Macfarlane, D E, Sharma, D P

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The effects of methyl mercury on platelets: induction of aggregation and release via activation of the prostaglandin synthesis pathway by Macfarlane, D E

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