Search Results - "MACEWEN, E. Gregory"

Systemic Administration of an Attenuated, Tumor-Targeting Salmonella typhimurium to Dogs with Spontaneous Neoplasia: Phase I Evaluation by THAMM, Douglas H, KURZMAN, Ilene D, KING, Ivan, ZUJIN LI, SZNOL, Mario, DUBIELZIG, Richard R, VAIL, David M, MACEWEN, E. Gregory

“…Purpose: Genetically modified bacteria are a potentially powerful anticancer therapy due to their tumor targeting capacity, inherent antitumor activity, and…”
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IGF-1 receptor contributes to the malignant phenotype in human and canine osteosarcoma by MacEwen, E. Gregory, Pastor, Josep, Kutzke, Jonathan, Tsan, Rachel, Kurzman, Ilene D., Thamm, Douglas H., Wilson, Mike, Radinsky, Robert

“…To further define the role of insulin‐like growth factor‐1 (IGF‐1) and its receptor (IGF‐1R) in osteosarcoma (OS), human OS cell lines with low (SAOS‐2) and…”
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Cisplatin and Doxorubicin Combination Chemotherapy for the Treatment of Canine Osteosarcoma: A Pilot Study by Chun, Ruthanne, Kurzman, Ilene D., Couto, C. Guillermo, Klausner, Jeff, Henry, Carolyn, MacEwen, E. Gregory

“…Sixteen dogs with histologically confirmed appendicular osteosarcoma were treated by amputation followed by cisplatin and doxorubicin chemotherapy. All dogs…”
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Spontaneously Occurring Tumors of Companion Animals as Models for Human Cancer by Vail, David M., Macewen, E. Gregory

“…Spontaneous tumors in companion animals (dog and cat) offer a unique opportunity as models for human cancer biology and translational cancer therapeutics. The…”
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Preclinical study of dolastatin-10 in dogs with spontaneous neoplasia by THAMM, Douglas H, MACEWEN, E. Gregory, PHILLIPS, Brenda S, HERSHEY, A. Elizabeth, BURGESS, Kristine M, PETTIT, George R, VAIL, David M

“…To evaluate the short-term adverse effects of administration of dolastatin-10 (Dol-10) to dogs with spontaneously occurring malignant tumors. A total of 34…”
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Biological and molecular characterization of a canine hemangiosarcoma-derived cell line by Thamm, Douglas H., Dickerson, Erin B., Akhtar, Nasim, Lewis, Rachel, Auerbach, Robert, Helfand, Stuart C., MacEwen, E. Gregory

“…Canine hemangiosarcoma (HSA) is a devastating disease. Investigation of novel therapies has been limited by the limited availability of canine HSA-derived cell…”
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Spontaneous tumors in dogs and cats: models for the study of cancer biology and treatment by MACEWEN, E. G

“…Spontaneous tumors in dogs and cats are appropriate and valid model tumor systems available for testing cancer therapeutic agents or studying cancer biology…”
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Adjuvant Therapy for Melanoma in Dogs: Results of Randomized Clinical Trials Using Surgery, Liposome-encapsulated Muramyl Tripeptide, and Granulocyte Macrophage Colony-stimulating Factor by MACEWEN, E. G, KURZMAN, I. D, ROSENTHAL, R. C, FOX, L. E, ROSENBERG, M, HENRY, C, FIDEL, J, VAIL, D. M, DUBIELZIG, R. R, EVERLITH, K, MADEWELL, B. R, RODRIGUEZ, C. O, PHILLIPS, B, ZWAHLEN, C. H, OBRADOVICH, J

“…Spontaneous canine oral melanoma (COM) is a highly metastatic cancer, resistant to chemotherapy, and can serve as a model for cancer immunotherapy…”
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c-Met tyrosine kinase receptor expression and function in human and canine osteosarcoma cells by MacEwen, E Gregory, Kutzke, Jon, Carew, Jennifer, Pastor, Josep, Schmidt, Julie A, Tsan, Rachel, Thamm, Douglas H, Radinsky, Robert

“…To further characterize the role of hepatocyte growth factor-scatter factor (HGF-SF) and its receptor (c-Met) in osteosarcoma (OS), human OS cell lines with…”
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Amputation and Carboplatin for Treatment of Dogs With Osteosarcoma: 48 Cases (1991 to 1993) by Bergman, Philip J., MacEwen, E. Gregory, Kurzman, Ilene D., Henry, Carolyn J., Hammer, Alan S., Knapp, Deborah W., Hale, Ann, Kruth, Stephen A., Klein, Mary K., Klausner, Jeffrey, Norris, Alan M., McCaw, Dudley, Straw, Rodney C., Withrow, Stephen J.

“…Forty‐eight dogs with histologically confirmed appendicular osteosarcoma (OSA) entered a prospective clinical trial evaluating treatment with amputation and up…”
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Prognostic factors for treatment of malignant lymphoma in dogs by Teske, E, van Heerde, P, Rutteman, G R, Kurzman, I D, Moore, P F, MacEwen, E G

“…Pretreatment characteristics of 138 dogs with malignant lymphoma were analyzed to determine prognostic factors associated with outcome (ie, complete response…”
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Intralesional lipid-complexed cytokine/superantigen immunogene therapy for spontaneous canine tumors by THAMM, Douglas H, KURZMAN, Ilene D, MACEWEN, E. Gregory, FEINMEHL, Rhonda, TOWELL, Todd L, LONGHOFER, Susan L, JOHNSON, Christine M, GEOLY, Frank J, STINCHCOMB, Dan T

“…These studies sought to determine the gene expression and short-term effects of intralesional lipid-complexed immunogene therapy with constructs encoding…”
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Evaluation of prognostic factors and sequential combination chemotherapy with doxorubicin for canine lymphoma by Keller, E.T, MacEwen, E.G, Rosenthal, R.C, Helfand, S.C, Fox, L.E

“…Fifty‐five dogs with lymphoma were treated using a doxorubicin‐based sequential combination chemotherapy protocol. Complete response, partial response, and no…”
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AN ACCELERATED TECHNIQUE FOR IRRADIATION OF MALIGNANT CANINE NASAL AND PARANASAL SINUS TUMORS by Adams, William M., Miller, Paul E., Vail, David M., Forrest, Lisa J., MacEwen, E. Gregory

“…Tumor and normal tissue response was assessed in 21 dogs with malignant nasal tumors given 42 Gy cobalt radiation in 9 or 10 fractions over 11 to 13 days…”
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Therapy for osteosarcoma in dogs with intravenous injection of liposome-encapsulated muramyl tripeptide by MacEwen, E G, Kurzman, I D, Rosenthal, R C, Smith, B W, Manley, P A, Roush, J K, Howard, P E

“…Canine osteosarcoma is a spontaneous malignancy in dogs, characterized by micrometastasis to pulmonary and extrapulmonary tissues at the time of diagnosis…”
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The immunotherapeutic potential of activated canine alveolar macrophages and antitumor monoclonal antibodies in metastatic canine melanoma by Soergel, S A, MacEwen, E G, Vail, D M, Potter, D M, Sondel, P M, Helfand, S C

“…A variety of immune cell activators can enhance the cytotoxic effects of monocytes/macrophages including interferon-gamma (IFN-gamma) and muramyl peptides,…”
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Peripheral neuroblastoma in a dog by Forrest, L.J, Galbreath, E.J, Dubielzig, R.R, MacEwen, E.G

“…Primitive neuroectodermal tumors are composed of primitive neuroepithelial cells and include tumors of the central and peripheral nervous system…”
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Evaluation of L-asparaginase:polyethylene glycol conjugate versus native L-asparaginase combined with chemotherapy: a randomized double-blind study in canine lymphoma by MacEwen, E.G. (University of Wisconsin, Madison, WI), Rosenthal, R.C, Fox, L.E, Loar, A.S, Kurzman, I.D

“…L‐asparaginase is an enzyme that inhibits protein synthesis by the depletion of sources of L‐asparagine, which is necessary for transformed lymphoid cells to…”
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Response to liposome-encapsulated doxorubicin (TLC D-99) in a dog with myeloma by Kisseberth, W.C. (University of Wisconsin, Madison, WI.), MacEwen, E.G, Helfand, S.C, Vail, D.M, London, C.L, Keller, E

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Canine oral melanoma: comparison of surgery versus surgery plus Corynebacterium parvum by MacEwen, E G, Patnaik, A K, Harvey, H J, Hayes, A A, Matus, R

“…Eighty-nine dogs with malignant oral melanoma were selected for study. All dogs were clinically staged and treated with either surgical excision alone or…”
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