Search Results - "MACDONALD, S J"

Emerging therapeutic opportunities for integrin inhibitors by Slack, R. J., Macdonald, S. J. F., Roper, J. A., Jenkins, R. G., Hatley, R. J. D.

“…Integrins are cell adhesion and signalling proteins crucial to a wide range of biological functions. Effective marketed treatments have successfully targeted…”
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Cold shock and fish by Donaldson, M. R., Cooke, S. J., Patterson, D. A., Macdonald, J. S.

“…Rapid decreases in water temperature may result in a number of physiological, behavioural and fitness consequences for fishes termed ‘cold shock’. Cold‐shock…”
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‘Loneliness in the city’: examining socio-economics, loneliness and poor health in the North East of England by Macdonald, S.J., Nixon, J., Deacon, L.

“…The aim of this study was to discover whether lower socio-economic status is associated with increased experiences of loneliness and isolation. The research…”
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Genetic and metabolic determinants of nutritional phenotype in an insect-bacterial symbiosis by MACDONALD, S. J., THOMAS, G. H., DOUGLAS, A. E.

“…The pervasive influence of resident microorganisms on the phenotype of their hosts is exemplified by the intracellular bacterium Buchnera aphidicola, which…”
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Colon Cancer Survival Is Associated With Increasing Number of Lymph Nodes Analyzed: A Secondary Survey of Intergroup Trial INT-0089 by LE VOYER, T. E, SIGURDSON, E. R, HANLON, A. L, MAYER, R. J, MACDONALD, J. S, CATALANO, P. J, HALLER, D. G

“…To determine the relationship, in patients with adenocarcinoma of the colon, between survival and the number of lymph nodes analyzed from surgical specimens…”
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Metal-on-metal total hip arthroplasty: the concerns by MacDonald, S J

“…The metal-on-metal bearing couple is having a resurgence in clinical applications seen in total hip and hip resurfacing technologies. The most noteworthy…”
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Assessment of HER2 gene amplification in adenocarcinomas of the stomach or gastroesophageal junction in the INT-0116/SWOG9008 clinical trial by Gordon, M.A., Gundacker, H.M., Benedetti, J., Macdonald, J.S., Baranda, J.C., Levin, W.J., Blanke, C.D., Elatre, W., Weng, P., Zhou, J.Y., Lenz, H.J., Press, M.F.

“…Trastuzumab has been approved for patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic gastric carcinoma; however, relatively…”
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Simultaneous determination of aflatoxins and ochratoxin A in food using a fully automated immunoaffinity column clean-up and liquid chromatography–fluorescence detection by Chan, D., MacDonald, S.J., Boughtflower, V., Brereton, P.

“…An automated HPLC method for the simultaneous detection of aflatoxins (AF) and ochratoxin A (OA) has been developed. The method uses an immunoaffinity column…”
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Adjuvant Therapy in Rectal Cancer: Analysis of Stage, Sex, and Local Control—Final Report of Intergroup 0114 by TEPPER, J. E, O'CONNELL, M, NIEDZWIECKI, D, HOLLIS, D. R, BENSON, A. B, CUMMINGS, B, GUNDERSON, L. L, MACDONALD, J. S, MARTENSON, J. A, MAYER, R. J

“…The gastrointestinal Intergroup studied postoperative adjuvant chemotherapy and radiation therapy in patients with T3/4 and N+ rectal cancer after potentially…”
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Effects of River Discharge, Temperature, and Future Climates on Energetics and Mortality of Adult Migrating Fraser River Sockeye Salmon by Rand, P. S., Hinch, S. G., Morrison, J., Foreman, M. G. G., MacNutt, M. J., Macdonald, J. S., Healey, M. C., Farrell, A. P., Higgs, D. A.

“…We evaluated the effects of past and future trends in temperature and discharge in the Fraser River on the migratory performance of the early Stuart population…”
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Metal-on-metal versus polyethylene in hip arthroplasty: a randomized clinical trial by MacDonald, S J, McCalden, R W, Chess, D G, Bourne, R B, Rorabeck, C H, Cleland, D, Leung, F

“…A prospective, randomized, blinded clinical trial was done to evaluate polyethylene versus metal bearing surfaces in total hip replacement. Forty-one patients…”
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Controlled trial of fluorouracil and low-dose leucovorin given for 6 months as postoperative adjuvant therapy for colon cancer by O'Connell, M J, Mailliard, J A, Kahn, M J, Macdonald, J S, Haller, D G, Mayer, R J, Wieand, H S

“…The goal of this study was to determine the efficacy of intensive-course fluorouracil (5FU) plus low-dose leucovorin given for 6 months following potentially…”
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Biochemical comparisons of osteoarthritic human synovial fluid with calf sera used in knee simulator wear testing by Brandt, J.-M., Brière, L. K., Marr, J., MacDonald, S. J., Bourne, R. B., Medley, J. B.

“…Osteoarthritic human synovial fluid was obtained from the knees of 20 patients and was compared with four different calf sera solutions frequently used as…”
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Efficacy of Reservoir Flow Regulation for Cooling Migration Temperature for Sockeye Salmon in the Nechako River Watershed of British Columbia by Macdonald, J. S, Morrison, J, Patterson, D. A

“…Since the early 1980s, a water temperature management program has been in existence on the Nechako River system in central British Columbia, Canada. The…”
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Tibial Post Wear in Posterior ­Stabilized Total Knee Arthroplasty : An Unrecognized Source of Polyethylene Debris by Puloski, S K.T, McCalden, R W, MacDonald, S J, Rorabeck, C H, Bourne, R B

“…BackgroundWith extensive use of posterior stabilized total knee arthroplasty implants, it is increasingly important to assess the mechanical performance of…”
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Adjuvant therapy of colon cancer by Macdonald, J. S

“…Adjuvant therapy, believed by some to be of no benefit for colorectal cancer as recently as 10 years ago, now offers thousands of patients considerable hope…”
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Genomic evidence for complementary purine metabolism in the pea aphid, Acyrthosiphon pisum, and its symbiotic bacterium Buchnera aphidicola by Ramsey, J.S, MacDonald, S.J, Jander, G, Nakabachi, A, Thomas, G.H, Douglas, A.E

“…The purine salvage pathway recycles purines to nucleotides, promoting efficient utilization of purine nucleotides. Exceptionally among animals with completely…”
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Highly cross-linked polyethylene decreases the rate of revision of total hip arthroplasty compared with conventional polyethylene at 13 years' follow-up by Hanna, S A, Somerville, L, McCalden, R W, Naudie, D D, MacDonald, S J

“…The purpose of this study was to compare the long-term results of primary total hip arthroplasty (THA) in young patients using either a conventional (CPE) or a…”
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Impact of Number of Nodes Retrieved on Outcome in Patients With Rectal Cancer by TEPPER, Joel E, O'CONNELL, Michael J, NIEDZWIECKI, Donna, HOLLIS, Donna, COMPTON, Carolyn, BENSON, Al B, CUMMINGS, Bernard, GUNDERSON, Leonard, MACDONALD, John S, MAYER, Robert J

“…We postulated that the pathologic evaluation of the lymph nodes of surgical specimens from patients with rectal cancer can have a substantial impact on time to…”
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Adjuvant postoperative fluorouracil-modulated chemotherapy combined with pelvic radiation therapy for rectal cancer: initial results of intergroup 0114 by Tepper, J E, O'Connell, M J, Petroni, G R, Hollis, D, Cooke, E, Benson, 3rd, A B, Cummings, B, Gunderson, L L, Macdonald, J S, Martenson, J A

“…The combination of radiation therapy with fluorouracil (5-FU)-based chemotherapy is generally accepted as appropriate postoperative therapy for patients with…”
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