Search Results - "MACCONELL, Leigh A"

Efficacy and tolerability of exenatide monotherapy over 24 weeks in antidiabetic drug—naive patients with type 2 diabetes: A randomized, double-blind, placebo-controlled, parallel-group study by Moretto, Thomas J., MD, Milton, Denái R., MS, Ridge, Terry D., MSN, MacConell, Leigh A., PhD, Okerson, Ted, MD, Wolka, Anne M., PhD, Brodows, Robert G., MD

“…Abstract Background: Evaluation of exenatide monotherapy in patients with type 2 diabetes may be of clinical interest based on improvements in glycemic control…”
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Five-Year Efficacy and Safety Data of Exenatide Once Weekly by Wysham, Carol H., MD, MacConell, Leigh A., PhD, Maggs, David G., MD, Zhou, Ming, PhD, Griffin, Peter S., BA, Trautmann, Michael E., MD

“…Abstract Objective To evaluate the 5-year efficacy and safety of once weekly exenatide. Patients and Methods The Diabetes Therapy Utilization: Researching…”
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The Distribution of Betaglycan Protein and mRNA in Rat Brain, Pituitary, and Gonads: Implications for a Role for Betaglycan in Inhibin-Mediated Reproductive Functions by MacConell, Leigh A, Leal, Angela M. O, Vale, Wylie W

“…Betaglycan was reported by our laboratory to serve as an inhibin binding protein and to facilitate the antagonism of activin signaling. Although an accessory…”
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Five-year efficacy and safety data of exenatide once weekly: long-term results from the DURATION-1 randomized clinical trial by Wysham, Carol H, MacConell, Leigh A, Maggs, David G, Zhou, Ming, Griffin, Peter S, Trautmann, Michael E

“…To evaluate the 5-year efficacy and safety of once weekly exenatide. The Diabetes Therapy Utilization: Researching Changes in A1C, Weight and Other Factors…”
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Baseline Factors Associated With Glycemic Control and Weight Loss When Exenatide Twice Daily Is Added to Optimized Insulin Glargine in Patients With Type 2 Diabetes by ROSENSTOCK, Julio, SHENOUDA, Sylvia K, BERGENSTAL, Richard M, BUSE, John B, GLASS, Leonard C, HEILMANN, Cory R, KWAN, Anita Y. M, MACCONELL, Leigh A, JAMES HOOGWERF, Byron

“…To determine variables associated with glycemic and body weight responses when adding exenatide to basal insulin-treated type 2 diabetes. Exploratory subgroup…”
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Betaglycan binds inhibin and can mediate functional antagonism of activin signalling by Vale, Wylie, Lewis, Kathy A, Gray, Peter C, Blount, Amy L, MacConell, Leigh A, Wiater, Ezra, Bilezikjian, Louise M

“…Activins and inhibins, structurally related members of the TGF-β superfamily of growth and differentiation factors, are mutually antagonistic regulators of…”
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Neuron-Specific Expression in Vivo by Defined Transcription Regulatory Elements of the GnRH Gene by Lawson, Mark A, Macconell, Leigh A, Kim, Jinah, Powl, Brian T, Nelson, Shelley B, Mellon, Pamela L

“…The GnRH-expressing neurons are the ultimate regulator of reproductive function. GnRH gene expression is limited to this small population of neurons in the…”
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Effect of Adenovirus-Mediated Overexpression of Follistatin and Extracellular Domain of Activin Receptor Type II on Gonadotropin Secretion in Vitro and in Vivo by Leal, Angela M. O, Takabe, Kazuaki, Wang, Lili, Donaldson, Cynthia J, MacConell, Leigh A, Bilezikjian, Louise M, Verma, Inder M, Vale, Wylie

“…Activins are dimeric proteins that stimulate the synthesis and secretion of pituitary FSH by interacting with two classes of receptors, type I and type II, to…”
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Adenovirus-mediated overexpression of follistatin enlarges intact liver of adult rats by Takabe, Kazuaki, Wang, Lili, Leal, Angela M.O., MacConell, Leigh A., Wiater, Ezra, Tomiya, Tomoaki, Ohno, Akihiko, Verma, Inder M., Vale, Wylie

“…Under normal physiologic conditions, liver size is under strict regulatory control. Activin, a member of the transforming growth factor β (TGF- β) superfamily,…”
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Activin A regulation of gonadotropin-releasing hormone synthesis and release in vitro by MacConell, L A, Lawson, M A, Mellon, P L, Roberts, V J

“…Activin is essential for the regulation of normal mammalian reproductive function at both the pituitary and gonadal levels. However, its central actions in the…”
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The distribution of betaglycan protein and mRNA in rat brain, pituitary, and gonads: implications for a role for betaglycan in inhibin-mediated reproductive functions by MacConell, Leigh A, Leal, Angela M O, Vale, Wylie W

“…Betaglycan was reported by our laboratory to serve as an inhibin binding protein and to facilitate the antagonism of activin signaling. Although an accessory…”
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Neuron-specific expression in vivo by defined transcription regulatory elements of the GnRH gene by Lawson, Mark A, Macconell, Leigh A, Kim, Jinah, Powl, Brian T, Nelson, Shelley B, Mellon, Pamela L

“…The GnRH-expressing neurons are the ultimate regulator of reproductive function. GnRH gene expression is limited to this small population of neurons in the…”
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Effect of adenovirus-mediated overexpression of follistatin and extracellular domain of activin receptor type II on gonadotropin secretion in vitro and in vivo by Leal, Angela M O, Takabe, Kazuaki, Wang, Lili, Donaldson, Cynthia J, MacConell, Leigh A, Bilezikjian, Louise M, Verma, Inder M, Vale, Wylie

“…Activins are dimeric proteins that stimulate the synthesis and secretion of pituitary FSH by interacting with two classes of receptors, type I and type II, to…”
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Effects of haloperidol in a response-reinstatement model of heroin relapse by ETTENBERG, A, MACCONELL, L. A, GEIST, T. D

“…The present study employed an animal model of drug relapse in which previously extinguished heroin self-administration behavior was reinstated following a…”
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Distribution of follistatin messenger ribonucleic acid in the rat brain: implications for a role in the regulation of central reproductive functions by Macconell, L A, Barth, S, Roberts, V J

“…Follistatin (FS), which binds to the inhibin/activin beta A- or beta B-subunit is localized with and modulates the biological actions of activin in many…”
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Expression of activin and follistatin in the rat hypothalamus: anatomical association with gonadotropin-releasing hormone neurons and possible role of central activin in the regulation of luteinizing hormone release by MacConell, L A, Widger, A E, Barth-Hall, S, Roberts, V J

“…The central role of activin in the regulation of the reproductive axis remains largely unexplored. Evidence suggests that activin may play a role in…”
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Opposite effects of prefrontal cortex and nucleus accumbens infusions of flupenthixol on stimulant-induced locomotion and brain stimulation reward by Duvauchelle, C L, Levitin, M, MacConell, L A, Lee, L K, Ettenberg, A

“…Ventral tegmental area (VTA) stimulation produced conditioned place preferences for stimulation-paired environments the magnitudes of which were…”
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Expression of activin and follistatin in the rat hypothalamus by MacConell Leigh A Dr, Widger, Amy E, Barth-Hall, Sara, Roberts, Veronica J

“…The central role of activin in the regulation of the reproductive axis remains largely unexplored. Evidence suggests that activin may play a role in…”
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Pimozide prevents the development of conditioned place preferences induced by rewarding locus coeruleus stimulation by Duvauchelle, C L, MacConell, L A, Eremia, A D, Ettenberg, A

“…Electrical stimulation in the vicinity of the cell bodies of the locus coeruleus (LC) has been shown to support self-stimulation behaviors in rats. In the…”
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