Search Results - "MACARY, Paul A"

The trinity of COVID-19: immunity, inflammation and intervention by Tay, Matthew Zirui, Poh, Chek Meng, Rénia, Laurent, MacAry, Paul A., Ng, Lisa F. P.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic. Alongside…”
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The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody by Chan, Conrad E. Z, Seah, Shirley G. K, Chye, De Hoe, Massey, Shane, Torres, Maricela, Lim, Angeline P. C, Wong, Steven K. K, Neo, Jacklyn J. Y, Wong, Pui San, Lim, Jie Hui, Loh, Gary S. L, Wang, Dongling, Boyd-Kirkup, Jerome D, Guan, Siyu, Thakkar, Dipti, Teo, Guo Hui, Purushotorman, Kiren, Hutchinson, Paul E, Young, Barnaby E, Low, Jenny G, MacAry, Paul A, Hentze, Hannes, Prativadibhayankara, Venkateshan S, Ethirajulu, Kantharaj, Comer, Jason E, Tseng, Chien-Te K, Barrett, Alan D. T, Ingram, Piers J, Brasel, Trevor, Hanson, Brendon John

“…Although SARS-CoV-2-neutralizing antibodies are promising therapeutics against COVID-19, little is known about their mechanism(s) of action or effective dosing…”
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cGAS–STING cytosolic DNA sensing pathway is suppressed by JAK2-STAT3 in tumor cells by Suter, Manuel Adrian, Tan, Nikki Y., Thiam, Chung Hwee, Khatoo, Muznah, MacAry, Paul A., Angeli, Veronique, Gasser, Stephan, Zhang, Y. L.

“…Deficiencies in DNA repair and DNA degrading nucleases lead to accumulation of cytosolic DNA. cGAS is a critical DNA sensor for the detection of cytosolic DNA…”
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SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets by Raghuvamsi, Palur V, Tulsian, Nikhil K, Samsudin, Firdaus, Qian, Xinlei, Purushotorman, Kiren, Yue, Gu, Kozma, Mary M, Hwa, Wong Y, Lescar, Julien, Bond, Peter J, MacAry, Paul A, Anand, Ganesh S

“…The spike (S) protein is the main handle for SARS-CoV-2 to enter host cells via surface angiotensin-converting enzyme 2 (ACE2) receptors. How ACE2 binding…”
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Identification of B-Cell Epitopes for Eliciting Neutralizing Antibodies against the SARS-CoV-2 Spike Protein through Bioinformatics and Monoclonal Antibody Targeting by Lim, Hui Xuan, Masomian, Malihe, Khalid, Kanwal, Kumar, Asqwin Uthaya, MacAry, Paul A, Poh, Chit Laa

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global public health crisis. Effective COVID-19 vaccines developed by…”
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Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose by Renia, Laurent, Goh, Yun Shan, Rouers, Angeline, Le Bert, Nina, Chia, Wan Ni, Chavatte, Jean-Marc, Fong, Siew‐Wai, Chang, Zi Wei, Zhuo, Nicole Ziyi, Tay, Matthew Zirui, Chan, Yi-Hao, Tan, Chee Wah, Yeo, Nicholas Kim‐Wah, Amrun, Siti Naqiah, Huang, Yuling, Wong, Joel Xu En, Hor, Pei Xiang, Loh, Chiew Yee, Wang, Bei, Ngoh, Eve Zi Xian, Salleh, Siti Nazihah Mohd, Carissimo, Guillaume, Dowla, Samanzer, Lim, Alicia Jieling, Zhang, Jinyan, Lim, Joey Ming Er, Wang, Cheng-I., Ding, Ying, Pada, Surinder, Sun, Louisa Jin, Somani, Jyoti, Lee, Eng Sing, Ong, Desmond Luan Seng, Leo, Yee‐Sin, MacAry, Paul A., Lin, Raymond Tzer Pin, Wang, Lin-Fa, Ren, Ee Chee, Lye, David C., Bertoletti, Antonio, Young, Barnaby Edward, Ng, Lisa F. P.

“…Understanding the impact of age on vaccinations is essential for the design and delivery of vaccines against SARS-CoV-2. Here, we present findings from a…”
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Differential Targeting of Viral Components by CD4+ versus CD8+ T Lymphocytes in Dengue Virus Infection by Rivino, Laura, Kumaran, Emmanuelle A P, Jovanovic, Vojislav, Nadua, Karen, Teo, En Wei, Pang, Shyue Wei, Teo, Guo Hui, Gan, Victor Chih Hao, Lye, David C, Leo, Yee Sin, Hanson, Brendon J, Smith, Kenneth G C, Bertoletti, Antonio, Kemeny, David M, MacAry, Paul A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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NK cells are activated and primed for skin-homing during acute dengue virus infection in humans by Zimmer, Christine L., Cornillet, Martin, Solà-Riera, Carles, Cheung, Ka-Wai, Ivarsson, Martin A., Lim, Mei Qiu, Marquardt, Nicole, Leo, Yee-Sin, Lye, David Chien, Klingström, Jonas, MacAry, Paul A., Ljunggren, Hans-Gustaf, Rivino, Laura, Björkström, Niklas K.

“…Despite animal models showing that natural killer (NK) cells are important players in the early defense against many viral infections, the NK cell response is…”
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The role of phage display in therapeutic antibody discovery by Chan, Conrad E Z, Lim, Angeline P C, MacAry, Paul A, Hanson, Brendon J

“…Phage display involves the expression of selected proteins on the surface of filamentous phage through fusion with phage coat protein, with the genetic…”
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Cross-Reactivity and Anti-viral Function of Dengue Capsid and NS3-Specific Memory T Cells Toward Zika Virus by Lim, Mei Qiu, Kumaran, Emmanuelle A P, Tan, Hwee Cheng, Lye, David C, Leo, Yee Sin, Ooi, Eng Eong, MacAry, Paul A, Bertoletti, Antonio, Rivino, Laura

“…Zika virus (ZIKV), a flavivirus with homology to dengue virus (DENV), is spreading to areas of DENV hyper-endemicity. Heterologous T cell immunity, whereby…”
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Codominant IgG and IgA expression with minimal vaccine mRNA in milk of BNT162b2 vaccinees by Low, Jia Ming, Gu, Yue, Ng, Melissa Shu Feng, Amin, Zubair, Lee, Le Ye, Ng, Yvonne Peng Mei, Shunmuganathan, Bhuvaneshwari D/O, Niu, Yuxi, Gupta, Rashi, Tambyah, Paul Anantharajah, MacAry, Paul A., Wang, Liang Wei, Zhong, Youjia

“…Lactating women can produce protective antibodies in their milk after vaccination, which has informed antenatal vaccination programs for diseases such as…”
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Hydrogen sulfide and neurogenic inflammation in polymicrobial sepsis: involvement of substance P and ERK-NF-κB signaling by Ang, Seah-Fang, Moochhala, Shabbir M, MacAry, Paul A, Bhatia, Madhav

“…Hydrogen sulfide (H(2)S) has been shown to induce transient receptor potential vanilloid 1 (TRPV1)-mediated neurogenic inflammation in polymicrobial sepsis…”
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The structural basis for serotype-specific neutralization of dengue virus by a human antibody by Teoh, Ee Ping, Kukkaro, Petra, Teo, En Wei, Lim, Angeline P C, Tan, Tze Tong, Yip, Andy, Schul, Wouter, Aung, Myint, Kostyuchenko, Victor A, Leo, Yee Sin, Chan, Soh Ha, Smith, Kenneth G C, Chan, Annie Hoi Yi, Zou, Gang, Ooi, Eng Eong, Kemeny, D Michael, Tan, Grace K, Ng, Jowin K W, Ng, Mah Lee, Alonso, Sylvie, Fisher, Dale, Shi, Pei-Yong, Hanson, Brendon J, Lok, Shee-Mei, MacAry, Paul A

“…Dengue virus (DENV) is a mosquito-borne flavivirus that affects 2.5 billion people worldwide. There are four dengue serotypes (DENV1 to DENV4), and infection…”
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Structure and Function: Heat Shock Proteins and Adaptive Immunity by Javid, Babak, MacAry, Paul A, Lehner, Paul J

“…Heat shock proteins (HSPs) have been implicated in the stimulation and generation of both innate and adaptive immunity. The ability of HSPs to bind antigenic…”
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Influenza A Virus Infection Results in a Robust, Antigen-Responsive, and Widely Disseminated Foxp3+ Regulatory T Cell Response by BETTS, Richard J, PRABHU, Nayana, HO, Adrian W. S, FEI CHUIN LEW, HUTCHINSON, Paul E, ROTZSCHKE, Olaf, MACARY, Paul A, KEMENY, D. Michael

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Global Assessment of Dengue Virus-Specific CD4 + T Cell Responses in Dengue-Endemic Areas by Grifoni, Alba, Angelo, Michael A, Lopez, Benjamin, O'Rourke, Patrick H, Sidney, John, Cerpas, Cristhiam, Balmaseda, Angel, Silveira, Cassia G T, Maestri, Alvino, Costa, Priscilla R, Durbin, Anna P, Diehl, Sean A, Phillips, Elizabeth, Mallal, Simon, De Silva, Aruna D, Nchinda, Godwin, Nkenfou, Celine, Collins, Matthew H, de Silva, Aravinda M, Lim, Mei Qiu, Macary, Paul A, Tatullo, Filippo, Solomon, Tom, Satchidanandam, Vijaya, Desai, Anita, Ravi, Vasanthapram, Coloma, Josefina, Turtle, Lance, Rivino, Laura, Kallas, Esper G, Peters, Bjoern, Harris, Eva, Sette, Alessandro, Weiskopf, Daniela

“…Dengue is a major public health problem worldwide. Assessment of adaptive immunity is important to understanding immunopathology and to define correlates of…”
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Employment of a high throughput functional assay to define the critical factors that influence vaccine induced cross-variant neutralizing antibodies for SARS-CoV-2 by Gu, Yue, Shunmuganathan, Bhuvaneshwari, Qian, Xinlei, Gupta, Rashi, Tan, Rebecca S. W., Kozma, Mary, Purushotorman, Kiren, Murali, Tanusya M., Tan, Nikki Y. J., Preiser, Peter R., Lescar, Julien, Nasir, Haziq, Somani, Jyoti, Tambyah, Paul A., Smith, Kenneth G. C., Renia, Laurent, Ng, Lisa F. P., Lye, David C., Young, Barnaby E., MacAry, Paul A.

“…The scale and duration of neutralizing antibody responses targeting SARS-CoV-2 viral variants represents a critically important serological parameter that…”
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Nonstimulatory peptide–MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling by Zhao, Xiang, Sankaran, Shvetha, Yap, Jiawei, Too, Chien Tei, Ho, Zi Zong, Dolton, Garry, Legut, Mateusz, Ren, Ee Chee, Sewell, Andrew K., Bertoletti, Antonio, MacAry, Paul A., Brzostek, Joanna, Gascoigne, Nicholas R. J.

“…Foreign antigens are presented by antigen-presenting cells in the presence of abundant endogenous peptides that are nonstimulatory to the T cell. In mouse T…”
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Hydrogen sulfide upregulates cyclooxygenase-2 and prostaglandin E metabolite in sepsis-evoked acute lung injury via transient receptor potential vanilloid type 1 channel activation by Ang, Seah-Fang, Sio, Selena W S, Moochhala, Shabbir M, MacAry, Paul A, Bhatia, Madhav

“…Hydrogen sulfide (H(2)S) has been shown to promote transient receptor potential vanilloid type 1 (TRPV1)-mediated neurogenic inflammation in sepsis and its…”
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Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A11:01 by Gu, Yue, Wong, Yee Hwa, Liew, Chong Wai, Chan, Conrad E. Z., Murali, Tanusya M., Yap, Jiawei, Too, Chien Tei, Purushotorman, Kiren, Hamidinia, Maryam, El Sahili, Abbas, Goh, Angeline T. H., Teo, Rachel Z. C., Wood, Kathryn J., Hanson, Brendon J., Gascoigne, Nicholas R. J., Lescar, Julien, Vathsala, Anantharaman, MacAry, Paul A.

“…Our understanding of the conformational and electrostatic determinants that underlie targeting of human leukocyte antigens (HLA) by anti-HLA alloantibodies is…”
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