Search Results - "MACALUSO, Jennifer"

Staying Ahead of the Curve: Monitoring Epidemiology and Geographic Distribution by Zip Code of Enterovirus D68 by Macaluso, Jennifer D., BSN, RN, Weissenbach, Matthew, MPH, CPH, CIC

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A fully human monoclonal antibody (CR002) identifies PDGF-D as a novel mediator of mesangioproliferative glomerulonephritis by OSTENDORF, Tammo, VAN ROEYEN, Claudia R. C, KEYT, Bruce A, LICHENSTEIN, Henri S, LAROCHELLE, William J, FLOEGE, Jürgen, PETERSON, Jeffrey D, KUNTER, Uta, EITNER, Frank, HAMAD, Avin J, CHAN, Gerlinde, JIA, Xiao-Chi, MACALUSO, Jennifer, GAZIT-BORNSTEIN, Gadi

“…PDGF-B is of central importance in mesangioproliferative diseases. PDGF-D, a new PDGF isoform, like PDGF-B, signals through the PDGF betabeta-receptor. The…”
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Discovery of GS-9973, a Selective and Orally Efficacious Inhibitor of Spleen Tyrosine Kinase by Currie, Kevin S, Kropf, Jeffrey E, Lee, Tony, Blomgren, Peter, Xu, Jianjun, Zhao, Zhongdong, Gallion, Steve, Whitney, J. Andrew, Maclin, Deborah, Lansdon, Eric B, Maciejewski, Patricia, Rossi, Ann Marie, Rong, Hong, Macaluso, Jennifer, Barbosa, James, Di Paolo, Julie A, Mitchell, Scott A

“…Spleen tyrosine kinase (Syk) is an attractive drug target in autoimmune, inflammatory, and oncology disease indications. The most advanced Syk inhibitor, R406,…”
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Oral Estrogen Receptor PROTAC Vepdegestrant (ARV-471) Is Highly Efficacious as Monotherapy and in Combination with CDK4/6 or PI3K/mTOR Pathway Inhibitors in Preclinical ER+ Breast Cancer Models by Gough, Sheryl M, Flanagan, John J, Teh, Jessica, Andreoli, Monica, Rousseau, Emma, Pannone, Melissa, Bookbinder, Mark, Willard, Ryan, Davenport, Kim, Bortolon, Elizabeth, Cadelina, Gregory, Gordon, Debbie, Pizzano, Jennifer, Macaluso, Jennifer, Soto, Leofal, Corradi, John, Digianantonio, Katherine, Drulyte, Ieva, Morgan, Alicia, Quinn, Connor, Békés, Miklós, Ferraro, Caterina, Chen, Xin, Wang, Gan, Dong, Hanqing, Wang, Jing, Langley, David R, Houston, John, Gedrich, Richard, Taylor, Ian C

“…Estrogen receptor (ER) alpha signaling is a known driver of ER-positive (ER+)/human epidermal growth factor receptor 2 negative (HER2-) breast cancer…”
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Abstract 43: Discovery of ARV-110, a first in class androgen receptor degrading PROTAC for the treatment of men with metastatic castration resistant prostate cancer by Snyder, Lawrence B., Neklesa, Taavi K., Chen, Xin, Dong, Hanqing, Ferraro, Caterina, Gordon, Deborah A., Macaluso, Jennifer, Pizzano, Jennifer, Wang, Jing, Willard, Ryan R., Vitale, Nicholas, Peck, Ron, Moore, Marcia Dougan, Crews, Craig M., Houston, John, Crew, Andrew P., Taylor, Ian

“…Prostate cancer is the second leading cause of cancer death in men in the United States. The androgen receptor (AR) plays critical roles in both early disease…”
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Regulated induced proximity targeting chimeras-RIPTACs-A heterobifunctional small molecule strategy for cancer selective therapies by Raina, Kanak, Forbes, Chris D, Stronk, Rebecca, Rappi, Jr, Jonathan P, Eastman, Kyle J, Zaware, Nilesh, Yu, Xinheng, Li, Hao, Bhardwaj, Amit, Gerritz, Samuel W, Forgione, Mia, Hundt, Abigail, King, Madeline P, Posner, Zoe M, Correia, Allison D, McGovern, Andrew, Puleo, David E, Chenard, Rebekka, Mousseau, James J, Vergara, J Ignacio, Garvin, Ethan, Macaluso, Jennifer, Martin, Michael, Bassoli, Kyle, Jones, Kelli, Garcia, Marco, Howard, Katia, Yaggi, Madeleine, Smith, Levi M, Chen, Jinshan M, Mayfield, Andrew B, De Leon, Cesar A, Hines, John, Kayser-Bricker, Katherine J, Crews, Craig M

“…We describe a protein proximity inducing therapeutic modality called Regulated Induced Proximity Targeting Chimeras or RIPTACs: heterobifunctional small…”
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ARV-110: An oral androgen receptor PROTAC degrader for prostate cancer by Neklesa, Taavi, Snyder, Lawrence B, Willard, Ryan R, Vitale, Nicholas, Pizzano, Jennifer, Gordon, Deborah A, Bookbinder, Mark, Macaluso, Jennifer, Dong, Hanqing, Ferraro, Caterina, Wang, Gan, Wang, Jing, Crews, Craig M, Houston, John, Crew, Andrew P, Taylor, Ian

“…Abstract only 259 Background: The Androgen Receptor (AR) remains the principal driver of castration-resistant prostate cancer during the transition from a…”
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Abstract 5236: ARV-110: An androgen receptor PROTAC degrader for prostate cancer by Neklesa, Taavi, Snyder, Lawrence B., Willard, Ryan R., Vitale, Nicholas, Raina, Kanak, Pizzano, Jennifer, Gordon, Deborah, Bookbinder, Mark, Macaluso, Jennifer, Dong, Hanqing, Liu, Zheng, Ferraro, Caterina, Wang, Gan, Wang, Jing, Crews, Craig M., Houston, John, Crew, Andrew P., Taylor, Ian

“…The Androgen Receptor (AR) remains the principal driver of castration-resistant prostate cancer during the transition from a localized to metastatic disease…”
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An oral androgen receptor PROTAC degrader for prostate cancer by Neklesa, Taavi, Snyder, Lawrence B, Willard, Ryan R, Vitale, Nicholas, Raina, Kanak, Pizzano, Jennifer, Gordon, Deborah A, Bookbinder, Mark, Macaluso, Jennifer, Dong, Hanqing, Liu, Zheng, Ferraro, Caterina, Wang, Gan, Wang, Jing, Crews, Craig M, Houston, John, Crew, Andrew P, Taylor, Ian

“…Abstract only 381 Background: The Androgen Receptor (AR) remains the principal driver of castration-resistant prostate cancer during the transition from a…”
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Abstract 5637: An oral Androgen Receptor PROTAC degrader for prostate cancer by Neklesa, Taavi K., Snyder, Lawrence B., Bookbinder, Mark, Chen, Xin, Crew, Andrew P., Crews, Craig M., Dong, Hanqing, Gordon, Deborah, Macaluso, Jennifer, Raina, Kanak, Rossi, AnnMarie, Taylor, Ian, Vitale, Nicholas, Wang, Jing, Willard, Ryan R., Zimmermann, Kurt

“…The Androgen Receptor (AR) remains the principal driver of castration-resistant prostate cancer during the transition from a localized to metastatic disease…”
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Platelet-derived growth factor D: Tumorigenicity in mice and dysregulated expression in human cancer by LAROCHELLE, William J, JEFFERS, Michael, MAYOTTE, Jane, MACALUSO, Jennifer, RITTMAN, Beth, WU, Frank, DHANABAL, Mohan, HERRMANN, John, LICHENSTEIN, Henri S, CORVALAN, Jose R. F, JIA, Xiao-Chi, XIAO FENG, VANEGAS, Sandra, VICKROY, Justin D, YANG, Xiao-Dong, CHEN, Francine, GAZIT, Gadi

“…Platelet-derived growth factor (PDGF) has been directly implicated in developmental and physiological processes, as well as in human cancer and other…”
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