Search Results - "MAAMARY, Jad"

Signaling by Antibodies: Recent Progress by Bournazos, Stylianos, Wang, Taia T, Dahan, Rony, Maamary, Jad, Ravetch, Jeffrey V

“…IgG antibodies mediate a diversity of immune functions by coupling of antigen specificity through the Fab domain to signal transduction via Fc-Fc receptor…”
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General mechanism for modulating immunoglobulin effector function by Sondermann, Peter, Pincetic, Andrew, Maamary, Jad, Lammens, Katja, Ravetch, Jeffrey V.

“…Immunoglobulins recognize and clear microbial pathogens and toxins through the coupling of variable region specificity to Fc-triggered cellular activation…”
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BioPhi: A platform for antibody design, humanization, and humanness evaluation based on natural antibody repertoires and deep learning by Prihoda, David, Maamary, Jad, Waight, Andrew, Juan, Veronica, Fayadat-Dilman, Laurence, Svozil, Daniel, Bitton, Danny A

“…Despite recent advances in transgenic animal models and display technologies, humanization of mouse sequences remains one of the main routes for therapeutic…”
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Protection in antibody- and T cell-mediated autoimmune diseases by antiinflammatory IgG Fcs requires type II FcRs by Fiebiger, Benjamin M., Maamary, Jad, Pincetic, Andrew, Ravetch, Jeffrey V.

“…The antiinflammatory activity of intravenous immunoglobulin (IVIG) is dependent on the presence of sialic acid in the core IgG fragment crystallizable domain…”
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Anti-HA Glycoforms Drive B Cell Affinity Selection and Determine Influenza Vaccine Efficacy by Wang, Taia T., Maamary, Jad, Tan, Gene S., Bournazos, Stylianos, Davis, Carl W., Krammer, Florian, Schlesinger, Sarah J., Palese, Peter, Ahmed, Rafi, Ravetch, Jeffrey V.

“…Protective vaccines elicit high-affinity, neutralizing antibodies by selection of somatically hypermutated B cell antigen receptors (BCR) on immune complexes…”
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Influenza Viruses Expressing Chimeric Hemagglutinins: Globular Head and Stalk Domains Derived from Different Subtypes by Hai, Rong, Krammer, Florian, Tan, Gene S, Pica, Natalie, Eggink, Dirk, Maamary, Jad, Margine, Irina, Albrecht, Randy A, Palese, Peter

“…The influenza virus hemagglutinin molecule possesses a globular head domain that mediates receptor binding and a stalk domain at the membrane-proximal region…”
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Increasing the breadth and potency of response to the seasonal influenza virus vaccine by immune complex immunization by Maamary, Jad, Wang, Taia T., Tan, Gene S., Palese, Peter, Ravetch, Jeffrey V.

“…The main barrier to reduction of morbidity caused by influenza is the absence of a vaccine that elicits broad protection against different virus strains…”
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Hemagglutinin stalk antibodies elicited by the 2009 pandemic influenza virus as a mechanism for the extinction of seasonal H1N1 viruses by Pica, Natalie, Hai, Rong, Krammer, Florian, Wang, Taia T., Maamary, Jad, Eggink, Dirk, Tan, Gene S., Krause, Jens C., Moran, Thomas, Stein, Cheryl R., Banach, David, Wrammert, Jens, Belshe, Robert B., García-Sastre, Adolfo, Palese, Peter

“…After the emergence of pandemic influenza viruses in 1957, 1968, and 2009, existing seasonal viruses were observed to be replaced in the human population by…”
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Host- and strain-specific regulation of influenza virus polymerase activity by interacting cellular proteins by Bortz, Eric, Westera, Liset, Maamary, Jad, Steel, John, Albrecht, Randy A, Manicassamy, Balaji, Chase, Geoffrey, Martínez-Sobrido, Luis, Schwemmle, Martin, García-Sastre, Adolfo

“…Highly pathogenic avian influenza A (HPAI) viruses of the H5N1 subtype have recently emerged from avian zoonotic reservoirs to cause fatal human disease…”
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Newcastle Disease Virus Expressing a Dendritic Cell-Targeted HIV Gag Protein Induces a Potent Gag-Specific Immune Response in Mice by Maamary, Jad, Array, Frida, Gao, Qinshan, García-Sastre, Adolfo, Steinman, Ralph M., Palese, Peter, Nchinda, Godwin

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A novel small molecule inhibitor of influenza A viruses that targets polymerase function and indirectly induces interferon by Ortigoza, Mila Brum, Dibben, Oliver, Maamary, Jad, Martinez-Gil, Luis, Leyva-Grado, Victor H, Abreu, Jr, Pablo, Ayllon, Juan, Palese, Peter, Shaw, Megan L

“…Influenza viruses continue to pose a major public health threat worldwide and options for antiviral therapy are limited by the emergence of drug-resistant…”
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Poly-ADP Ribosyl Polymerase 1 (PARP1) Regulates Influenza A Virus Polymerase by García-Sastre, Adolfo, Schwemmle, Martin, Maamary, Jad, Jennings, Alisha M., Westera, Liset, Bortz, Eric

“…Influenza A viruses (IAV) are evolutionarily successful pathogens, capable of infecting a number of avian and mammalian species and responsible for pandemic…”
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Reply to Crispin et al.: Molecular model that accounts for the biological and physical properties of sialylated Fc by Sondermann, Peter, Pincetic, Andrew, Maamary, Jad, Lammens, Katja, Ravetch, Jeffrey V

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Recombinant Influenza A Viruses with Enhanced Levels of PB1 and PA Viral Protein Expression by Belicha-Villanueva, Alan, Rodriguez-Madoz, Juan R., Maamary, Jad, Baum, Alina, Bernal-Rubio, Dabeiba, Minguito de la Escalera, Maria, Fernandez-Sesma, Ana, García-Sastre, Adolfo

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Attenuated Influenza Virus Construct with Enhanced Hemagglutinin Protein Expression by MAAMARY, Jad, PICA, Natalie, BELICHA-VILLANUEVA, Alan, CHOU, Yi-Ying, KRAMMER, Florian, QINSHAN GAO, GARCIA-SASTRE, Adolfo, PALESE, Peter

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574. Models of Cancer Cachexia: Treatment with Inhibition of NF-kB by Maamary, Jad R., Jiang, Zhilong, Clemens, Paula R.

“…Cachexia is associated with life-threatening diseases, such as cancer and AIDS, especially gastrointestinal tract and lung cancer, where it contributes to the…”
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Implementing a Clinical Immunogenicity Strategy using Preclinical Risk Assessment Outputs by Jawa, Vibha, Maamary, Jad, Swanson, Michael, Zhang, Shuli, Montgomery, Diana

“…Immunogenicity to biologics is often observed following dosing in human subjects during clinical trials. Both product and host specific factors may be…”
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Type I and type II Fc receptors regulate innate and adaptive immunity by Pincetic, Andrew, Bournazos, Stylianos, DiLillo, David J, Maamary, Jad, Wang, Taia T, Dahan, Rony, Fiebiger, Benjamin-Maximillian, Ravetch, Jeffrey V

“…Antibodies produced in response to a foreign antigen are characterized by polyclonality, not only in the diverse epitopes to which their variable domains bind…”
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Competition-Based Cell Assay Employing Soluble T Cell Receptors to Assess MHC Class II Antigen Processing and Presentation by Tasker, Carley, Patel, Jenny, Jawa, Vibha, Maamary, Jad

“…Accurate assessment of antigen-specific immune responses is critical in the development of safe and efficacious biotherapeutics and vaccines. Endosomal…”
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IgG anti-HA Fc glycoform modulation is predictive of influenza vaccine efficacy (IRC10P.412) by Wang, Taia, Maamary, Jad, Schlesinger, Sarah, Ravetch, Jeffrey

“…Abstract Protective anti-viral vaccines elicit high affinity, antigen-specific neutralizing antibodies through secondary diversification mechanisms involving…”
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