Search Results - "M.-C. Potier"

Classification of Human Chromosome 21 Gene-Expression Variations in Down Syndrome: Impact on Disease Phenotypes by Aït Yahya-Graison, E., Aubert, J., Dauphinot, L., Rivals, I., Prieur, M., Golfier, G., Rossier, J., Personnaz, L., Créau, N., Bléhaut, H., Robin, S., Delabar, J.M., Potier, M.-C.

“…Down syndrome caused by chromosome 21 trisomy is the most common genetic cause of mental retardation in humans. Disruption of the phenotype is thought to be…”
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Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice by Braudeau, J, Delatour, B, Duchon, A, Pereira, P Lopes, Dauphinot, L, de Chaumont, F, Olivo-Marin, J-C, Dodd, RH, Hérault, Y, Potier, M-C

“…An imbalance between inhibitory and excitatory neurotransmission has been proposed to contribute to altered brain function in individuals with Down syndrome…”
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Integrating whole transcriptome assays on a lab-on-a-chip for single cell gene profiling by Bontoux, N, Dauphinot, L, Vitalis, T, Studer, V, Chen, Y, Rossier, J, Potier, M-C

“…To correlate gene expression profiles to fundamental biological processes such as cell growth, differentiation and migration, it is essential to work at the…”
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Combined assessment of DYRK1A, BDNF and homocysteine levels as diagnostic marker for Alzheimer’s disease by Janel, N, Alexopoulos, P, Badel, A, Lamari, F, Camproux, A C, Lagarde, J, Simon, S, Feraudet-Tarisse, C, Lamourette, P, Arbones, M, Paul, J L, Dubois, B, Potier, M C, Sarazin, M, Delabar, J M

“…Early identification of Alzheimer’s disease (AD) risk factors would aid development of interventions to delay the onset of dementia, but current biomarkers are…”
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Parvalbumin deficiency affects network properties resulting in increased susceptibility to epileptic seizures by Schwaller, B, Tetko, I.V, Tandon, P, Silveira, D.C, Vreugdenhil, M, Henzi, T, Potier, M.-C, Celio, M.R, Villa, A.E.P

“…Networks of GABAergic interneurons are of utmost importance in generating and promoting synchronous activity and are involved in producing coherent…”
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Transmembrane protein 50b ( C21orf4 ), a candidate for Down syndrome neurophenotypes, encodes an intracellular membrane protein expressed in the rodent brain by Moldrich, R.X, Lainé, J, Visel, A, Beart, P.M, Laffaire, J, Rossier, J, Potier, M.-C

“…Abstract Transmembrane protein 50b, Tmem50b , previously referred to as C21orf4 , encodes a predicted transmembrane protein and is one of few genes…”
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The cerebellar transcriptome during postnatal development of the Ts1Cje mouse, a segmental trisomy model for Down syndrome by Dauphinot, L., Lyle, R., Rivals, I., Dang, M. Tran, Moldrich, R.X., Golfier, G., Ettwiller, L., Toyama, K., Rossier, J., Personnaz, L., Antonarakis, S.E., Epstein, C.J., Sinet, P.-M., Potier, M.-C.

“…The central nervous system of persons with Down syndrome presents cytoarchitectural abnormalities that likely result from gene-dosage effects affecting the…”
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Transcriptional disruptions in Down syndrome: a case study in the Ts1Cje mouse cerebellum during post‐natal development by Potier, M.‐C., Rivals, I., Mercier, G., Ettwiller, L., Moldrich, R. X., Laffaire, J., Personnaz, L., Rossier, J., Dauphinot, L.

“…To understand the aetiology and the phenotypic severity of Down syndrome, we searched for transcriptional signatures in a substructure of the brain…”
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Chronic Treatment with a Promnesiant GABA-A α5-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model by Braudeau, J., Dauphinot, L., Duchon, A., Loistron, A., Dodd, R. H., Hérault, Y., Delatour, B., Potier, M. C.

“…Decrease of GABAergic transmission has been proposed to improve memory functions. Indeed, inverse agonists selective for α5 GABA-A-benzodiazepine receptors…”
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Modifications of the endosomal compartment in peripheral blood mononuclear cells and fibroblasts from Alzheimer’s disease patients by Corlier, F, Rivals, I, Lagarde, J, Hamelin, L, Corne, H, Dauphinot, L, Ando, K, Cossec, J-C, Fontaine, G, Dorothée, G, Malaplate-Armand, C, Olivier, J-L, Dubois, B, Bottlaender, M, Duyckaerts, C, Sarazin, M, Potier, M-C

“…Identification of blood-based biomarkers of Alzheimer’s disease (AD) remains a challenge. Neuropathological studies have identified enlarged endosomes in…”
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Selection of oligonucleotides for whole-genome microarrays with semi-automatic update by Golfier, G., Lemoine, S., van Miltenberg, A., Bendjoudi, A., Rossier, J., Le Crom, S., Potier, M.-C.

“…Oligonucleotide microarray probes are designed to match specific transcripts present in databases that are regularly updated. As a consequence probes should be…”
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VARAN: a web server for Variability Analysis of DNA microarray experiments by Golfier, G., Dang, M. Tran, Dauphinot, L., Graison, E., Rossier, J., Potier, M.-C.

“…Here, we describe a tool for VARiability Analysis of DNA microarrays experiments (VARAN), a freely available Web server that performs a signal intensity based…”
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Cloning and sequencing of the cDNA encoding an isoform of microtubule‐associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain by Goedert, M., Spillantini, M. G., Potier, M. C., Ulrich, J., Crowther, R. A.

“…We have isolated cDNA clones encoding a 383‐amino acid isoform of the human microtubule‐associated protein tau. It differs from previously determined tau…”
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Transcription Profile Analysis Reveals That OBP-1F mRNA Is Downregulated in the Olfactory Mucosa Following Food Deprivation by Badonnel, K, Denis, J-B, Caillol, M, Monnerie, R, Piumi, F, Potier, M-C, Salesse, R, Baly, C

“…Neuroanatomical data show that olfactory mucosa (OM) is a possible place for interactions between nutrition and smell. A combination of differential display…”
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HtrA1-dependent proteolysis of TGF-β controls both neuronal maturation and developmental survival by Launay, S, Maubert, E, Lebeurrier, N, Tennstaedt, A, Campioni, M, Docagne, F, Gabriel, C, Dauphinot, L, Potier, M C, Ehrmann, M, Baldi, A, Vivien, D

“…Transforming growth factor- β (TGF- β ) signalling controls a number of cerebral functions and dysfunctions including synaptogenesis, amyloid- β accumulation,…”
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Sustained calcium signalling and caspase-3 activation involve NMDA receptors in thymocytes in contact with dendritic cells by Affaticati, P, Mignen, O, Jambou, F, Potier, M-C, Klingel-Schmitt, I, Degrouard, J, Peineau, S, Gouadon, E, Collingridge, G L, Liblau, R, Capiod, T, Cohen-Kaminsky, S

“…L-glutamate, the major excitatory neurotransmitter, also has a role in non-neuronal tissues and modulates immune responses. Whether NMDA receptor (NMDAR)…”
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The Human Myosin Light Chain Kinase (MLCK) from Hippocampus: Cloning, Sequencing, Expression, and Localization to 3qcen–q21 by POTIER, M.-C., CHELOT, E., PEKARSKY, Y., GARDINER, K., ROSSIER, J., TURNELL, W.G.

“…Myosin light chain kinase (MLCK), a key enzyme in muscle contraction, has been shown by immunohistology to be present in neurons and glia. We describe here the…”
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Innovative instrumentation for microarray scanning and analysis: application for characterization of oligonucleotide duplexes behavior by Khomyakova, E B, Dreval, E V, Tran-Dang, M, Potier, M C, Soussaline, F P

“…Accuracy in microarray technology requires new approaches to microarray reader development. A microarray reader system (optical scanning array or OSA reader)…”
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Plasma DYRK1A as a novel risk factor for Alzheimer’s disease by Janel, N, Sarazin, M, Corlier, F, Corne, H, de Souza, L C, Hamelin, L, Aka, A, Lagarde, J, Blehaut, H, Hindié, V, Rain, J-C, Arbones, M L, Dubois, B, Potier, M C, Bottlaender, M, Delabar, J M

“…To determine whether apparent involvement of DYRK1A in Alzheimer’s disease (AD) pathology makes it a candidate plasma biomarker for diagnosis, we developed a…”
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Bacterial contig map of the 21q11 region associated with Alzheimer's disease and abnormal myelopoiesis in Down syndrome by Groet, J, Ives, J H, South, A P, Baptista, P R, Jones, T A, Yaspo, M L, Lehrach, H, Potier, M C, Van Broeckhoven, C, Nizetić, D

“…We present a high-resolution bacterial contig map of 3.4 Mb of genomic DNA in human chromosome 21q11-q21, encompassing the region of elevated disomic…”
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