Search Results - "M. van Vugt"

ATR inhibition preferentially targets homologous recombination-deficient tumor cells by Krajewska, M, Fehrmann, R S N, Schoonen, P M, Labib, S, de Vries, E G E, Franke, L, van Vugt, M A T M

“…Homologous recombination (HR) is required for faithful repair of double-strand DNA breaks. Defects in HR repair cause severe genomic instability and challenge…”
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Rectal and colon cancer: Not just a different anatomic site by Tamas, K, Walenkamp, A.M.E, de Vries, E.G.E, van Vugt, M.A.T.M, Beets-Tan, R.G, van Etten, B, de Groot, D.J.A, Hospers, G.A.P

“…Highlights • Neoadjuvant radiotherapy is administered only for rectal cancer. • There is a lack of robust evidence for adjuvant chemotherapy in rectal cancer…”
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Forced activation of Cdk1 via wee1 inhibition impairs homologous recombination by Krajewska, M, Heijink, A M, Bisselink, Y J W M, Seinstra, R I, Silljé, H H W, de Vries, E G E, van Vugt, M A T M

“…In response to DNA breaks, the ‘DNA damage response’ provokes a cell cycle arrest to facilitate DNA repair. Recent findings have indicated that cells can…”
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RIF1 promotes replication fork protection and efficient restart to maintain genome stability by Mukherjee, Chirantani, Tripathi, Vivek, Manolika, Eleni Maria, Heijink, Anne Margriet, Ricci, Giulia, Merzouk, Sarra, de Boer, H. Rudolf, Demmers, Jeroen, van Vugt, Marcel A. T. M., Ray Chaudhuri, Arnab

“…Homologous recombination (HR) and Fanconi Anemia (FA) pathway proteins in addition to their DNA repair functions, limit nuclease-mediated processing of stalled…”
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Targeting of β1 integrins impairs DNA repair for radiosensitization of head and neck cancer cells by Dickreuter, E, Eke, I, Krause, M, Borgmann, K, van Vugt, M A, Cordes, N

“…β1 Integrin-mediated cell–extracellular matrix interactions allow cancer cell survival and confer therapy resistance. It was shown that inhibition of β1…”
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An add-on training program involving breathing exercises, cold exposure, and meditation attenuates inflammation and disease activity in axial spondyloarthritis - A proof of concept trial by Buijze, G A, De Jong, H M Y, Kox, M, van de Sande, M G, Van Schaardenburg, D, Van Vugt, R M, Popa, C D, Pickkers, P, Baeten, D L P

“…The primary objective of this trial was to assess safety and anti-inflammatory effects of an add-on training program involving breathing exercises, cold…”
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Prime editing for functional repair in patient-derived disease models by Schene, Imre F., Joore, Indi P., Oka, Rurika, Mokry, Michal, van Vugt, Anke H. M., van Boxtel, Ruben, van der Doef, Hubert P. J., van der Laan, Luc J. W., Verstegen, Monique M. A., van Hasselt, Peter M., Nieuwenhuis, Edward E. S., Fuchs, Sabine A.

“…Prime editing is a recent genome editing technology using fusion proteins of Cas9-nickase and reverse transcriptase, that holds promise to correct the vast…”
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Identification and Validation of Esophageal Squamous Cell Carcinoma Targets for Fluorescence Molecular Endoscopy by Zhao, Xiaojuan, Huang, Qingfeng, Koller, Marjory, Linssen, Matthijs D, Hooghiemstra, Wouter T R, de Jongh, Steven J, van Vugt, Marcel A T M, Fehrmann, Rudolf S N, Li, Enmin, Nagengast, Wouter B

“…Dysplasia and intramucosal esophageal squamous cell carcinoma (ESCC) frequently go unnoticed with white-light endoscopy and, therefore, progress to invasive…”
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miR-371a-3p, miR-373-3p and miR-367-3p as Serum Biomarkers in Metastatic Testicular Germ Cell Cancers Before, During and After Chemotherapy by Rosas Plaza, Ximena, van Agthoven, Ton, Meijer, Coby, van Vugt, Marcel A T M, de Jong, Steven, Gietema, Jourik A, Looijenga, Leendert H J

“…LDH (lactate dehydrogenase), AFP (alpha-fetoprotein) and β-HCG (human chorionic gonadotropin) are used in diagnosis and follow-up of testicular germ cell…”
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A randomised controlled trial testing the efficacy of Fit after COVID, a cognitive behavioural therapy targeting severe post-infectious fatigue following COVID-19 (ReCOVer): study protocol by Kuut, T A, Müller, F, Aldenkamp, A, Assmann-Schuilwerve, E, Braamse, A, Geerlings, S E, Gibney, K B, Kanaan, R A A, Nieuwkerk, P, Olde Hartman, T C, Pauëlsen, D, Prins, M, Slieker, K, Van Vugt, M, Bleeker-Rovers, C P, Keijmel, S P, Knoop, H

“…Coronavirus disease 2019 (COVID-19) results in debilitating long-term symptoms, often referred to as Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), in a…”
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A mixed-methods evaluation of hepatitis B knowledge, attitudes, and practices among migrant women in Thailand by Bierhoff, M., Hashmi, A. H., Pateekhum, C., Jiraporncharoen, W., Wiwattanacharoen, W., Paw, MK, Nosten, F. H., Rijken, M. J., Van Vugt, M., McGready, R., Angkurawaranon, C.

“…Abstract Background Globally 90 % of transmission of Hepatitis B virus (HBV) is from mother-to child and occurs predominantly in resource limited countries…”
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BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity by Heijink, Anne Margriet, Talens, Francien, Jae, Lucas T., van Gijn, Stephanie E., Fehrmann, Rudolf S. N., Brummelkamp, Thijn R., van Vugt, Marcel A. T. M.

“…Loss of BRCA2 affects genome stability and is deleterious for cellular survival. Using a genome-wide genetic screen in near-haploid KBM-7 cells, we show that…”
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Molecular and Pharmacological Determinants of the Therapeutic Response to Artemether-Lumefantrine in Multidrug-Resistant Plasmodium falciparum Malaria by Price, Ric N., Uhlemann, Anne-Catrin, van Vugt, Michele, Brockman, Al, Hutagalung, Robert, Nair, Shalini, Nash, Denae, Singhasivanon, Pratap, Anderson, Tim J. C., Krishna, Sanjeev, White, Nicholas J., Nosten, François

“…Background. Our study examined the relative contributions of host, pharmacokinetic, and parasitological factors in determining the therapeutic response to…”
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Tenofovir for prevention of mother to child transmission of hepatitis B in migrant women in a resource-limited setting on the Thailand-Myanmar border: a commentary on challenges of implementation by Bierhoff, M, Rijken, M J, Yotyingaphiram, W, Pimanpanarak, M, van Vugt, M, Angkurawaranon, C, Nosten, F, Ehrhardt, S, Thio, C L, McGready, R

“…The aim of this manuscript is to highlight challenges in the implementation of maternal tenofovir disoproxil fumarate (tenofovir) for prevention of mother to…”
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Transcriptional effects of copy number alterations in a large set of human cancers by Bhattacharya, Arkajyoti, Bense, Rico D., Urzúa-Traslaviña, Carlos G., de Vries, Elisabeth G. E., van Vugt, Marcel A. T. M., Fehrmann, Rudolf S. N.

“…Copy number alterations (CNAs) can promote tumor progression by altering gene expression levels. Due to transcriptional adaptive mechanisms, however, CNAs do…”
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A randomized phase II study investigating the addition of the specific COX-2 inhibitor celecoxib to docetaxel plus carboplatin as first-line chemotherapy for stage IC to IV epithelial ovarian cancer, Fallopian tube or primary peritoneal carcinomas: the DoCaCel study by Reyners, A.K.L., de Munck, L., Erdkamp, F.L.G., Smit, W.M., Hoekman, K., Lalisang, R.I., de Graaf, H., Wymenga, A.N.M., Polee, M., Hollema, H., van Vugt, M.A.T.M., Schaapveld, M., Willemse, P.H.B.

“…In ovarian cancer, cyclooxygenase-2 (COX-2) overexpression is prognostic for poor survival. We investigated the efficacy of celecoxib (C), a selective COX-2…”
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Checkpoint kinase 2 (Chk2) supports sensitivity to platinum-based treatment in high grade serous ovarian cancer by Alkema, N.G, Tomar, T, van der Zee, A.G.J, Everts, M, Meersma, G.J, Hollema, H, de Jong, S, van Vugt, M.A.T.M, Wisman, G.B.A

“…Abstract Objective Platinum-based chemotherapy is the standard treatment in advanced stage high grade serous ovarian cancer (HGSOC), but the majority of…”
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Unravelling mechanisms of cisplatin sensitivity and resistance in testicular cancer by Koster, R, van Vugt, M A T M, Timmer-Bosscha, H, Gietema, J A, de Jong, S

“…Testicular cancer is the most frequent solid malignant tumour type in men 20-40 years of age. At the time of diagnosis up to 50% of the patients suffer from…”
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Sister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51 by Heijink, Anne Margriet, Stok, Colin, Porubsky, David, Manolika, Eleni Maria, de Kanter, Jurrian K., Kok, Yannick P., Everts, Marieke, de Boer, H. Rudolf, Audrey, Anastasia, Bakker, Femke J., Wierenga, Elles, Tijsterman, Marcel, Guryev, Victor, Spierings, Diana C. J., Knipscheer, Puck, van Boxtel, Ruben, Ray Chaudhuri, Arnab, Lansdorp, Peter M., van Vugt, Marcel A. T. M.

“…Sister chromatid exchanges (SCEs) are products of joint DNA molecule resolution, and are considered to form through homologous recombination (HR). Indeed, SCE…”
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The Fanconi anemia core complex promotes CtIP-dependent end resection to drive homologous recombination at DNA double-strand breaks by van de Kooij, Bert, van der Wal, Fenna J., Rother, Magdalena B., Wiegant, Wouter W., Creixell, Pau, Stout, Merula, Joughin, Brian A., Vornberger, Julia, Altmeyer, Matthias, van Vugt, Marcel A. T. M., Yaffe, Michael B., van Attikum, Haico

“…During the repair of interstrand crosslinks (ICLs) a DNA double-strand break (DSB) is generated. The Fanconi anemia (FA) core complex, which is recruited to…”
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