Search Results - "M. Valpuesta, Jose"

The architecture of the Schizosaccharomyces pombe CCR4-NOT complex by Ukleja, Marta, Cuellar, Jorge, Siwaszek, Aleksandra, Kasprzak, Joanna M., Czarnocki-Cieciura, Mariusz, Bujnicki, Janusz M., Dziembowski, Andrzej, M. Valpuesta, Jose

“…CCR4-NOT is a large protein complex present both in cytoplasm and the nucleus of eukaryotic cells. Although it is involved in a variety of distinct processes…”
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Increased Sensitivity of Antigen-Experienced T Cells through the Enrichment of Oligomeric T Cell Receptor Complexes by Kumar, Rashmi, Ferez, María, Swamy, Mahima, Arechaga, Ignacio, Rejas, María Teresa, Valpuesta, Jose M., Schamel, Wolfgang W.A., Alarcon, Balbino, van Santen, Hisse M.

“…Although memory T cells respond more vigorously to stimulation and they are more sensitive to low doses of antigen than naive T cells, the molecular basis of…”
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Structure of the Hsp110:Hsc70 Nucleotide Exchange Machine by Schuermann, Jonathan P., Jiang, Jianwen, Cuellar, Jorge, Llorca, Oscar, Wang, Liping, Gimenez, Luis E., Jin, Suping, Taylor, Alexander B., Demeler, Borries, Morano, Kevin A., Hart, P. John, Valpuesta, Jose M., Lafer, Eileen M., Sousa, Rui

“…Hsp70s mediate protein folding, translocation, and macromolecular complex remodeling reactions. Their activities are regulated by proteins that exchange ADP…”
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Expression, Functional Characterization, and Preliminary Crystallization of the Cochaperone Prefoldin from the Thermophilic Fungus Chaetomium thermophilum by Morita, Kento, Yamamoto, Yohei Y, Hori, Ayaka, Obata, Tomohiro, Uno, Yuko, Shinohara, Kyosuke, Noguchi, Keiichi, Noi, Kentaro, Ogura, Teru, Ishii, Kentaro, Kato, Koichi, Kikumoto, Mahito, Arranz, Rocio, Valpuesta, Jose M, Yohda, Masafumi

“…Prefoldin is a hexameric molecular chaperone found in the cytosol of archaea and eukaryotes. Its hexameric complex is built from two related classes of…”
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Prefoldin 5 Is Required for Normal Sensory and Neuronal Development in a Murine Model by Lee, YongSuk, Smith, Richard S., Jordan, Wanda, King, Benjamin L., Won, Jungyeon, Valpuesta, Jose M., Naggert, Jurgen K., Nishina, Patsy M.

“…Molecular chaperones and co-chaperones are crucial for cellular development and maintenance as they assist in protein folding and stabilization of unfolded or…”
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Structure and non-structure of centrosomal proteins by Dos Santos, Helena G, Abia, David, Janowski, Robert, Mortuza, Gulnahar, Bertero, Michela G, Boutin, Maïlys, Guarín, Nayibe, Méndez-Giraldez, Raúl, Nuñez, Alfonso, Pedrero, Juan G, Redondo, Pilar, Sanz, María, Speroni, Silvia, Teichert, Florian, Bruix, Marta, Carazo, José M, Gonzalez, Cayetano, Reina, José, Valpuesta, José M, Vernos, Isabelle, Zabala, Juan C, Montoya, Guillermo, Coll, Miquel, Bastolla, Ugo, Serrano, Luis

“…Here we perform a large-scale study of the structural properties and the expression of proteins that constitute the human Centrosome. Centrosomal proteins tend…”
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The Structure of Native Influenza Virion Ribonucleoproteins by Arranz, Rocío, Coloma, Rocío, Chichón, Francisco Javier, Conesa, José Javier, Carrascosa, José L., Valpuesta, José M., Ortín, Juan, Martín-Benito, Jaime

“…The influenza viruses cause annual epidemics of respiratory disease and occasional pandemics, which constitute a major public-health issue. The segmented…”
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Clathrin-coat disassembly illuminates the mechanisms of Hsp70 force generation by Sousa, Rui, Liao, Hsien-Shun, Cuéllar, Jorge, Jin, Suping, Valpuesta, José M, Jin, Albert J, Lafer, Eileen M

“…Light-scattering kinetics and atomic force and electron microscopy analyses show that Hsp70-mediated disassembly of clathrin cages occurs via a…”
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Mechanical Identities of RNA and DNA Double Helices Unveiled at the Single-Molecule Level by Herrero-Galán, Elías, Fuentes-Perez, Maria Eugenia, Carrasco, Carolina, Valpuesta, José M, Carrascosa, José L, Moreno-Herrero, Fernando, Arias-Gonzalez, J. Ricardo

“…Double-stranded (ds) RNA is the genetic material of a variety of viruses and has been recently recognized as a relevant molecule in cells for its regulatory…”
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Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation by Bueno-Carrasco, María Teresa, Cuéllar, Jorge, Flydal, Marte I., Santiago, César, Kråkenes, Trond-André, Kleppe, Rune, López-Blanco, José R., Marcilla, Miguel, Teigen, Knut, Alvira, Sara, Chacón, Pablo, Martinez, Aurora, Valpuesta, José M.

“…Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of dopamine (DA) and other catecholamines, and its dysfunction leads to DA…”
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The structure of a biologically active influenza virus ribonucleoprotein complex by Coloma, Rocío, Valpuesta, José M, Arranz, Rocío, Carrascosa, José L, Ortín, Juan, Martín-Benito, Jaime

“…The influenza viruses contain a segmented, single-stranded RNA genome of negative polarity. Each RNA segment is encapsidated by the nucleoprotein and the…”
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Structural characterization of the substrate transfer mechanism in Hsp70/Hsp90 folding machinery mediated by Hop by Alvira, Sara, Cuéllar, Jorge, Röhl, Alina, Yamamoto, Soh, Itoh, Hideaki, Alfonso, Carlos, Rivas, Germán, Buchner, Johannes, Valpuesta, José M.

“…In eukarya, chaperones Hsp70 and Hsp90 act coordinately in the folding and maturation of a range of key proteins with the help of several co-chaperones,…”
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Structural and functional analysis of the role of the chaperonin CCT in mTOR complex assembly by Cuéllar, Jorge, Ludlam, W. Grant, Tensmeyer, Nicole C., Aoba, Takuma, Dhavale, Madhura, Santiago, César, Bueno-Carrasco, M. Teresa, Mann, Michael J., Plimpton, Rebecca L., Makaju, Aman, Franklin, Sarah, Willardson, Barry M., Valpuesta, José M.

“…The mechanistic target of rapamycin (mTOR) kinase forms two multi-protein signaling complexes, mTORC1 and mTORC2, which are master regulators of cell growth,…”
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High resolution atomic force microscopy of double-stranded RNA by Ares, Pablo, Fuentes-Perez, Maria Eugenia, Herrero-Galán, Elías, Valpuesta, José M, Gil, Adriana, Gomez-Herrero, Julio, Moreno-Herrero, Fernando

“…Double-stranded (ds) RNA mediates the suppression of specific gene expression, it is the genetic material of a number of viruses, and a key activator of the…”
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Chaperonins: two rings for folding by Yébenes, Hugo, Mesa, Pablo, Muñoz, Inés G., Montoya, Guillermo, Valpuesta, José M.

“…Chaperonins are ubiquitous chaperones found in Eubacteria, eukaryotic organelles (group I), Archaea and the eukaryotic cytosol (group II). They all share a…”
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Arc self‐association and formation of virus‐like capsids are mediated by an N‐terminal helical coil motif by Eriksen, Maria S., Nikolaienko, Oleksii, Hallin, Erik I., Grødem, Sverre, Bustad, Helene J., Flydal, Marte I., Merski, Ian, Hosokawa, Tomohisa, Lascu, Daniela, Akerkar, Shreeram, Cuéllar, Jorge, Chambers, James J., O’Connell, Rory, Muruganandam, Gopinath, Loris, Remy, Touma, Christine, Kanhema, Tambudzai, Hayashi, Yasunori, Stratton, Margaret M., Valpuesta, José M., Kursula, Petri, Martinez, Aurora, Bramham, Clive R.

“…Arc is a protein involved in neuronal plasticity, with the remarkable ability to assemble into virus‐like capsid structures. We have identified a coil…”
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Elevated levels of Secreted-Frizzled-Related-Protein 1 contribute to Alzheimer’s disease pathogenesis by Esteve, Pilar, Rueda-Carrasco, Javier, Inés Mateo, María, Martin-Bermejo, María Jesús, Draffin, Jonathan, Pereyra, Guadalupe, Sandonís, África, Crespo, Inmaculada, Moreno, Inmaculada, Aso, Ester, Garcia-Esparcia, Paula, Gomez-Tortosa, Estrella, Rábano, Alberto, Fortea, Juan, Alcolea, Daniel, Lleo, Alberto, Heneka, Michael T., Valpuesta, José M., Esteban, José A., Ferrer, Isidro, Domínguez, Mercedes, Bovolenta, Paola

“…The deposition of aggregated amyloid-β peptides derived from the pro-amyloidogenic processing of the amyloid precurson protein (APP) into characteristic…”
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Engineering protein assemblies with allosteric control via monomer fold-switching by Campos, Luis A., Sharma, Rajendra, Alvira, Sara, Ruiz, Federico M., Ibarra-Molero, Beatriz, Sadqi, Mourad, Alfonso, Carlos, Rivas, Germán, Sanchez-Ruiz, Jose M., Romero Garrido, Antonio, Valpuesta, José M., Muñoz, Victor

“…The macromolecular machines of life use allosteric control to self-assemble, dissociate and change shape in response to signals. Despite enormous interest, the…”
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Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin by Valpuesta, José M, Montoya, Guillermo, Muñoz, Inés G, Yébenes, Hugo, Zhou, Min, Mesa, Pablo, Serna, Marina, Park, Ah Young, Bragado-Nilsson, Elisabeth, Beloso, Ana, de Cárcer, Guillermo, Malumbres, Marcos, Robinson, Carol V

“…CCT/TRiC is a eukaryotic multi-subunit chaperonin that promotes the correct folding of many cytosolic proteins, including tubulin, within its cavity. Now the…”
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Truncation-Driven Lateral Association of α-Synuclein Hinders Amyloid Clearance by the Hsp70-Based Disaggregase by Franco, Aitor, Cuéllar, Jorge, Fernández-Higuero, José Ángel, de la Arada, Igor, Orozco, Natalia, Valpuesta, José M, Prado, Adelina, Muga, Arturo

“…The aggregation of α-synuclein is the hallmark of a collective of neurodegenerative disorders known as synucleinopathies. The tendency to aggregate of this…”
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