Search Results - "M. Slingerland"

Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Picon‐Ruiz, Manuel, Morata‐Tarifa, Cynthia, Valle‐Goffin, Janeiro J., Friedman, Eitan R., Slingerland, Joyce M.

“…Answer questions and earn CME/CNE Recent decades have seen an unprecedented rise in obesity, and the health impact thereof is increasingly evident. In 2014,…”
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Cytokines, Obesity, and Cancer: New Insights on Mechanisms Linking Obesity to Cancer Risk and Progression by Gilbert, Candace A, Slingerland, Joyce M

“…Obesity is a problem of epidemic proportions in many developed nations. Increased body mass index and obesity are associated with a significantly worse outcome…”
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Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy by Wander, Seth A, Hennessy, Bryan T, Slingerland, Joyce M

“…Mammalian target of rapamycin (mTOR) is a PI3K-related kinase that regulates cell growth, proliferation, and survival via mTOR complex 1 (mTORC1) and mTORC2…”
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The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy by Slingerland, Joyce M, Chu, Isabel M, Hengst, Ludger

“…Key Points p27 (also known as KIP1, and encoded by CDKN1B ) is regulated by multiple signal transduction pathways in normal and malignant cells. CDKN1B…”
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Multiple Roles of the PI3K/PKB (Akt) Pathway in Cell Cycle Progression by Liang, Jiyong, Slingerland, Joyce M.

“…As its role in tumor progression emerges, the PI3K/PKB (Akt) pathway presents an appealing cancer therapeutic target. Recent studies have investigated the…”
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Cardiac glycosides in cancer therapy: from preclinical investigations towards clinical trials by Slingerland, M., Cerella, C., Guchelaar, H. J., Diederich, M., Gelderblom, H.

“…Summary Cardiac glycosides have a long history in the treatment of cardiac disease. However, several preclinical studies as well as two phase I studies have…”
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p27: A Barometer of Signaling Deregulation and Potential Predictor of Response to Targeted Therapies by WANDER, Seth A, DEKUANG ZHAO, SLINGERLAND, Joyce M

“…Phosphorylation of the cyclin-dependent kinase inhibitor p27 by upstream mitogenic signaling pathways regulates its stability, localization, and biological…”
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Targeting of RAGE-ligand signaling impairs breast cancer cell invasion and metastasis by Kwak, T, Drews-Elger, K, Ergonul, A, Miller, P C, Braley, A, Hwang, G H, Zhao, D, Besser, A, Yamamoto, Y, Yamamoto, H, El-Ashry, D, Slingerland, J M, Lippman, M E, Hudson, B I

“…The receptor for advanced glycation end products (RAGE) is highly expressed in various cancers and is correlated with poorer outcome in breast and other…”
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Interactions between Adipocytes and Breast Cancer Cells Stimulate Cytokine Production and Drive Src/Sox2/miR-302b-Mediated Malignant Progression by Picon-Ruiz, Manuel, Pan, Chendong, Drews-Elger, Katherine, Jang, Kibeom, Besser, Alexandra H, Zhao, Dekuang, Morata-Tarifa, Cynthia, Kim, Minsoon, Ince, Tan A, Azzam, Diana J, Wander, Seth A, Wang, Bin, Ergonul, Burcu, Datar, Ram H, Cote, Richard J, Howard, Guy A, El-Ashry, Dorraya, Torné-Poyatos, Pablo, Marchal, Juan A, Slingerland, Joyce M

“…Consequences of the obesity epidemic on cancer morbidity and mortality are not fully appreciated. Obesity is a risk factor for many cancers, but the mechanisms…”
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p27 transcriptionally coregulates cJun to drive programs of tumor progression by Yoon, Hyunho, Kim, Minsoon, Jang, Kibeom, Shin, Miyoung, Besser, Alexandra, Xiao, Xue, Zhao, Dekuang, Wander, Seth A., Briegel, Karoline, Morey, Lluis, Minn, Andy, Slingerland, Joyce M.

“…p27 shifts from CDK inhibitor to oncogene when phosphorylated by PI3K effector kinases. Here, we show that p27 is a cJun coregulator, whose assembly and…”
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VEGFA activates an epigenetic pathway upregulating ovarian cancer‐initiating cells by Jang, Kibeom, Kim, Minsoon, Gilbert, Candace A, Simpkins, Fiona, Ince, Tan A, Slingerland, Joyce M

“…The angiogenic factor, VEGFA, is a therapeutic target in ovarian cancer (OVCA). VEGFA can also stimulate stem‐like cells in certain cancers, but mechanisms…”
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mTOR-Raptor Binds and Activates SGK1 to Regulate p27 Phosphorylation by Hong, Feng, Larrea, Michelle D., Doughty, Cheryl, Kwiatkowski, David J., Squillace, Rachel, Slingerland, Joyce M.

“…The cell-cycle effects of mTORC1 are not fully understood. We provide evidence that mTOR-raptor phosphorylates SGK1 to modulate p27 function. Cellular mTOR…”
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PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest by Slingerland, Joyce M, Liang, Jiyong, Zubovitz, Judit, Petrocelli, Teresa, Kotchetkov, Rouslan, Connor, Michael K, Han, Kathy, Lee, Jin-Hwa, Ciarallo, Sandra, Catzavelos, Charles, Beniston, Richard, Franssen, Edmee

“…Mechanisms linking mitogenic and growth inhibitory cytokine signaling and the cell cycle have not been fully elucidated in either cancer or in normal cells…”
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C-terminally phosphorylated p27 activates self-renewal driver genes to program cancer stem cell expansion, mammary hyperplasia and cancer by Razavipour, Seyedeh Fatemeh, Yoon, Hyunho, Jang, Kibeom, Kim, Minsoon, Nawara, Hend M., Bagheri, Amir, Huang, Wei-Chi, Shin, Miyoung, Zhao, Dekuang, Zhou, Zhiqun, Van Boven, Derek, Briegel, Karoline, Morey, Lluis, Ince, Tan A., Johnson, Michael, Slingerland, Joyce M.

“…In many cancers, a stem-like cell subpopulation mediates tumor initiation, dissemination and drug resistance. Here, we report that cancer stem cell (CSC)…”
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MAPK Activation Predicts Poor Outcome and the MEK Inhibitor, Selumetinib, Reverses Antiestrogen Resistance in ER-Positive High-Grade Serous Ovarian Cancer by Hew, Karina E, Miller, Philip C, El-Ashry, Dorraya, Sun, Jun, Besser, Alexandra H, Ince, Tan A, Gu, Mengnan, Wei, Zhi, Zhang, Gao, Brafford, Patricia, Gao, Wei, Lu, Yiling, Mills, Gordon B, Slingerland, Joyce M, Simpkins, Fiona

“…Although 67% of high-grade serous ovarian cancers (HGSOC) express the estrogen receptor (ER), most fail antiestrogen therapy. Because MAPK activation is…”
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Modelling greenhouse gas emissions of cacao production in the Republic of Côte d’Ivoire by Vervuurt, W., Slingerland, M. A., Pronk, A. A., Van Bussel, L. G. J.

“…The current expansion of cacao cultivation in the Republic of Côte d’Ivoire is associated with deforestation, forest degradation, biodiversity loss and high…”
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Prognostic value of patient-reported quality of life for survival in oesophagogastric cancer: analysis from the population-based POCOP study by van Kleef, J. J., Dijksterhuis, W. P. M., van den Boorn, H. G., Prins, M., Verhoeven, R. H. A., Gisbertz, S. S., Slingerland, M., Mohammad, N. Haj, Creemers, G.-J., Neelis, K. J., Heisterkamp, J., Rosman, C., Ruurda, J. P., Kouwenhoven, E. A., van de Poll-Franse, L. V., van Oijen, M. G. H., Sprangers, M. A. G., van Laarhoven, H. W. M.

“…Background Accumulating evidence of trials demonstrates that patient-reported health-related quality of life (HRQoL) at diagnosis is prognostic for overall…”
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Obtaining Human Breast Adipose Cells for Breast Cancer Cell Co-culture Studies by Picon-Ruiz, Manuel, Marchal, Juan A., Slingerland, Joyce M.

“…Primary human breast cancers invade surrounding fat and contact adipocytes, inflammatory infiltrates, and fibrous stroma. This tissue niche influences breast…”
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Long-Range Activation of GREB1 by Estrogen Receptor via Three Distal Consensus Estrogen-Responsive Elements in Breast Cancer Cells by Sun, Jun, Nawaz, Zafar, Slingerland, Joyce M

“…The estrogen receptor (ER) binds to estrogen-responsive elements (EREs) to activate gene transcription. The best characterized EREs are located in proximal…”
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A low-glucose eating pattern is associated with improvements in glycemic variability among women at risk for postmenopausal breast cancer: an exploratory analysis by Jospe, Michelle R, Liao, Yue, Giles, Erin D, Hudson, Barry I, Slingerland, Joyce M, Schembre, Susan M

“…High glycemic variability (GV) is a biomarker of cancer risk, even in the absence of diabetes. The emerging concept of chrononutrition suggests that modifying…”
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