Search Results - "M. Seccia, Teresa"
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The Biology of Normal Zona Glomerulosa and Aldosterone-Producing Adenoma: Pathological Implications
Published in Endocrine reviews (01-12-2018)“…Abstract The identification of several germline and somatic ion channel mutations in aldosterone-producing adenomas (APAs) and detection of cell clusters that…”
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ROCK (RhoA/Rho Kinase) in Cardiovascular-Renal Pathophysiology: A Review of New Advancements
Published in Journal of clinical medicine (02-05-2020)“…Rho-associated, coiled-coil containing kinases (ROCK) were originally identified as effectors of the RhoA small GTPase and found to belong to the AGC family of…”
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Angiotensin II Promotes SARS-CoV-2 Infection via Upregulation of ACE2 in Human Bronchial Cells
Published in International journal of molecular sciences (04-05-2022)“…Blockers of the renin-angiotensin system (RAS) have been reported to increase the angiotensin converting enzyme (ACE)2, the cellular receptor of SARS-CoV-2,…”
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Increased level of p63RhoGEF and RhoA/Rho kinase activity in hypertensive patients
Published in Journal of hypertension (01-02-2014)“…OBJECTIVE:p63RhoGEF, a guanine nucleotide exchange factor, has been reported ‘in vitro’ as key mediator of the angiotensin II-induced RhoA/Rho kinase…”
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Drug-resistant hypertension in primary aldosteronism patients undergoing adrenal vein sampling: the AVIS-2-RH study
Published in European journal of preventive cardiology (11-03-2022)“…We aimed at determining the rate of drug-resistant arterial hypertension in patients with an unambiguous diagnosis of primary aldosteronism (PA). Moreover, we…”
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Vascular Remodeling and Duration of Hypertension Predict Outcome of Adrenalectomy in Primary Aldosteronism Patients
Published in Hypertension (Dallas, Tex. 1979) (01-05-2008)“…Remodeling of the resistance arteries is a hallmark of arterial hypertension and predicts cardiovascular events, but it was unknown whether it could also…”
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Lower Expression of the TWIK-Related Acid-Sensitive K+ Channel 2 (TASK-2) Gene Is a Hallmark of Aldosterone-Producing Adenoma Causing Human Primary Aldosteronism
Published in The journal of clinical endocrinology and metabolism (01-04-2014)“…Context: The molecular mechanisms of primary aldosteronism, a common cause of human hypertension, are unknown, but alterations of K+ channels can play a key…”
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Management of hypertensive emergencies: a practical approach
Published in Blood pressure (04-07-2021)“…Background: Acute increases of high blood pressure values, usually described as ‘hypertensive crises’, ‘hypertensive urgencies’ or ‘hypertensive emergencies’,…”
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Review of Markers of Zona Glomerulosa and Aldosterone-Producing Adenoma Cells
Published in Hypertension (Dallas, Tex. 1979) (01-11-2017)Get full text
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Endothelin‐1 Drives Epithelial‐Mesenchymal Transition in Hypertensive Nephroangiosclerosis
Published in Journal of the American Heart Association (01-07-2016)“…Background Tubulointerstitial fibrosis, the final outcome of most kidney diseases, involves activation of epithelial mesenchymal transition (EMT). Endothelin‐1…”
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Somatic Mutations in the KCNJ5 Gene Raise the Lateralization Index: Implications for the Diagnosis of Primary Aldosteronism by Adrenal Vein Sampling
Published in The journal of clinical endocrinology and metabolism (01-12-2012)“…Context: Somatic mutations in the selectivity filter of KCNJ5 K+ channel were found to be associated with higher plasma aldosterone concentrations in the…”
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Hypertensive nephropathy. Moving from classic to emerging pathogenetic mechanisms
Published in Journal of hypertension (01-02-2017)“…Hypertensive kidney disease classically entails nephroangiosclerosis and hyalinosis with glomerular damage. However, in recent years, several evidences showed…”
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Clinical Management of Primary Aldosteronism: An Update
Published in Hypertension (Dallas, Tex. 1979) (01-09-2024)“…Despite carrying an excess risk of cardiovascular events, primary aldosteronism (PA) is a commonly overlooked secondary form of arterial hypertension. An…”
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Heterogeneity of Aldosterone-Producing Adenomas Revealed by a Whole Transcriptome Analysis
Published in Hypertension (Dallas, Tex. 1979) (01-12-2007)“…Aldosterone-producing adenomas (APAs) are a common cause of arterial hypertension, but the underlying molecular mechanisms are unknown, although a…”
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A Worrying and Puzzling Case of Hypertension Presenting to the Emergency Department
Published in Hypertension (Dallas, Tex. 1979) (01-06-2024)Get full text
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Chromogranin A Measurement for Assessing the Selectivity of Adrenal Venous Sampling in Primary Aldosteronism
Published in The journal of clinical endocrinology and metabolism (01-05-2011)“…Chromogranin A is tonically released by the adrenal gland, but it is not useful for assessing the selectivity of blood sampling during adrenal vein sampling…”
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Challenges in the evaluation of endothelial cell dysfunction: a statement from the European Society of Hypertension Working Group on Endothelin and Endothelial Factors
Published in Journal of hypertension (01-03-2023)“…Endothelial cell function is mediated by different mechanisms in different vascular beds. Moreover, in humans, endothelial cell dysfunction triggers and…”
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Aldosterone-producing adrenocortical carcinoma: an unusual cause of Conn’s syndrome with an ominous clinical course
Published in Endocrine-related cancer (01-03-2005)“…Aldosterone-producing adrenocortical carcinoma (APAC) is a rare cause of hypertension often diagnosed late because of paucity of information. Thus, we…”
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Role of estrogen receptors in modulating aldosterone biosynthesis and blood pressure
Published in Steroids (01-12-2019)“…Blood pressure is lower in premenopausal women than in age-matched men; after menopause blood pressure values and the prevalence of hypertension show opposite…”
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