Search Results - "M. P. Kirpichnikov"

Accumulation of β-Amyloid Leads to a Decrease in Lynx1 and Lypd6B Expression in the Hippocampus and Increased Expression of Proinflammatory Cytokines in the Hippocampus and Blood Serum by Bychkov, M. L., Kirichenko, A. V., Paramonov, A. S., Kirpichnikov, M. P., Lukmanova, E. N.

“…Alzheimer’s disease is a rapidly progressive neurodegenerative disease, the development of which is associated with the accumulation of β-amyloid oligomers,…”
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Optimization of recombinant antibody production based on the vector design and the level of metabolites for generation of Ig- producing stable cell lines by Toporova, V. A, Argentova, V. V, Aliev, T. K, Panina, A. A, Dolgikh, D. A, Kirpichnikov, M. P

“…Background The biopharmaceutical industry is significantly growing worldwide, and the Chinese hamster ovary (CHO) cells are used as a main expression host for…”
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Aspartate–Histidine Interaction in the Retinal Schiff Base Counterion of the Light-Driven Proton Pump of Exiguobacterium sibiricum by Balashov, S. P, Petrovskaya, L. E, Lukashev, E. P, Imasheva, E. S, Dioumaev, A. K, Wang, J. M, Sychev, S. V, Dolgikh, D. A, Rubin, A. B, Kirpichnikov, M. P, Lanyi, J. K

“…One of the distinctive features of eubacterial retinal-based proton pumps, proteorhodopsins, xanthorhodopsin, and others, is hydrogen bonding of the key…”
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PARP1 Inhibitors: antitumor drug design by Malyuchenko, N V, Kotova, E Yu, Kulaeva, O I, Kirpichnikov, M P, Studitskiy, V M

“…The poly (ADP-ribose) polymerase 1 (PARP1) enzyme is one of the promising molecular targets for the discovery of antitumor drugs. PARP1 is a common nuclear…”
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Nonselective Expression of Short-Wavelength Cone Opsin Improves Learning in Mice with Retinal Degeneration in a Visually Guided Task by Idzhilova, O. S., Kolotova, D. E., Smirnova, G. R., Abonakour, A., Dolgikh, D. A., Petrovskaya, L. E., Kirpichnikov, M. P., Ostrovsky, M. A., Malyshev, A. Yu

“…The study explored the potential of an animal opsin nonselectively expressed in various neuronal elements of the degenerative retina to restore the impaired…”
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Recombinant Analogue of the Human Protein SLURP-1 Inhibits the Growth of U251 MG and A172 Glioma Cells by Shulepko, M. A., Bychkov, M. L., Lyukmanova, E. N., Kirpichnikov, M. P.

“…The alpha7 nicotinic acetylcholine receptor (α7-nAChR) is considered a promising pharmacological target for the carcinoma therapy. We have previously shown…”
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Novel pH-Sensitive Microbial Rhodopsin from Sphingomonas paucimobilis by Maliar, N., Okhrimenko, I. S., Petrovskaya, L. E., Alekseev, A. A., Kovalev, K. V., Soloviov, D. V., Popov, P. A., Rokitskaya, T. I., Antonenko, Y. N., Zabelskii, D. V., Dolgikh, D. A., Kirpichnikov, M. P., Gordeliy, V. I.

“…This work provides the first characteristics of the rhodopsin SpaR from Sphingomonas paucimobilis , aerobic bacteria associated with opportunistic infections…”
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Recombinant Analogue of the Human Protein SLURP-1 Inhibits the Growth of Multicellular Spheroids Reconstructed from Carcinoma Cells by Bychkov, M. L., Shulepko, M. A., Shlepova, O. V., Lyukmanova, E. N., Kirpichnikov, M. P.

“…In the present study we showed that the recombinant analogue of the SLURP-1 protein effectively inhibits the growth of a 3D model of tumors—multicellular…”
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Characterization of an archaeal photoreceptor/transducer complex from Natronomonas pharaonis assembled within styrene-maleic acid lipid particles by Voskoboynikova, N, Mosslehy, W, Colbasevici, A, Ismagulova, T. T, Bagrov, D. V, Akovantseva, A. A, Timashev, P. S, Mulkidjanian, A. Y, Bagratashvili, V. N, Shaitan, K. V, Kirpichnikov, M. P, Steinhoff, H.-J

“…The styrene-maleic acid (SMA) copolymers enable a detergent-free extraction of membrane proteins from lipid bilayers yielding stable water-soluble…”
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Construction of Artificial TNF-Binding Proteins Based on the 10th Human Fibronectin Type III Domain Using Bacterial Display by Shingarova, L. N., Petrovskaya, L. E., Zlobinov, A. V., Gapizov, S. Sh, Kryukova, E. A., Birikh, K. R., Boldyreva, E. F., Yakimov, S. A., Dolgikh, D. A., Kirpichnikov, M. P.

“…Construction of antibody mimetics on the base of alternative scaffold proteins is a promising strategy for obtaining new products for medicine and…”
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Epitope Analysis of Murine and Chimeric Monoclonal Antibodies Recognizing the Cancer Testis Antigen PRAME by Misyurin, V. A., Finashutina, Yu. P., Turba, A. A., Larina, M. V., Solopova, O. N., Lyzhko, N. A., Kesaeva, L. A., Kasatkina, N. N., Aliev, T. K., Misyurin, A. V., Kirpichnikov, M. P.

“…We investigated the epitope specificity of different monoclonal antibodies recognizing the cancer testis antigen PRAME. Antibody 5D3 binds to the fragment of…”
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Selective targeting of α7 nicotinic acetylcholine receptor by synthetic peptide mimicking loop I of human SLURP-1 provides efficient and prolonged therapy of epidermoid carcinoma in vivo by Shlepova, O. V., Shulepko, M. A., Shipunova, V. O., Bychkov, M. L., Kukushkin, I. D., Chulina, I. A., Azev, V. N., Shramova, E. I., Kazakov, V. A., Ismailova, A. M., Palikova, Y. A., Palikov, V. A., Kalabina, E. A., Shaykhutdinova, E. A., Slashcheva, G. A., Tukhovskaya, E. A., Dyachenko, I. A., Murashev, A. N., Deyev, S. M., Kirpichnikov, M. P., Shenkarev, Z. O., Lyukmanova, E. N.

“…α7-Type nicotinic acetylcholine receptor (α7-nAChR) promotes the growth and metastasis of solid tumors. Secreted Ly6/uPAR-Related Protein 1 (SLURP-1) is a…”
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Monoclonal Antibodies to PRAME Protein Slow the Development of PRAME-Expressing Tumor by Solopova, O. N., Finashutina, Yu. P., Kasatkina, N. N., Lyzhko, N. A., Turba, A. A., Kesaeva, L. A., Misyurin, V. A., Misyurin, A. V., Larina, M. V., Aliev, T. K., Kirpichnikov, M. P.

“…Two monoclonal antibodies recognizing non-overlapping epitopes of the PRAME protein were injected into immunocompetent mice to study their influence on the…”
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Histone Tails Promote PARP1-Dependent Structural Rearrangements in Nucleosomes by Maluchenko, N. V., Sultanov, D. S., Kotova, E. Yu, Kirpichnikov, M. P., Studitsky, V. M., Feofanov, A. V.

“…PARP 1 alters the wrapping of nucleosomal DNA on the histone octamer, thereby modulating the accessibility of different genome sites to nuclear protein…”
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Recombinant Fragment of the Extracellular Domain of Human Desmoglein 3 Fused with the Fc-Fragment of Human IgG1 Selectively Adsorbs Autoreactive Antibodies from the Sera of Pemphigus Patients by Larina, E. N., Karasev, V. S., Shpilevaya, M. V., Aliev, T. K., Bochkova, O. P., Karamova, A. E., Balabashin, D. S., Deryabin, D. G., Bobik, T. V., Smirnov, I. V., Kubanov, A. A., Staroverov, S. M., Gabibov, A. G., Kirpichnikov, M. P.

“…Using the recombinant second fragment of the extracellular domain (EC2) of human desmoglein type 3 (Dsg3) as an affinity ligand, an immunosorbent was obtained…”
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Development of a Rapid Method for Monitoring Biodeterioration of Petroleum Products and Technical Fluids. Part I by Sandzhieva, D. A., Chudinova, E. M., Elansky, A. S., Elansky, S. N., Udovichenko, A. N., Burova, A. A., Kirpichnikov, M. P., Dedov, A. G.

“…Principles of a rapid method for monitoring biodeterioration of technical fluids were developed with metalworking fluids as examples. Physicochemical and…”
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Lipid-protein nanodiscs: Possible application in high-resolution NMR investigations of membrane proteins and membrane-active peptides by Shenkarev, Z. O, Lyukmanova, E. N, Solozhenkin, O. I, Gagnidze, I. E, Nekrasova, O. V, Chupin, V. V, Tagaev, A. A, Yakimenko, Z. A, Ovchinnikova, T. V, Kirpichnikov, M. P, Arseniev, A. S

“…High-resolution NMR is shown to be applicable for investigation of membrane proteins and membrane-active peptides embedded into lipid-protein nanodiscs (LPNs)…”
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Expression of G-protein coupled receptors in Escherichia coli for structural studies by Petrovskaya, L. E., Shulga, A. A., Bocharova, O. V., Ermolyuk, Ya. S., Kryukova, E. A., Chupin, V. V., Blommers, M. J. J., Arseniev, A. S., Kirpichnikov, M. P.

“…To elaborate a high-performance system for expression of genes of G-protein coupled receptors (GPCR), methods of direct and hybrid expression of 17 GPCR genes…”
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Overexpression in Escherichia coli and purification of human fibroblast growth factor (FGF-2) by Gasparian, M. E, Elistratov, P. A, Drize, N. I, Nifontova, I. N, Dolgikh, D. A, Kirpichnikov, M. P

“…Basic fibroblast growth factor (FGF-2) is a member of a large family of structurally related proteins that affect the growth, differentiation, migration, and…”
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Composite Scaffolds Containing Silk Fibroin, Gelatin, and Hydroxyapatite for Bone Tissue Regeneration and 3D Cell Culturing by Moisenovich, M M, Arkhipova, A Yu, Orlova, A A, Drutskaya, M S, Volkova, S V, Zacharov, S E, Agapov, I I, Kirpichnikov, M P

“…Three-dimensional (3D) silk fibroin scaffolds were modified with one of the major bone tissue derivatives (nano-hydroxyapatite) and/or a collagen derivative…”
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