Search Results - "M. Nielsen, Hanne"

Property profiling of biosimilar mucus in a novel mucus-containing in vitro model for assessment of intestinal drug absorption by Boegh, Marie, Baldursdóttir, Stefania G., Müllertz, Anette, Nielsen, Hanne M.

“…[Display omitted] Oral delivery of drugs, including peptide and protein therapeutics, can be impeded by the presence of the mucus surface-lining the intestinal…”
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Lipid Shell-Enveloped Polymeric Nanoparticles with High Integrity of Lipid Shells Improve Mucus Penetration and Interaction with Cystic Fibrosis-Related Bacterial Biofilms by Wan, Feng, Nylander, Tommy, Klodzinska, Sylvia Natalie, Foged, Camilla, Yang, Mingshi, Baldursdottir, Stefania G, M. Nielsen, Hanne

“…Nanoparticle (NP) mediated drug delivery into viscous biomatrices, e.g., mucus and bacterial biofilms, is challenging. Lipid shell-enveloped polymeric NPs…”
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Delineation of target volumes and organs at risk in adjuvant radiotherapy of early breast cancer: national guidelines and contouring atlas by the Danish Breast Cancer Cooperative Group by Nielsen, Mette H, Berg, Martin, Pedersen, Anders N, Andersen, Karen, Glavicic, Vladimir, Jakobsen, Erik H, Jensen, Ingelise, Josipovic, Mirjana, Lorenzen, Ebbe L, Nielsen, Hanne M, Stenbygaard, Lars, Thomsen, Mette S, Vallentin, Susanne, Zimmermann, Sune, Offersen, Birgitte V

“…During the past decade planning of adjuvant radiotherapy (RT) of early breast cancer has changed from two-dimensional (2D) to 3D conformal techniques. In the…”
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Social genetic effects for growth in pigs differ between boars and gilts by Nielsen, Hanne M, Ask, Birgitte, Madsen, Per

“…Average daily gain (ADG) in pigs is affected by the so-called social (or indirect) genetic effects (SGE). However, SGE may differ between sexes because boars…”
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Study of Failure Pattern Among High-Risk Breast Cancer Patients With or Without Postmastectomy Radiotherapy in Addition to Adjuvant Systemic Therapy: Long-Term Results From the Danish Breast Cancer Cooperative Group DBCG 82 b and c Randomized Studies by NIELSEN, Hanne M, OVERGAARD, Marie, GRAU, Cai, JENSEN, Anni R, OVERGAARD, Jens

“…Postmastectomy radiotherapy (RT) in high-risk breast cancer patients can reduce locoregional recurrences (LRRs) and improve disease-free and overall survival…”
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Antimicrobial Activity of α-Peptide/β-Peptoid Lysine-Based Peptidomimetics Against Colistin-Resistant Pseudomonas aeruginosa Isolated From Cystic Fibrosis Patients by Molchanova, Natalia, Wang, Hengzhuang, Hansen, Paul R, Høiby, Niels, Nielsen, Hanne M, Franzyk, Henrik

“…infection is a predominant cause of morbidity and mortality in patients with cystic fibrosis infection and with a compromised immune system. Emergence of…”
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Cell-Penetrating Antimicrobial Peptides – Prospectives for Targeting Intracellular Infections by Bahnsen, Jesper S., Franzyk, Henrik, Sayers, Edward J., Jones, Arwyn T., Nielsen, Hanne M.

“…ABSTRACT Purpose To investigate the suitability of three antimicrobial peptides (AMPs) as cell-penetrating antimicrobial peptides. Methods Cellular uptake of…”
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Prediction of genetic merit for growth rate in pigs using animal models with indirect genetic effects and genomic information by Poulsen, Bjarke G, Ask, Birgitte, Nielsen, Hanne M, Ostersen, Tage, Christensen, Ole F

“…Several studies have found that the growth rate of a pig is influenced by the genetics of the group members (indirect genetic effects). Accounting for these…”
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The predictive ability of indirect genetic models is reduced when culled animals are omitted from the data by Ask, Birgitte, Christensen, Ole F, Heidaritabar, Marzieh, Madsen, Per, Nielsen, Hanne M

“…Physical removal of individuals from groups causes reductions in group sizes and changes in group composition, which may affect the predictive ability of…”
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Stereoisomer-Dependent Membrane Association and Capacity for Insulin Delivery Facilitated by Penetratin by Birch, Ditlev, Sayers, Edward J, Christensen, Malene V, Jones, Arwyn T, Franzyk, Henrik, Nielsen, Hanne M

“…Cell-penetrating peptides (CPPs), such as penetratin, are often investigated as drug delivery vectors and incorporating d-amino acids, rather than the natural…”
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Models with indirect genetic effects depending on group sizes: a simulation study assessing the precision of the estimates of the dilution parameter by Heidaritabar, Marzieh, Bijma, Piter, Janss, Luc, Bortoluzzi, Chiara, Nielsen, Hanne M, Madsen, Per, Ask, Birgitte, Christensen, Ole F

“…In settings with social interactions, the phenotype of an individual is affected by the direct genetic effect (DGE) of the individual itself and by indirect…”
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Delivery of Dermatan Sulfate from Polyelectrolyte Complex-Containing Alginate Composite Microspheres for Tissue Regeneration by Wen, Yanhong, Grøndahl, Lisbeth, Gallego, Monica R, Jorgensen, Lene, Møller, Eva H, Nielsen, Hanne M

“…Dermatan sulfate (DS) is a glycosaminoglycan (GAG) with a great potential as a new therapeutic agent in tissue engineering. The aim of the present study was to…”
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Loco-regional recurrence after mastectomy in high-risk breast cancer—risk and prognosis. An analysis of patients from the DBCG 82 b&c randomization trials by Nielsen, Hanne M., Overgaard, Marie, Grau, Cai, Jensen, Anni R., Overgaard, Jens

“…In the DBCG 82 b&c trials, 3083 patients with stages II and III breast cancer were randomised to receive post-mastectomy radiotherapy (RT) versus no RT in…”
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Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design by de Groot, Anne Marit, Thanki, Kaushik, Gangloff, Monique, Falkenberg, Emily, Zeng, Xianghui, van Bijnen, Djai C.J., van Eden, Willem, Franzyk, Henrik, Nielsen, Hanne M., Broere, Femke, Gay, Nick J., Foged, Camilla, Sijts, Alice J.A.M.

“…Therapeutics based on small interfering RNA (siRNA) have promising potential as antiviral and anti-inflammatory agents. To deliver siRNA across cell membranes…”
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Is the benefit of postmastectomy irradiation limited to patients with four or more positive nodes, as recommended in international consensus reports? A subgroup analysis of the DBCG 82 b&c randomized trials by Overgaard, Marie, Nielsen, Hanne M, Overgaard, Jens

“…Abstract Background and aim Numerous consensus reports recommend that postmastectomy radiotherapy (RT) in addition to systemic therapy is indicated in…”
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Hypofractionated Versus Standard Fractionated Radiotherapy in Patients With Early Breast Cancer or Ductal Carcinoma In Situ in a Randomized Phase III Trial: The DBCG HYPO Trial by Offersen, Birgitte V, Alsner, Jan, Nielsen, Hanne M, Jakobsen, Erik H, Nielsen, Mette H, Krause, Mechthild, Stenbygaard, Lars, Mjaaland, Ingvil, Schreiber, Andreas, Kasti, Unn-Miriam, Overgaard, Jens

“…Given the poor results using hypofractionated radiotherapy for early breast cancer, a dose of 50 Gy in 25 fractions (fr) has been the standard regimen used by…”
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A free-floating mucin layer to investigate the effect of the local microenvironment in lungs on mucin-nanoparticle interactions by Wan, Feng, Herzberg, Mikkel, Huang, Zheng, Hassenkam, Tue, Nielsen, Hanne M.

“…Respiratory tract mucus represents an important barrier for pulmonary drug delivery. Understanding of mucin-nanoparticle interactions is a prerequisite for…”
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Utilizing nanoparticles for improving anti-biofilm effects of azithromycin: A head-to-head comparison of modified hyaluronic acid nanogels and coated poly (lactic-co-glycolic acid) nanoparticles by Kłodzińska, Sylvia N., Wan, Feng, Jumaa, Haidar, Sternberg, Claus, Rades, Thomas, Nielsen, Hanne M.

“…[Display omitted] The widespread resistance of bacteria to traditional antibiotic treatments has expedited the search for novel therapies against these…”
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Partial Breast Irradiation Versus Whole Breast Irradiation for Early Breast Cancer Patients in a Randomized Phase III Trial: The Danish Breast Cancer Group Partial Breast Irradiation Trial by Offersen, Birgitte V, Alsner, Jan, Nielsen, Hanne M, Jakobsen, Erik H, Nielsen, Mette H, Stenbygaard, Lars, Pedersen, Anders N, Thomsen, Mette S, Yates, Esben, Berg, Martin, Lorenzen, Ebbe L, Jensen, Ingelise, Josipovic, Mirjana, Jensen, Maj-Britt, Overgaard, Jens

“…On the basis of low risk of local recurrence in elderly patients with breast cancer after conservative surgery followed by whole breast irradiation (WBI), the…”
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Qualitative and quantitative analysis of the biophysical interaction of inhaled nanoparticles with pulmonary surfactant by using quartz crystal microbalance with dissipation monitoring by Wan, Feng, Nylander, Tommy, Foged, Camilla, Yang, Mingshi, Baldursdottir, Stefania G., Nielsen, Hanne M.

“…[Display omitted] Understanding the interaction between inhaled nanoparticles and pulmonary surfactant is a prerequisite for predicting the fate of inhaled…”
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