Search Results - "M. N. Repkova"

Therapeutic Nucleic Acids Against Herpes Simplex Viruses (A Review) by Levina, A. S., Repkova, M. N., Zarytova, V. F.

“…The Herpes simplex virus (HSV) causes a wide range of diseases ranging from relatively mild primary skin lesions to severe and often fatal episodes of…”
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Oligoribonucleotide-Containing Nanocomplexes Based on Aminopropylsilanol Nanoparticles as Effective Inhibitors of Influenza A Virus Replication by Repkova, M. N., Mazurkov, O. Yu, Filippova, E. I., Procenko, M. A., Mazurkova, N. A., Chelobanov, B. P., Levina, A. S., Zarytova, V. F.

“…Titanium dioxide or aminopropylsilanol nanoparticles were shown to be effective vehicles for delivering oligodeoxyribonucleotides and deoxyribozymes to cells…”
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Toward gene therapy of hypertension: Experimental study on hypertensive ISIAH rats by Repkova, M. N., Levina, A. S., Seryapina, A. A., Shikina, N. V., Bessudnova, E. V., Zarytova, V. F., Markel, A. L.

“…TiO 2 -based nanocomposites were prepared to deliver oligonucleotides into cells. The nanocomposites were designed by the immobilization of…”
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Antisense Oligonucleotides Immobilized on Silicon-Organic Nanoparticles as a Tool for Prolonged Correction of Hypertensive States by Levina, A. S., Repkova, M. N., Klimov, L. O., Ryazanova, M. A., Markel, A. L., Zarytova, V. F.

“…We propose an original method for controlling BP by administration of Si~ODN nanocomposites containing antisense oligonucleotides fixed on silicon-organic…”
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Methods of the Synthesis of Silicon-Containing Nanoparticles Intended for Nucleic Acid Delivery by A. S. Levina, M. N. Repkova, Z. R. Ismagilov, V. F. Zarytova

“…A promising new approach to the treatment of viral infections and genetic diseases associated with damaged or foreign nucleic acids in the body is gene…”
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Silencing of MDR 1 Gene in Cancer Cells by siRNA by Logashenko, E. B., Vladimirova, A. V., Repkova, M. N., Venyaminova, A. G., Chernolovskaya, E. L., Vlassov, V. V.

“…Inhibition of p-glycoprotein (PGP) expression and reverse of multidrug resistance (MDR) phenotype in KB-8-5 cells by synthetic 21-bp double-stranded…”
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Nuclear delivery of oligonucleotides via nanocomposites based on TiO2 nanoparticles and polylysine by Chelobanov, B. P., Repkova, M. N., Baiborodin, S. I., Ryabchikova, E. I., Stetsenko, D. A.

“…The nuclear delivery of nucleic acid derivatives is an essential prerequisite for successful antisense therapy. Using laser confocal and electron microscopy,…”
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The C domain of translation termination factor eRF1 is close to the stop codon in the A site of the 80S ribosome by Bulygin, K N, Popugaeva, E A, Repkova, M N, Meschaninova, MI, Ven'yaminova, A G, Graifer, D M, Frolova, LYu, Karpova, G G

“…The arrangement of the stop codon and its 3'-flanking codon relative to the components of translation termination complexes of human 80S ribosomes was studied…”
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Impact of delivery method on antiviral activity of phosphodiester, phosphorothioate, and phosphoryl guanidine oligonucleotides in MDCK cells infected with H5N1 bird flu virus by Levina, A. S., Repkova, M. N., Chelobanov, B. P., Bessudnova, E. V., Mazurkova, N. A., Stetsenko, D. A., Zarytova, V. F.

“…We have previously described nanocomposites containing conjugates or complexes of native oligodeoxyribonucleotides with poly-L-lysine and TiO 2 nanoparticles…”
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Polyclonal antibodies against a structure mimicking the covalent linkage unit between picornavirus RNA and VPg: an immunochemical study by Ivanova, O A, Venyaminova, A G, Repkova, M N, Drygin, Yu F

“…We propose that therapy of patients with anticancer drugs that poison DNA topoisomerases induces formation of covalent complexes of cellular RNAs and DNA…”
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Two-Component 10-23 DNA Enzymes by Fokina, A. A., Kuznetsova, M. A., Repkova, M. N., Venyaminova, A. G.

“…A new strategy for engineering of catalytic two-component constructions based on 10-23 DNAzyme was proposed. The using of a combination of shortened DNAzyme…”
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Eficient inhibition of human influenza A virus by oligonucleotides electrostatically fixed on polylysine-containing TiO2 nanoparticles by Levina, A S, Repkova, M N, Ismagilov, Z R, Shikina, N V, Mazurkova, N A, Zarytova, V F

“…Antiviral activity of TiO2 * PL * DNA nanobiocomposites was studied on the MDCK cell culture infected with influenza A virus (subtype H3N2). DNA fragments in…”
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Reversion of the multiple-drug resistance phenotype mediated by short interfering RNAs by Logashenko, E. B., Vladimirova, A. V., Zenkov, A. N., Repkova, M. N., Ven'yaminova, A. G., Chernolovskaya, E. L., Vlassov, V. V.

“…Repression of MDR1 gene expression and restoration of cancer cell sensitivity to cytostatic agents were studied with the use of synthetic siRNAs directed to…”
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Design of TiO2~DNA nanocomposites for penetration into cells by Levina, A. S., Ismagilov, Z. R., Repkova, M. N., Shikina, N. V., Baiborodin, S. I., Shatskaya, N. V., Zagrebelnyi, S. N., Zarytova, V. F.

“…Methods of noncovalent immobilization of DNA fragments on titanium dioxide nanoparticles (TiO 2 ) were developed to design TiO 2 ∼DNA nanocomposites, which…”
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The mRNA Codon Environment at the P and E Sites of Human Ribosomes Deduced from Photocrosslinking with pUUUGUU Derivatives by Demeshkina, N A, Laletina, E S, Meschaninova, M I, Repkova, M N, Ven'yaminova, A G, Graifer, D M, Karpova, G G

“…Three mRNA analogs--derivatives of hexaribonucleotide pUUUGUU comprising phenylalanine and valine codons with a perfluoroarylazido group attached to the C5…”
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Template Location on the Human Ribosome: Environment of the mRNA Nucleotide Adjacent to the A-Site Codon on the 3′-Side by Demeshkina, N. A., Styazhkina, V. A., Bulygin, K. N., Repkova, M. N., Ven’yaminova, A. G., Karpova, G. G.

“…The 18S rRNA nucleotides close to the template nucleotide adjacent to the 80S ribosomal A-site codon on the 3'-end (i.e., the nucleotide in position +7…”
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Protein Environment of the Sense Codon of the Template in the A Site of the Human Ribosome as Inferred from Crosslinking to Oligoribonucleotide Derivatives by Molotkov, M V, Graifer, D M, Meshchaninova, MI, Repkova, M N, Ven'yaminova, A G, Karpova, G G

“…The protein environment of each nucleotide of the template codon located in the A site of the human ribosome was studied with UUCUCAA and UUUGUU derivatives…”
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Design of deoxyribozymes for inhibition of influenza a virus reproduction by Evdokimov, A. A., Mazurkova, N. A., Malygin, E. G., Zarytova, V. F., Levina, A. S., Repkova, M. N., Zagrebelnyi, S. N., Netesova, N. A.

“…Influenza A viruses play a significant role in human and animal pathologies that cause epidemics and epizootics. Therefore, the development of new anti-flu…”
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The solution structure of a 3′-phenazinium (Pzn) tethered DNA-RNA duplex with a dangling adenosine: r(5′G-AUUGAA3′):d(5TCAATC3′ - Pzn) by Maltseva, T.V., Agback, P., Repkova, M.N., Venyaminova, A.G., Ivanova, E.M., Sandström, A., Zarytova, V.F., Chattopadhyaya, J.

“…The 3'-Pzn group tethered to an oligo-DNA stabilizes a DNA-RNA hybrid duplex structure by 13°C compared to the natural counterpart. This report constitutes the…”
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The First Nucleotide of the Codon Located in the P Site of the 80S Ribosome Is Close to G1702 of the 18S rRNA as Revealed by Crosslinking to a pUUUGUU Derivative Containing a Perfluorophenylazido Group at the Guanine by Demeshkina, NA, Repkova, M N, Ven'yaminova, A G, Graifer, D M, Karpova, G G

“…Modification of the 18S rRNA with a pUUUGUU derivative carrying a perfluorophenylazido group at N7 of G was studied in the complex with the human 80S ribosome…”
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