Search Results - "M. José Gómez-Lechón"

FLUORESCENCE-BASED ASSAYS FOR SCREENING NINE CYTOCHROME P450 (P450) ACTIVITIES IN INTACT CELLS EXPRESSING INDIVIDUAL HUMAN P450 ENZYMES by Donato, M Teresa, Jiménez, Nuria, Castell, José V, Gómez-Lechón, M José

“…In this study we describe a battery of fluorescence assays for rapid measurement in intact cells of the activity of nine cytochromes P450 (P450s) involved in…”
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Potential Impact of Steatosis on Cytochrome P450 Enzymes of Human Hepatocytes Isolated from Fatty Liver Grafts by DONATO, M. Teresa, LAHOZ, Agustin, JIMENEZ, Nuria, PEREZ, Gabriela, SERRALTA, Alfonso, MIR, José, CASTELL, José V, GOMEZ-LECHON, M. José

“…Liver grafts discarded for transplantation because of macrosteatosis can constitute a valuable source of human hepatocytes for in vitro metabolic and…”
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ATF5 Is a Highly Abundant Liver-Enriched Transcription Factor that Cooperates with Constitutive Androstane Receptor in the Transactivation of CYP2B6: Implications in Hepatic Stress Responses by PASCUAL, Maya, GOMEZ-LECHON, M. Jose, CASTELL, José V, JOVER, Ramiro

“…Activating transcription factor (ATF) 5 is a member of the ATF/cAMP response element-binding protein family, which has been associated with differentiation,…”
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Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity by Bort, R, Ponsoda, X, Jover, R, Gómez-Lechón, M J, Castell, J V

“…Diclofenac, a 2-arylacetic acid, nonsteroidal anti-inflammatory drug, has been reported to cause adverse hepatic effects in certain individuals. To…”
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Underexpressed Coactivators PGC1α AND SRC1 Impair Hepatocyte Nuclear Factor 4α Function and Promote Dedifferentiation in Human Hepatoma Cells by Celia P. Martínez-Jiménez, M. José Gómez-Lechón, José V. Castell, Ramiro Jover

“…Hepatocyte nuclear factor 4α (HNF4α) plays critical roles during liver development and in the transcriptional regulation of many hepatic genes in adult…”
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LIVER GRAFTS PRESERVED IN CELSIOR SOLUTION AS SOURCE OF HEPATOCYTES FOR DRUG METABOLISM STUDIES: COMPARISON WITH SURGICAL LIVER BIOPSIES by M. Teresa Donato, Alfonso Serralta, Nuria Jiménez, Gabriela Pérez, José V. Castell, José Mir, M. José Gómez-Lechón

“…Suitability of human liver grafts preserved in Celsior solution (CS) for preparing metabolically competent hepatocyte cultures has been examined. To this end,…”
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Human hepatocyte growth factor down-regulates the expression of cytochrome P450 isozymes in human hepatocytes in primary culture by Donato, M T, Gómez-Lechón, M J, Jover, R, Nakamura, T, Castell, J V

“…This study examines the effects of recombinant human hepatocyte growth factor (HGF), a potent mitogen for hepatocytes, on the cytochrome P450 (CYP) system and…”
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Oncostatin M down-regulates basal and induced cytochromes P450 in human hepatocytes by Guillén, M I, Donato, M T, Jover, R, Castell, J V, Fabra, R, Trullenque, R, Gómez-Lechón, M J

“…The effects of oncostatin M on the expression of different cytochrome P450 (CYP) isozymes has been investigated in human hepatocytes. The dose-response and…”
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