Search Results - "M. Gregor Madej"

Dawning of a new era in TRP channel structural biology by cryo-electron microscopy by Madej, M. Gregor, Ziegler, Christine M.

“…Cryo-electron microscopy (cryo-EM) permits the determination of atomic protein structures by averaging large numbers of individual projection images recorded…”
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Functional architecture of MFS d-glucose transporters by Madej, M Gregor, Sun, Linfeng, Yan, Nieng, Kaback, H Ronald

“…The Major Facilitator Superfamily (MFS) is a diverse group of secondary transporters with over 10,000 members, found in all kingdoms of life, including Homo…”
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Evolutionary mix-and-match with MFS transporters by Madej, M. Gregor, Dang, Shangyu, Yan, Nieng, Kaback, H. Ronald

“…Major facilitator superfamily (MFS) transport proteins are ubiquitous in the membranes of all living cells, and ∼25% of prokaryotic membrane transport proteins…”
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pH Regulation of Electrogenic Sugar/H+ Symport in MFS Sugar Permeases by Bazzone, Andre, Madej, M Gregor, Kaback, H Ronald, Fendler, Klaus

“…Bacterial sugar symporters in the Major Facilitator Superfamily (MFS) use the H+ (and in a few cases Na+) electrochemical gradients to achieve active transport…”
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A Loose Relationship: Incomplete H+/Sugar Coupling in the MFS Sugar Transporter GlcP by Bazzone, Andre, Zabadne, Annas J., Salisowski, Anastasia, Madej, M. Gregor, Fendler, Klaus

“…The glucose transporter from Staphylococcus epidermidis, GlcPSe, is a homolog of the human GLUT sugar transporters of the major facilitator superfamily…”
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Evolutionary mix-and-match with MFS transporters II by Madej, M Gregor, Kaback, H Ronald

“…One fundamentally important problem for understanding the mechanism of coupling between substrate and H ⁺ translocation with secondary active transport…”
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Apo-intermediate in the transport cycle of lactose permease (LacY) by Madej, M. Gregor, Soro, Sonya N, Kaback, H. Ronald

“…The lactose permease (LacY) catalyzes coupled stoichiometric symport of a galactoside and an H ⁺. Crystal structures reveal 12, mostly irregular, transmembrane…”
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Design, Synthesis, and Biological Testing of Novel Naphthoquinones as Substrate-Based Inhibitors of the Quinol/Fumarate Reductase from Wolinella succinogenes by Nasiri, Hamid Reza, Madej, M. Gregor, Panisch, Robin, Lafontaine, Michael, Bats, Jan W, Lancaster, C. Roy D, Schwalbe, Harald

“…Novel naphthoquinones were designed, synthesized, and tested as substrate-based inhibitors against the membrane-embedded protein quinol/fumarate reductase…”
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CopR, a Global Regulator of Transcription to Maintain Copper Homeostasis in Pyrococcus furiosus by Grünberger, Felix, Reichelt, Robert, Waege, Ingrid, Ned, Verena, Bronner, Korbinian, Kaljanac, Marcell, Weber, Nina, El Ahmad, Zubeir, Knauss, Lena, Madej, M Gregor, Ziegler, Christine, Grohmann, Dina, Hausner, Winfried

“…Although copper is in many cases an essential micronutrient for cellular life, higher concentrations are toxic. Therefore, all living cells have developed…”
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Substrate-induced changes in the structural properties of LacY by Serdiuk, Tetiana, Madej, M Gregor, Sugihara, Junichi, Kawamura, Shiho, Mari, Stefania A, Kaback, H Ronald, Müller, Daniel J

“…The lactose permease (LacY) of Escherichia coli , a paradigm for the major facilitator superfamily, catalyzes the coupled stoichiometric translocation of a…”
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The Vibrio vulnificus stressosome is an oxygen-sensor involved in regulating iron metabolism by Heinz, Veronika, Jäckel, Wenke, Kaltwasser, Susann, Cutugno, Laura, Bedrunka, Patricia, Graf, Anica, Reder, Alexander, Michalik, Stephan, Dhople, Vishnu M., Madej, M. Gregor, Conway, Maria, Lechner, Marcus, Riedel, Katharina, Bange, Gert, Boyd, Aoife, Völker, Uwe, Lewis, Richard J., Marles-Wright, Jon, Ziegler, Christine, Pané-Farré, Jan

“…Stressosomes are stress-sensing protein complexes widely conserved among bacteria. Although a role in the regulation of the general stress response is well…”
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Molecular insights into intra-complex signal transmission during stressosome activation by Miksys, Algirdas, Fu, Lifei, Madej, M. Gregor, Guerreiro, Duarte N., Kaltwasser, Susann, Conway, Maria, Ejder, Sema, Bruckmann, Astrid, Marles-Wright, Jon, Lewis, Richard J., O’Byrne, Conor, Pané-Farré, Jan, Ziegler, Christine

“…The stressosome is a pseudo-icosahedral megadalton bacterial stress-sensing protein complex consisting of several copies of two STAS-domain proteins, RsbR and…”
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Evidence for transmembrane proton transfer in a dihaem-containing membrane protein complex by Madej, M Gregor, Nasiri, Hamid R, Hilgendorff, Nicole S, Schwalbe, Harald, Lancaster, C Roy D

“…Membrane protein complexes can support both the generation and utilisation of a transmembrane electrochemical proton potential (‘proton‐motive force’), either…”
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Investigation of sugar binding kinetics of the E. coli sugar/H+ symporter XylE using solid-supported membrane-based electrophysiology by Bazzone, Andre, Tesmer, Laura, Kurt, Derya, Kaback, H. Ronald, Fendler, Klaus, Madej, M. Gregor

“…Bacterial transporters are difficult to study using conventional electrophysiology because of their low transport rates and the small size of bacterial cells…”
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Experimental Evidence for Proton Motive Force-Dependent Catalysis by the Diheme-Containing Succinate:Menaquinone Oxidoreductase from the Gram-Positive Bacterium Bacillus licheniformis by Madej, M. Gregor, Nasiri, Hamid R, Hilgendorff, Nicole S, Schwalbe, Harald, Unden, Gottfried, Lancaster, C. Roy D

“…In Gram-positive bacteria and other prokaryotes containing succinate:menaquinone reductases, it has previously been shown that the succinate oxidase and…”
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Molecular insights into lipid-assisted Ca 2+ regulation of the TRP channel Polycystin-2 by Wilkes, Martin, Madej, M Gregor, Kreuter, Lydia, Rhinow, Daniel, Heinz, Veronika, De Sanctis, Silvia, Ruppel, Sabine, Richter, Rebecca M, Joos, Friederike, Grieben, Marina, Pike, Ashley C W, Huiskonen, Juha T, Carpenter, Elisabeth P, Kühlbrandt, Werner, Witzgall, Ralph, Ziegler, Christine

“…Polycystin-2 (PC2), a calcium-activated cation TRP channel, is involved in diverse Ca signaling pathways. Malfunctioning Ca regulation in PC2 causes…”
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Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2 by Wilkes, Martin, Madej, M Gregor, Kreuter, Lydia, Rhinow, Daniel, Heinz, Veronika, De Sanctis, Silvia, Ruppel, Sabine, Richter, Rebecca M, Joos, Friederike, Grieben, Marina, Pike, Ashley C W, Huiskonen, Juha T, Carpenter, Elisabeth P, Kühlbrandt, Werner, Witzgall, Ralph, Ziegler, Christine

“…Cryo-EM structures of full-length human PC2 reveal two distinct channel states: an open conformation and a blocked conformation with Ca 2+ bound at the…”
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Transmembrane serine protease 2 (TMPRSS2) proteolytically activates the epithelial sodium channel (ENaC) by cleaving the channel’s γ-subunit by Sure, Florian, Bertog, Marko, Afonso, Sara, Diakov, Alexei, Rinke, Ralf, Madej, M. Gregor, Wittmann, Sabine, Gramberg, Thomas, Korbmacher, Christoph, Ilyaskin, Alexandr V.

“…The epithelial sodium channel (ENaC) is a heterotrimer consisting of α-, β-, and γ-subunits. Channel activation requires proteolytic release of inhibitory…”
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Comparative Sequence-Function Analysis of the Major Facilitator Superfamily: The "Mix-and-Match" Method by Madej, M Gregor

“…The major facilitator superfamily (MFS) is a diverse group of secondary transporters with members found in all kingdoms of life. The paradigm for MFS is the…”
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Orphan lysosomal solute carrier MFSD1 facilitates highly selective dipeptide transport by Boytsov, Danila, Madej, Gregor M, Horn, Georg, Blaha, Nadine, Köcher, Thomas, Sitte, Harald H, Siekhaus, Daria, Ziegler, Christine, Sandtner, Walter, Roblek, Marko

“…Orphan solute carrier (SLC) represents a group of membrane transporters whose exact functions and substrate specificities are not known. Elucidating the…”
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