Search Results - "M. Gotto, Antonio"

High-density lipoproteins, reverse cholesterol transport and atherogenesis by Pownall, Henry J., Rosales, Corina, Gillard, Baiba K., Gotto, Antonio M.

“…Plasma HDL-cholesterol concentrations correlate negatively with the risk of atherosclerotic cardiovascular disease (ASCVD). According to a widely cited model,…”
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Monocyte‐to‐HDL‐cholesterol ratio as a prognostic marker in cardiovascular diseases by Ganjali, Shiva, Gotto, Antonio M., Ruscica, Massimiliano, Atkin, Stephen L., Butler, Alexandra E., Banach, Maciej, Sahebkar, Amirhossein

“…Inflammation and lipid accumulation are two basic hallmarks of atherosclerosis as a chronic disease. Inflammation not only is a local response but can also be…”
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Biological Relevance of Inflammation and Oxidative Stress in the Pathogenesis of Arterial Diseases by Hajjar, David P, Gotto, Antonio M

“…Over the past three decades, age-adjusted rates of cardiovascular morbidity and mortality have fallen in the United States, but the prevalence of obesity and…”
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Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein by Ridker, Paul M, Danielson, Eleanor, Fonseca, Francisco A.H, Genest, Jacques, Gotto, Antonio M, Kastelein, John J.P, Koenig, Wolfgang, Libby, Peter, Lorenzatti, Alberto J, MacFadyen, Jean G, Nordestgaard, Børge G, Shepherd, James, Willerson, James T, Glynn, Robert J

“…In this trial, 17,802 healthy men and women with low-density lipoprotein cholesterol levels of less than 130 mg per deciliter and high-sensitivity C-reactive…”
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A Randomized Trial of Rosuvastatin in the Prevention of Venous Thromboembolism by Glynn, Robert J, Danielson, Eleanor, Fonseca, Francisco A.H, Genest, Jacques, Gotto, Antonio M, Kastelein, John J.P, Koenig, Wolfgang, Libby, Peter, Lorenzatti, Alberto J, MacFadyen, Jean G, Nordestgaard, Børge G, Shepherd, James, Willerson, James T, Ridker, Paul M

“…In this secondary analysis of data from JUPITER, rosuvastatin, as compared with placebo, resulted in a reduced risk of symptomatic venous thromboembolism…”
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HDL cholesterol and protective factors in atherosclerosis by Assmann, Gerd, Gotto, Jr, Antonio M

“…A low level of high-density lipoprotein cholesterol (HDL-C) is an important risk factor for cardiovascular disease. Epidemiological and clinical studies…”
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Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial by Ridker, Paul M, Prof, Dr, Danielson, Eleanor, MIA, Fonseca, Francisco AH, MD, Genest, Jacques, Prof, Gotto, Antonio M, Prof, Kastelein, John JP, Prof, Koenig, Wolfgang, Prof, Libby, Peter, Prof, Lorenzatti, Alberto J, Prof, MacFadyen, Jean G, BA, Nordestgaard, Børge G, Prof, Shepherd, James, Prof, Willerson, James T, Prof, Glynn, Robert J, ScD

“…Summary Background Statins lower high-sensitivity C-reactive protein (hsCRP) and cholesterol concentrations, and hypothesis generating analyses suggest that…”
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PCSK9 and inflammation: a review of experimental and clinical evidence by Momtazi-Borojeni, Amir Abbas, Sabouri-Rad, Sarvenaz, Gotto, Antonio M, Pirro, Matteo, Banach, Maciej, Awan, Zuhier, Barreto, George E, Sahebkar, Amirhossein

“…Abstract Proprotein convertase subtilisin/kexin Type 9 (PCSK9) is now identified as an important and major player in hypercholesterolaemia and atherosclerosis…”
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The pathophysiology of excess plasma-free cholesterol by Gillard, Baiba K, Rosales, Corina, Gotto, Jr, Antonio M, Pownall, Henry J

“…Several large studies have shown increased mortality due to all-causes and to atherosclerotic cardiovascular disease. In most clinical settings, plasma…”
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Serum opacity factor rescues fertility among female Scarb1−/− mice by reducing HDL-free cholesterol bioavailability by Rosales, Corina, Yelamanchili, Dedipya, Gillard, Baiba K., Liu, Jing, Gotto, Antonio M., Pownall, Henry J.

“…Human female infertility, 20% of which is idiopathic, is a public health problem for which better diagnostics and therapeutics are needed. A novel cause of…”
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Serum Opacity Factor Normalizes Erythrocyte Morphology in Scarb1-/- Mice in an HDL-Free Cholesterol-Dependent Way by Wang, Ziyi, Yelamanchili, Dedipya, Liu, Jing, Gotto, Antonio M., Rosales, Corina, Gillard, Baiba K., Pownall, Henry J.

“…Compared to wild-type (WT) mice, high-density lipoprotein (HDL)-receptor-deficient (Scarb1-/-) mice have higher plasma levels of free cholesterol (FC)-rich HDL…”
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Atherosclerosis risk classification with computed tomography angiography: A radiologic-pathologic validation study by Buckler, Andrew J., Gotto, Antonio M., Rajeev, Akshay, Nicolaou, Anna, Sakamoto, Atsushi, St Pierre, Samantha, Phillips, Matthew, Virmani, Renu, Villines, Todd C.

“…The application of machine learning to assess plaque risk phenotypes on cardiovascular CT angiography (CTA) is an area of active investigation. Studies using…”
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Statin Therapy and Outcome After Ischemic Stroke: Systematic Review and Meta-Analysis of Observational Studies and Randomized Trials by NI CHROININ, Danielle, ASPLUND, Kjell, GOTTO, Antonio M, HANNON, Niamh, JONSSON, Fredrik, KAPRAL, Moira K, MARTI-FABREGAS, Joan, MARTINEZ-SANCHEZ, Patricia, MILIONIS, Haralampos J, MONTANER, Joan, MUSCARI, Antonio, PIKIJA, Slaven, ASBERG, Signild, PROBSTFIELD, Jeffrey, ROST, Natalia S, THRIFT, Amanda G, VEMMOS, Konstantinos, KELLY, Peter J, CALLALY, Elizabeth, CUADRADO-GODIA, Elisa, DIEZ-TEJEDOR, Exuperio, DI NAPOLI, Mario, ENGELTER, Stefan T, FURIE, Karen L, GIANNOPOULOS, Sotirios

“…Although experimental data suggest that statin therapy may improve neurological outcome after acute cerebral ischemia, the results from clinical studies are…”
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ABCA1-Derived Nascent High-Density Lipoprotein-Apolipoprotein AI and Lipids Metabolically Segregate by Xu, Bingqing, Gillard, Baiba K, Gotto, Jr, Antonio M, Rosales, Corina, Pownall, Henry J

“…Reverse cholesterol transport comprises cholesterol efflux from ABCA1-expressing macrophages to apolipoprotein (apo) AI, giving nascent high-density…”
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Inflammation in atherosclerosis and implications for therapy by Paoletti, Rodolfo, Gotto, Jr, Antonio M, Hajjar, David P

“…Atherosclerosis is now understood to be a disease characterized by inflammation that results in a host of complications, including ischemia, acute coronary…”
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Management of Cardiovascular Risk: The Importance of Meeting Lipid Targets by Gotto, Antonio M., MD, DPhil, Moon, Jennifer E., PhD

“…Strategies to reduce cardiovascular risk in primary and secondary prevention focus on optimization of low-density lipoprotein (LDL) cholesterol levels. Since…”
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Benefits of Statins in Elderly Subjects Without Established Cardiovascular Disease: A Meta-Analysis by SAVARESE, Gianluigi, GOTTO, Antonio M, DE LUCA, Giuseppe, TRIMARCO, Bruno, PERRONE-FILARDI, Pasquale, PAOLILLO, Stefania, D'AMORE, Carmen, LOSCO, Teresa, MUSELLA, Francesca, SCALA, Oriana, MARCIANO, Caterina, RUGGIERO, Donatella, MARSICO, Fabio

“…The purpose of this paper was to assess whether statins reduce all-cause mortality and cardiovascular (CV) events in elderly people without established CV…”
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Comparing a novel machine learning method to the Friedewald formula and Martin-Hopkins equation for low-density lipoprotein estimation by Singh, Gurpreet, Hussain, Yasin, Xu, Zhuoran, Sholle, Evan, Michalak, Kelly, Dolan, Kristina, Lee, Benjamin C, van Rosendael, Alexander R, Fatima, Zahra, Peña, Jessica M, Wilson, Peter W F, Gotto, Jr, Antonio M, Shaw, Leslee J, Baskaran, Lohendran, Al'Aref, Subhi J

“…Low-density lipoprotein cholesterol (LDL-C) is a target for cardiovascular prevention. Contemporary equations for LDL-C estimation have limited accuracy in…”
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Statin Intolerance: the Clinician’s Perspective by Stulc, Tomáš, Ceška, Richard, Gotto, Antonio M.

“…Muscle problems and other adverse symptoms associated with statin use are frequent reasons for non-adherence and discontinuation of statin therapy, which…”
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Pharmacotherapies for lipid modification: beyond the statins by Gotto, Antonio M., Moon, Jennifer E.

“…Statins are the first-line therapy for the prevention and treatment of atherosclerotic vascular disease; however, various other lipid-lowering agents can…”
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