Search Results - "M. G. Yakubovskaya"

Structure, properties, and biological relevance of the DNA and RNA G-quadruplexes: Overview 50 years after their discovery by Dolinnaya, N. G., Ogloblina, A. M., Yakubovskaya, M. G.

“…G-quadruplexes (G4s), which are known to have important roles in regulation of key biological processes in both normal and pathological cells, are the most…”
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Antitumor effect of non-steroid glucocorticoid receptor ligand CpdA on leukemia cell lines CEM and K562 by Lesovaya, E. A., Yemelyanov, A. Yu, Kirsanov, K. I., Yakubovskaya, M. G., Budunova, I. V.

“…Glucocorticoids (GCs) are widely used in chemotherapy of hematological malignancies, particularly leukemia. Their effect is mediated by glucocorticoid receptor…”
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Preparation of Tritium Labeled Dexamethasone Phosphate and Its Application to Assess the Affinity of Ligands for Glucocorticoid Receptors by Badun, G. A., Zhidkova, E. M., Chernysheva, M. G., Enikeev, A. D., Yakubovskaya, M. G., Lesovaya, E. A.

“…The possibility of introducing tritium into dexamethasone and dexamethasone phosphate using the thermal activation method was demonstrated. The affinity of…”
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Molecular mechanisms of novel selective glucocorticoid receptor agonist action in breast cancer cells by Zhidkova, E. M., Maksimova, V. P., Grigoreva, D. D., Shirinian, V. Z., Yakubovskaya, M. G., Lesovaya, E. A.

“…Introduction . Glucocorticoids (GC) are widely used in breast cancer (BC) therapy to reduce the side effects of cytostatic drugs and may exhibit…”
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Alterations in WNT Signaling in Leukemias by Fetisov, T. I., Lesovaya, E. A., Yakubovskaya, M. G., Kirsanov, K. I., Belitsky, G. A.

“…The WNT/β–catenin signaling pathway plays an important role in the differentiation and proliferation of hematopoietic cells. In recent years, special attention…”
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Drug-Related Carcinogenesis: Risk Factors and Approaches for Its Prevention by Belitskiy, G. A., Kirsanov, K. I., Lesovaya, E. A., Yakubovskaya, M. G.

“…The review summarizes the data on the role of metabolic and repair systems in the mechanisms of therapy-related carcinogenesis and the effect of their…”
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Mechanisms of the carcinogenicity of nanomaterials by Belitsky, G. A., Kirsanov, K. I., Lesovaya, E. A., Yakubovskaya, M. G.

“…Nanomaterials become more widespread in the different areas of human life, forming the new technosphere philosophy, in particular, new approaches for…”
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Endocrine disruptors as promoters of biosphere carcinogenic background by Belitsky, G. A., Kirsanov, K. I., Lesovaya, E. A., Zhidkova, E. M., Khitrovo, I. A., Yakubovskaya, M. G.

“…The main aim of the study is to analyze modern knowledge on endocrine disruptors, non-genotoxic carcinogens, contributing significantly to the total level of…”
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Sexual dimorphism in cancer by Belitsky, G. A., Kirsanov, K. I., Lesovaya, E. A., Maksimova, V. P., Krivosheeva, L. V., Yakubovskaya, M. G.

“…The incidence and mortality of malignant neoplasms of non-reproductive organs both carcinomas and sarcomas in men is one and a half times higher than in women…”
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Two-faced Janus: on the 150th anniversary of the discovery of DDT by Morozova, O. V., Bukina, A. Yu, Popova, V. G., Khairieva, G. I., Sagitova, G. R., Belitsky, G. A., Yakubovskaya, M. G., Kirsanov, K. I., Maksimova, V. P.

“…One of the factors associated with increased morbidity of malignant neoplasms is environmental pollution with cancerogenic compounds including pesticides…”
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Approaches to anticancer therapy based on modulation of DNA methylation by Maksimova, V. P., Makus, J. V., Popova, V. G., Usalka, O. G., Belitsky, G. A., Yakubovskaya, M. G., Kirsanov, K. I.

“…Background . DNA methylation is a crucial mechanism of epigenetic regulation of transcription. Disturbances in DNA methylation mechanism are associated with…”
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Potential to use of viral reverse transcriptase inhibitors in oncology by Vlasova, O. A., Antonova, I. A., Magomedova, Kh. M., Usolkina, M. A., Kirsanov, K. I., Belitsky, G. A., Valiev, T. T., Yakubovskaya, M. G.

“…   In preparing the review, articles on the functioning of the reverse transcriptase enzyme of endogenous repeat sequences LINE1, the mechanisms of action and…”
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7-Methylguanine Inhibits Colon Cancer Growth in Vivo by Kirsanov, K I, Fetisov, T I, Antoshina, E E, Gor'kova, T G, Trukhanova, L S, Shram, S I, Nagaev, I Yu, Zolotarev, Yu A, Qoura, L Abo, Pokrovsky, V S, Yakubovskaya, M G, Švedas, V K, Nilov, D K

“…7-Methylguanine (7-MG) is a natural inhibitor of poly(ADP-ribose) polymerase 1 and tRNA-guanine transglycosylase, the enzymatic activity of which is central…”
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Autophagy activation in breast cancer cells in vitro after the treatment with PI3K/AKT/mTOR inhibitors by Grigoreva, D. D., Zhidkova, E. M., Lylova, E. S., Enikeev, A. D., Kirsanov, K. I., Belitsky, G. A., Yakubovskaya, M. G., Lesovaya, E. A.

“…Introduction . Current chemotherapy of breast cancer has a wide range of disadvantages, in particular, the development of therapy-related infections and…”
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Aberrations of DNA methylation in cancer by Maksimova, V. P., Usalka, O. G., Makus, Yu. V., Popova, V. G., Trapeznikova, E. S., Khayrieva, G. I., Sagitova, G. R., Zhidkova, E. M., Prus, A. Yu, Yakubovskaya, M. G., Kirsanov, K. I.

“…DNA methylation is a chromatin modification that plays an important role in the epigenetic regulation of gene expression. Changes in DNA methylation patterns…”
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Parallel G-quadruplexes formed by guanine-rich microsatellite repeats inhibit human topoisomerase I by Ogloblina, A. M., Bannikova, V. A., Khristich, A. N., Oretskaya, T. S., Yakubovskaya, M. G., Dolinnaya, N. G.

“…Using UV and CD spectroscopy, we studied the thermodynamic stability and folding topology of G-quadruplexes (G 4 ), formed by G-rich fragments in human…”
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In vitro screening of effectiveness and antiproliferative effects of potential ddit4 inhibitors for breast cancer cell lines by Zhidkova, E. M., Grigoreva, D. D., Lylova, E. S., Maksimova, V. P., Sagitova, G. R., Khayrieva, G. I., Trapeznikova, E. S., Kirsanov, K. I., Yakubovskaya, M. G., Lesovaya, E. A.

“…Objective: screening of previously selected DDIT4 inhibitors by their ability to suppress basal and glucocorticoid-induced expression of this gene in breast…”
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Inhibition of glucocorticoid-induced REDD1 expression by rapamycin in breast cancer cells by Grigorieva, D. D., Zhidkova, E. M., Lylova, E. S., Demina, D. V., Kirsanov, K. I., Belitsky, G. A., Yakubovskaya, M. G., Lesovaya, E. A.

“…Introduction. Glucocorticoids are often used in combination therapy for breast cancer as an adjuvant to increase therapeutic effects of the main cytotoxic drug…”
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Chemotherapy: some potential risks under antineoplastic drugs handling by Solenova, L. G., Yakubovskaya, M. G.

“…There is a large number of healthcare workers who may be exposed to anticancer drugs in different healthcare settings in Russia. Contamination of working…”
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METHODOLOGICAL APPROACHES TO THE DETERMINATION OF CHEMORESISTANCE OF HUMAN CANCER CELLS TO ANTI-CANCER DRUGS by Kirsanov, K. I., Kuzin, K. A., Fetisov, T. I., Lesovaya, E. A., Belitskiy, G. A., Yakubovskaya, M. G.

“…The purpose of the study was to analyze the existing methodological approaches to the experimental testing of resistance to chemotherapy and assess the…”
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