Search Results - "M. Dando"

Inhibition of Mammalian Legumain by Some Cystatins Is Due to a Novel Second Reactive Site by Alvarez-Fernandez, Marcia, Barrett, Alan J., Gerhartz, Bernd, Dando, Pam M., Ni, Jian, Abrahamson, Magnus

“…We have investigated the inhibition of the recently identified family C13 cysteine peptidase, pig legumain, by human cystatin C. The cystatin was seen to…”
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Aprepitant: A review of its use in the prevention of chemotherapy-induced nausea and vomiting by DANDO, Toni M, PERRY, Caroline M

“…Aprepitant (Emend) is the first commercially available drug from a new class of agents, the neurokinin NK(1) receptor antagonists. Oral aprepitant, in…”
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The optimal density of atmospheric sounder observations in the Met Office NWP system by Dando, M. L., Thorpe, A. J., Eyre, J. R.

“…Large numbers of satellite observations are discarded from the numerical weather prediction (NWP) process because high‐density observations may have a negative…”
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Cloning, Isolation, and Characterization of Mammalian Legumain, an Asparaginyl Endopeptidase by Chen, Jinq-May, Dando, Pam M., Rawlings, Neil D., Brown, Molly A., Young, Nina E., Stevens, Richard A., Hewitt, Eric, Watts, Colin, Barrett, Alan J.

“…Legumain is a cysteine endopeptidase that shows strict specificity for hydrolysis of asparaginyl bonds. The enzyme belongs to peptidase family C13, and is thus…”
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Adefovir dipivoxil: a review of its use in chronic hepatitis B by Dando, Toni, Plosker, Greg

“…Adefovir dipivoxil (Hepsera) is an oral prodrug of the nucleotide analogue adefovir. It is indicated for the treatment of chronic hepatitis B in adults…”
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The creation of a contagious H5N1 influenza virus: implications for the education of life scientists by T. Novossiolova, M. Minehata, M. Dando

“…The paper contends that the ongoing controversy surrounding the creation of a contagious H5N1 influenza virus has already exposed the severe limitations of the…”
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An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation by Watts, Colin, Manoury, Bénédicte, Hewitt, Eric W, Morrice, Nick, Dando, Pam M, Barrett, Alan J

“…Foreign protein antigens must be broken down within endosomes or lysosomes to generate suitable peptides that will form complexes with class II major…”
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Cloning and expression of mouse legumain, a lysosomal endopeptidase by Chen, J M, Dando, P M, Stevens, R A, Fortunato, M, Barrett, A J

“…Legumain, a recently discovered mammalian cysteine endopeptidase, was found in all mouse tissues examined, but was particularly abundant in kidney and…”
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Abacavir plus lamivudine. A review of their combined use in the management of HIV infection by DANDO, Toni M, SCOTT, Lesley J

“…Abacavir and lamivudine (two nucleoside analogue reverse transcriptase inhibitors [NRTIs]), as separate formulations in combination with other antiretroviral…”
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The impact of targeted satellite observations on numerical weather prediction by Dando, M. L., Thorpe, A. J., Eyre, J. R.

“…In numerical weather prediction (NWP), large quantities of satellite data are discarded because of operational time constraints and the potential for…”
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An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation by MANOURY, B, HEWITT, E. W, MORRICET, N, DANDO, P. M, BARRETT, A. J, WATTS, C

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Neuroethics beyond the laboratory door: The new state-level brain research projects and the problem of dual use by Dando, M.

“…A revolution is taking place in the life and associated sciences. Nowhere is this clearer than in neuroscience where a number of State-level brain research…”
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Quetiapine : A review of its use in acute mania and depression associated with bipolar disorder by DANDO, Toni M, KEATING, Gillian M

“…Quetiapine (Seroquel), an atypical antipsychotic with established efficacy in the treatment of schizophrenia, shows efficacy in the treatment of acute mania…”
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Emtricitabine/tenofovir disoproxil fumarate by Dando, Toni M, Wagstaff, Antona J

“…The nucleoside analogue reverse transcriptase inhibitor (RTI) emtricitabine and the nucleotide analogue RTI tenofovir disoproxil fumarate (tenofovir DF) have…”
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Legumain forms from plants and animals differ in their specificity by Rotari, V I, Dando, P M, Barrett, A J

“…We purified forms of legumain from a plant source (seeds of kidney bean, Phaseolus vulgaris) and a mammal (kidney of pig, Sus scropha) for comparison of their…”
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Low-dose ethinylestradiol/levonorgestrel by Dando, Toni M, Curran, Monique P

“…Low-dose ethinylestradiol/levonorgestrel 20 microg/100 microg is a combined oral contraceptive that prevents pregnancy primarily by inhibiting ovulation. The…”
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Topical tazarotene: a review of its use in the treatment of plaque psoriasis by Dando, Toni M, Wellington, Keri

“…Tazarotene (Tazorac) is a topical retinoid indicated for the treatment of plaque psoriasis. When used as monotherapy, topical tazarotene was effective at…”
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Enfuvirtide by Dando, Toni M, Perry, Caroline M

“…Enfuvirtide is the first of a new class of drugs, the fusion inhibitors. It is a synthetic peptide which binds to the HIV glycoprotein 41 (gp41), blocking…”
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Inhibition of mammalian legumain by Michael acceptors and AzaAsn-halomethylketones by Niestroj, André J, Feussner, Kirstin, Heiser, Ulrich, Dando, Pam M, Barrett, Alan, Gerhartz, Bernd, Demuth, Hans-Ulrich

“…Legumain is a lysosomal cysteine peptidase specific for an asparagine residue in the P1-position. It has been classified as a member of clan CD peptidases due…”
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Genomics and future biological weapons: the need for preventive action by the biomedical community by Fraser, Claire M, Dando, Malcolm R

“…There is an increasing concern within both the scientific and security communities that the ongoing revolution in biology has great potential to be misused in…”
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