Search Results - "M. Cosman"

Droplet Digital™ PCR quantitation of HER2 expression in FFPE breast cancer samples by Heredia, Nicholas J., Belgrader, Phillip, Wang, Shenglong, Koehler, Ryan, Regan, Jack, Cosman, Angela M., Saxonov, Serge, Hindson, Benjamin, Tanner, Stephanie C., Brown, Alexandra S., Karlin-Neumann, George

“…The human epidermal growth factor receptor 2 (HER2, also known as erbB2) gene is involved in signal transduction for cell growth and differentiation. It is a…”
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Reactive Uptake of N2O5 on Aqueous H2SO4 Solutions Coated with 1-Component and 2-Component Monolayers by Cosman, L. M, Bertram, A. K

“…Reactive uptake of N2O5 on aqueous sulfuric acid solutions was studied in the presence of 1-component (octadecanol) and 2-component (octadecanol + phytanic…”
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N2O5 Reactive Uptake on Aqueous Sulfuric Acid Solutions Coated with Branched and Straight-Chain Insoluble Organic Surfactants by Cosman, L. M, Knopf, D. A, Bertram, A. K

“…A flow reactor coupled to a chemical ionization mass spectrometer was used to study the reactive uptake coefficients at 273 K of N2O5 on aqueous 60 wt %…”
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Coilin participates in the suppression of RNA polymerase I in response to cisplatin-induced DNA damage by Gilder, Andrew S, Do, Phi M, Carrero, Zunamys I, Cosman, Angela M, Broome, Hanna J, Velma, Venkatramreddy, Martinez, Luis A, Hebert, Michael D

“…Coilin is a nuclear phosphoprotein that concentrates within Cajal bodies (CBs) and impacts small nuclear ribonucleoprotein (snRNP) biogenesis. Cisplatin and…”
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Differential effects of high fat diet and diet-induced obesity on skeletal acquisition in female C57BL/6J vs. FVB/NJ Mice by Devlin, M.J., Robbins, A., Cosman, M.N., Moursi, C.A., Cloutier, A.M., Louis, L., Van Vliet, M., Conlon, C., Bouxsein, M.L.

“…The effects of obesity on bone metabolism are complex, and may be mediated by consumption of a high fat diet and/or by obesity-induced metabolic dysregulation…”
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Memantine in the treatment of mild-to-moderate Alzheimer's disease by Cosman, Kelly M, Boyle, Lisa L, Porsteinsson, Anton P

“…Memantine is the first and only medication that has been approved by European, US and Canadian regulatory agencies for the treatment of moderate-to-severe…”
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Cauliflower Or Gene Encodes a DnaJ Cysteine-Rich Domain-Containing Protein That Mediates High Levels of β-Carotene Accumulation by Lu, Shan, Van Eck, Joyce, Zhou, Xiangjun, Lopez, Alex B, O'Halloran, Diana M, Cosman, Kelly M, Conlin, Brian J, Paolillo, Dominick J, Garvin, David F, Vrebalov, Julia, Kochian, Leon V, Küpper, Hendrik, Earle, Elizabeth D, Cao, Jun, Li, Li

“…Despite recent progress in our understanding of carotenogenesis in plants, the mechanisms that govern overall carotenoid accumulation remain largely unknown…”
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Pharmacokinetic Characterization in Xenografted Mice of a Series of First-Generation Mimics for HLA-DR Antibody, Lym-1, as Carrier Molecules to Image and Treat Lymphoma by DeNardo, Gerald L, Natarajan, Arutselvan, Hok, Saphon, Perkins, Julie, Cosman, Monique, DeNardo, Sally J, Lightstone, Felice C, Mirick, Gary R, Miers, Laird A, Balhorn, Rodney L

“…Despite their large size, antibodies (Abs) are suitable carriers to deliver systemic radiotherapy, often molecular image-based, for lymphoma and leukemia…”
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Solution Structure and Backbone Dynamics of the Human DNA Ligase IIIα BRCT Domain by Krishnan, V. V, Thornton, Kevin H, Thelen, Michael P, Cosman, Monique

“…BRCT (BRCA1 carboxyl terminus) domains are found in a number of DNA repair enzymes and cell cycle regulators and are believed to mediate important…”
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Dynamics of Cellular Retinoic Acid Binding Protein I on Multiple Time Scales with Implications for Ligand Binding by Krishnan, V. V, Sukumar, Muppalla, Gierasch, Lila M, Cosman, Monique

“…Cellular retinoic acid binding protein I (CRABPI) belongs to the family of intracellular lipid binding proteins (iLBPs), all of which bind a hydrophobic ligand…”
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Coilin interacts with Ku proteins and inhibits in vitro non-homologous DNA end joining by Velma, Venkatramreddy, Carrero, Zunamys I., Cosman, Angela M., Hebert, Michael D.

“…Coilin is a nuclear protein that plays a role in Cajal body formation. The function of nucleoplasmic coilin is unknown. Here we report that coilin interacts…”
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Solution Conformation of the Major Adduct Between the Carcinogen (+)-Anti- Benzo[a]Pyrene Diol Epoxide and DNA by Cosman, Monique, de los Santos, Carlos, Fiala, Radovan, Hingerty, Brian E., Singh, Suresh B., Ibanez, Victor, Margulis, Leonid A., Live, David, Geacintov, Nicholas E., Broyde, Suse, Patel, Dinshaw J.

“…We have synthesized, separated, and purified ≈ 10 mg of a deoxyundecanucleotide duplex containing a single centrally positioned covalent adduct between…”
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Distribution analysis of the photon correlation spectroscopy of discrete numbers of dye molecules conjugated to DNA by Fore, S., Laurence, T.A., Yeh, Y., Balhorn, R., Hollars, C.W., Cosman, M., Huser, T.

“…The formation of protein complexes with other proteins and nucleic acids is critical to biological function. Although it is relatively easy to identify the…”
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Coilin phosphorylation mediates interaction with SMN and SmB by Toyota, Cory G., Davis, Misty D., Cosman, Angela M., Hebert, Michael D.

“…Cajal bodies (CBs) are subnuclear domains that participate in spliceosomal small nuclear ribonucleoprotein (snRNP) biogenesis and play a part in the assembly…”
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Solution Conformation of the (−)-cis-anti-Benzo[a]pyrenyl-dG Adduct Opposite dC in a DNA Duplex:  Intercalation of the Covalently Attached BP Ring into the Helix with Base Displacement of the Modified Deoxyguanosine into the Major Groove by Cosman, Monique, Hingerty, Brian E, Luneva, Natalia, Amin, Shantu, Geacintov, Nicholas E, Broyde, Suse, Patel, Dinshaw J

“…This paper reports on the combined NMR−molecular mechanics computational studies of the solution structure of the (−)-cis-anti-[BP]dG adduct positioned…”
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Solution Conformation of the (-)-trans-anti-Benzo[c]phenanthrene-dA ([BPh]dA) Adduct opposite dT in a DNA Duplex: Intercalation of the Covalently Attached Benzo[c]phenanthrenyl Ring to the 3'-Side of the Adduct Site and Comparison with the (+)-trans-anti-[BPh]dA opposite dT Stereoisomer by Cosman, Monique, Laryea, Alfred, Fiala, Radovan, Hingerty, Brian E, Amin, Shantu, Geacintov, Nicholas E, Broyde, Suse, Patel, Dinshaw J

“…This paper reports on NMR-molecular mechanics structural studies of the (-)- trans-anti-benzo[c]phenanthrene-dA adduct positioned opposite dT in the sequence…”
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A Novel Flow Reactor for Studying Reactions on Liquid Surfaces Coated by Organic Monolayers:  Methods, Validation, and Initial Results by Knopf, D. A., Cosman, L. M., Mousavi, P., Mokamati, S., Bertram, A. K.

“…A new flow reactor has been developed that allows the study of heterogeneous kinetics on an aqueous surface coated by an organic monolayer. Computational fluid…”
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Structural alignments of (+)- and (-)-trans-anti-benzo[a]pyrene-dG adducts positioned at a DNA template-primer junction by Cosman, M, Hingerty, B E, Geacintov, N E, Broyde, S, Patel, D J

“…The structural features of a chemically modified DNA template strand may promote error-prone DNA synthesis during replication. The resulting higher incidence…”
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β-Carotene accumulation induced by the cauliflower Or gene is not due to an increased capacity of biosynthesis by Li, Li, Lu, Shan, Cosman, Kelly M., Earle, Elizabeth D., Garvin, David F., O’Neill, Jennifer

“…The cauliflower Or gene induces a high level of β-carotene accumulation in callus cultures, showing the orange phenotype found in the Or mutant plant. An…”
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Grumpy old men (and women): mere hassle or meaningful clinical evidence? by Porsteinsson, Anthony P, Cosman, Kelly M

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